U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C17H18N2O6
Molecular Weight 346.3346
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NIFEDIPINE

SMILES

COC(=O)C1=C(C)NC(C)=C(C1C2=C(C=CC=C2)[N+]([O-])=O)C(=O)OC

InChI

InChIKey=HYIMSNHJOBLJNT-UHFFFAOYSA-N
InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3

HIDE SMILES / InChI
Molecular Formula C17H18N2O6
Molecular Weight 346.3346
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Sat Dec 16 17:58:49 UTC 2023
Edited
by admin
on Sat Dec 16 17:58:49 UTC 2023
Record UNII
I9ZF7L6G2L
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NIFEDIPINE
EP   HSDB   INN   MART.   MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF   WHO-DD   WHO-IP  
INCI   INN   USAN  
Official Name English
NIFEDIPINE [USP MONOGRAPH]
Common Name English
NIFEDIPINE [USP-RS]
Common Name English
NSC-757242
Code English
NIFEDIPINE [INCI]
Common Name English
AFEDITAB CR
Brand Name English
NIFEDIPINE SLOW RELEASE
Common Name English
ADALAT
Brand Name English
NIFEDIPINE [WHO-IP]
Common Name English
NIFEDIPINUM [WHO-IP LATIN]
Common Name English
PROCARDIA
Brand Name English
NIFEDIPINE [ORANGE BOOK]
Common Name English
NIFEDIPINE [USAN]
Common Name English
Nifedipine [WHO-DD]
Common Name English
BAY A 1040
Code English
NIFEDIPINE [VANDF]
Common Name English
NIFEDIPINE [EP MONOGRAPH]
Common Name English
NIFEDIPINE [USP IMPURITY]
Common Name English
Dimethyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate
Systematic Name English
BAY-A-1040
Code English
NIFEDIPINE [MART.]
Common Name English
CORACTEN
Brand Name English
nifedipine [INN]
Common Name English
NIFEDIPINE [MI]
Common Name English
NIFEDIPINE [HSDB]
Common Name English
3,5-PYRIDINEDICARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-, DIMETHYL ESTER
Common Name English
NIFEDIPINE [JAN]
Common Name English
Classification Tree Code System Code
WHO-VATC QC08GA01
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
FDA ORPHAN DRUG 57991
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
NDF-RT N0000000069
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
WHO-ATC C08GA01
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
WHO-VATC QC08CA55
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
LIVERTOX NBK548324
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
NCI_THESAURUS C333
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
NDF-RT N0000007556
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
WHO-ATC C08CA55
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
WHO-ATC C08CA05
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
WHO-VATC QC08CA05
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
WHO-ESSENTIAL MEDICINES LIST 22.2
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
NDF-RT N0000175421
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
Code System Code Type Description
WHO INTERNATIONAL PHARMACOPEIA
NIFEDIPINE
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
PRIMARY Description. A yellow, crystalline powder.Solubility. Nifedipine is practically insoluble in water; freely soluble in acetone R; sparingly soluble in dehydrated ethanol R.Category. Cardiovascular drug; calcium-channel blocking agent.Storage. Nifedipine should be kept in a tightly closed container, protected from light.Additional information. CAUTION: Nifedipine decomposes on exposure to daylight, artificial light of certain wavelengths, andultraviolet light.Requirements: Nifedipine contains not less than 98.0% and not more than 102.0% of C17H18N2O6, calculated with reference to the driedsubstance.Note: Throughout the monograph perform the tests and the assay in the dark or under a suitable fluorescent light, using lowactinicglassware.
DRUG BANK
DB01115
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
PRIMARY
ECHA (EC/EINECS)
244-598-3
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
PRIMARY
INN
3222
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
PRIMARY
EPA CompTox
DTXSID2025715
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
PRIMARY
MESH
D009543
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
PRIMARY
NCI_THESAURUS
C29290
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
PRIMARY
DAILYMED
I9ZF7L6G2L
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
PRIMARY
CHEBI
7565
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
PRIMARY
MERCK INDEX
m7883
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
PRIMARY Merck Index
FDA UNII
I9ZF7L6G2L
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
PRIMARY
EVMPD
SUB09253MIG
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
PRIMARY
HSDB
7775
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
PRIMARY
CAS
21829-25-4
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
PRIMARY
PUBCHEM
4485
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
PRIMARY
RXCUI
7417
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
PRIMARY RxNorm
IUPHAR
2514
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
PRIMARY
WIKIPEDIA
NIFEDIPINE
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
PRIMARY
ChEMBL
CHEMBL193
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
PRIMARY
NSC
757242
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
PRIMARY
DRUG CENTRAL
1922
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
PRIMARY
LACTMED
Nifedipine
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
PRIMARY
SMS_ID
100000090371
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
PRIMARY
RS_ITEM_NUM
1463508
Created by admin on Sat Dec 16 17:58:51 UTC 2023 , Edited by admin on Sat Dec 16 17:58:51 UTC 2023
PRIMARY
Related Record Type Details
CYTOCHROME P450 3A5
METABOLIC ENZYME -> SUBSTRATE
Voltage-dependent L-type calcium channel subunit alpha-1C (Rat)
TARGET -> INHIBITOR
BINDING
IC50
VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
TARGET -> INHIBITOR
Structure of DEHYDRONIFEDIPINE
DEGRADENT -> PARENT
Structure of NIFEDIPINE HYDROCHLORIDE
SALT/SOLVATE -> PARENT
Structure of DEHYDRONITROSONIFEDIPINE
DEGRADENT -> PARENT
LIGHT INDUCED DEGRADENT
CYTOCHROME P450 3A4
METABOLIC ENZYME -> SUBSTRATE
Related Record Type Details
Structure of DEHYDRONIFEDIPINE
METABOLITE -> PARENT
PLASMA
Structure of DESISOBUTYL NISOLDIPINE
METABOLITE -> PARENT
MAJOR
URINE
Structure of 1,4,5,7-TETRAHYDRO-2-METHYL-4-(2-NITROPHENYL)-5-OXO-FURO(3,4-B)PYRIDINE-3-CARBOXYLIC ACID, METHYL ESTER
METABOLITE -> PARENT
MINOR
URINE
Structure of DESMETHYL DEHYDRONIFEDIPINE
METABOLITE -> PARENT
PLASMA; URINE
Related Record Type Details
Structure of DEHYDRONIFEDIPINE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of DEHYDRONITROSONIFEDIPINE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of METHYL 3-AMINO-2-BUTENOATE, (2E)-
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of BUTANOIC ACID, 2-((2-NITROPHENYL)METHYLENE)-3-OXO-, METHYL ESTER, (2Z)-
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
Structure of NIFEDIPINE
ACTIVE MOIETY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966