PSS-232 F-18

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H21FN2O2
Molecular Weight	315.3725
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[18F]CCOCCCO\N=C1/CCCC(=C1)C#CC2=CC=CC=N2

InChI

InChIKey=PTUVTYFBBKVLPM-LGWHVOEDSA-N

InChI=1S/C18H21FN2O2/c19-10-14-22-12-4-13-23-21-18-7-3-5-16(15-18)8-9-17-6-1-2-11-20-17/h1-2,6,11,15H,3-5,7,10,12-14H2/b21-18+/i19-1

HIDE SMILES / InChI

Molecular Formula	C18H21FN2O2
Molecular Weight	315.3725
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 11:57:22 UTC 2023` Edited by `admin` on `Sat Dec 16 11:57:22 UTC 2023`
Record UNII	I8IX7L4V51
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PSS-232 F-18

Code

English

2-CYCLOHEXEN-1-ONE, 3-(2-(2-PYRIDINYL)ETHYNYL)-, O-(3-(2-(FLUORO-18F)ETHOXY)PROPYL)OXIME, (1E)-

Systematic Name

English

N-(3-(2-FLUORANYLETHOXY)PROPOXY)-3-(2-(2-PYRIDYL)ETHYNYL)CYCLOHEX-2-EN-1-IMINE

Systematic Name

English

18-FABP

Common Name

English

(E)-(18F)-PSS232

Code

English

(18F)PSS-232

Code

English

Code System Code Type Description

FDA UNII

I8IX7L4V51

Created by admin on Sat Dec 16 11:57:22 UTC 2023 , Edited by admin on Sat Dec 16 11:57:22 UTC 2023

PRIMARY

PUBCHEM

71816315

Created by admin on Sat Dec 16 11:57:22 UTC 2023 , Edited by admin on Sat Dec 16 11:57:22 UTC 2023

PRIMARY

CAS

1451015-40-9

Created by admin on Sat Dec 16 11:57:22 UTC 2023 , Edited by admin on Sat Dec 16 11:57:22 UTC 2023

PRIMARY

Related Record Type Details


					I8IX7L4V51

PSS-232 F-18

ACTIVE MOIETY

Comments:

Results: The distribution of (18F)-PSS232 closely matched that of the well-characterized tracer (11C)-ABP688. After 45 minutes, tracer uptake was highest in anterior cingulate, basal ganglia and temporal cortex. Uptake was lowest in white matter and cerebellum. Metabolism of the tracer was well-fitted by a single exponential model with approximately 70% intact tracer after 90 min. Tracer kinetics were best described by a two tissue-compartment model. The extraction fraction was initially estimated at 50%. Conclusions: Brain uptake of (18F)-PSS232 matched the expected distribution of mGluR5 and kinetic modeling indicated that distribution volumes can be reliably estimated. A bolus/infusion protocol will be investigated and dosimetry measured.