QUINIDINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H24N2O2
Molecular Weight	324.4168
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of QUINIDINE

Structure Search

SMILES

[H][C@@]1(C[C@@H]2CC[N@]1C[C@@H]2C=C)[C@@H](O)C3=C4C=C(OC)C=CC4=NC=C3

InChI

InChIKey=LOUPRKONTZGTKE-LHHVKLHASA-N

InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19+,20-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C20H24N2O2
Molecular Weight	324.4168
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:15:55 UTC 2023` Edited by `admin` on `Fri Dec 15 15:15:55 UTC 2023`
Record UNII	ITX08688JL
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

QUINIDINE

Common Name

English

(+)-QUINIDINE

Common Name

English

(9S)-6'-METHOXYCINCHONAN-9-OL

Systematic Name

English

QUINIDINE [MART.]

Common Name

English

.BETA.-QUINIDINE

Common Name

English

CONQUININE

Common Name

English

QUININE SULFATE IMPURITY A [EP IMPURITY]

Common Name

English

CINCHONAN-9-OL, 6'-METHOXY-, (9S)-

Common Name

English

Quinidine [WHO-DD]

Common Name

English

QUININE HYDROCHLORIDE IMPURITY A [EP IMPURITY]

Common Name

English

(8R,9S)-QUINIDINE

Common Name

English

QUINIDINE [VANDF]

Common Name

English

(S)-((2S,4S,5R)-5-ETHENYL-1-AZABICYCLO(2.2.2)OCT-2-YL)(6-METHOXYQUINOLIN-4-YL)METHANOL

Systematic Name

English

QUININE BISULFATE IMPURITY A [WHO-IP]

Common Name

English

QUININE BISULFATE HEPTAHYDRATE IMPURITY A [WHO-IP]

Common Name

English

PITAYINE

Common Name

English

QUININE SULFATE IMPURITY A [WHO-IP]

Common Name

English

QUINIDINE [HSDB]

Common Name

English

QUINIDINE [MI]

Common Name

English

KINIDIN

Common Name

English

Classification Tree Code System Code

WHO-VATC

QC01BA01

Created by admin on Fri Dec 15 15:15:55 UTC 2023 , Edited by admin on Fri Dec 15 15:15:55 UTC 2023

WHO-ATC

C01BA01

Created by admin on Fri Dec 15 15:15:55 UTC 2023 , Edited by admin on Fri Dec 15 15:15:55 UTC 2023

WHO-ATC

C01BA71

Created by admin on Fri Dec 15 15:15:55 UTC 2023 , Edited by admin on Fri Dec 15 15:15:55 UTC 2023

NDF-RT

N0000175426

Created by admin on Fri Dec 15 15:15:55 UTC 2023 , Edited by admin on Fri Dec 15 15:15:55 UTC 2023

WHO-VATC

QC01BA51

Created by admin on Fri Dec 15 15:15:55 UTC 2023 , Edited by admin on Fri Dec 15 15:15:55 UTC 2023

NDF-RT

N0000182135

Created by admin on Fri Dec 15 15:15:55 UTC 2023 , Edited by admin on Fri Dec 15 15:15:55 UTC 2023

LIVERTOX

NBK548869

Created by admin on Fri Dec 15 15:15:55 UTC 2023 , Edited by admin on Fri Dec 15 15:15:55 UTC 2023

WHO-VATC

QC01BA71

Created by admin on Fri Dec 15 15:15:55 UTC 2023 , Edited by admin on Fri Dec 15 15:15:55 UTC 2023

WHO-ATC

C01BA51

Created by admin on Fri Dec 15 15:15:55 UTC 2023 , Edited by admin on Fri Dec 15 15:15:55 UTC 2023

Code System Code Type Description

DRUG BANK

DB00908

Created by admin on Fri Dec 15 15:15:55 UTC 2023 , Edited by admin on Fri Dec 15 15:15:55 UTC 2023

PRIMARY

RXCUI

9068

Created by admin on Fri Dec 15 15:15:55 UTC 2023 , Edited by admin on Fri Dec 15 15:15:55 UTC 2023

PRIMARY

RxNorm

LACTMED

Quinidine

Created by admin on Fri Dec 15 15:15:55 UTC 2023 , Edited by admin on Fri Dec 15 15:15:55 UTC 2023

PRIMARY

NDF-RT

N0000182137

Created by admin on Fri Dec 15 15:15:55 UTC 2023 , Edited by admin on Fri Dec 15 15:15:55 UTC 2023

PRIMARY

Cytochrome P450 2D6 Inhibitors [MoA]

EVMPD

SUB04166MIG

Created by admin on Fri Dec 15 15:15:55 UTC 2023 , Edited by admin on Fri Dec 15 15:15:55 UTC 2023

PRIMARY

MESH

D011802

Created by admin on Fri Dec 15 15:15:55 UTC 2023 , Edited by admin on Fri Dec 15 15:15:55 UTC 2023

PRIMARY

IUPHAR

2342

Created by admin on Fri Dec 15 15:15:55 UTC 2023 , Edited by admin on Fri Dec 15 15:15:55 UTC 2023

PRIMARY

PUBCHEM

441074

Created by admin on Fri Dec 15 15:15:55 UTC 2023 , Edited by admin on Fri Dec 15 15:15:55 UTC 2023

PRIMARY

DAILYMED

ITX08688JL

Created by admin on Fri Dec 15 15:15:55 UTC 2023 , Edited by admin on Fri Dec 15 15:15:55 UTC 2023

PRIMARY

WIKIPEDIA

QUINIDINE

Created by admin on Fri Dec 15 15:15:55 UTC 2023 , Edited by admin on Fri Dec 15 15:15:55 UTC 2023

PRIMARY

MERCK INDEX

m9446

Created by admin on Fri Dec 15 15:15:55 UTC 2023 , Edited by admin on Fri Dec 15 15:15:55 UTC 2023

PRIMARY

Merck Index

HSDB

225

Created by admin on Fri Dec 15 15:15:55 UTC 2023 , Edited by admin on Fri Dec 15 15:15:55 UTC 2023

PRIMARY

EPA CompTox

DTXSID4023549

Created by admin on Fri Dec 15 15:15:55 UTC 2023 , Edited by admin on Fri Dec 15 15:15:55 UTC 2023

PRIMARY

ChEMBL

CHEMBL1294

Created by admin on Fri Dec 15 15:15:55 UTC 2023 , Edited by admin on Fri Dec 15 15:15:55 UTC 2023

PRIMARY

ECHA (EC/EINECS)

200-279-0

Created by admin on Fri Dec 15 15:15:55 UTC 2023 , Edited by admin on Fri Dec 15 15:15:55 UTC 2023

PRIMARY

CHEBI

28593

Created by admin on Fri Dec 15 15:15:55 UTC 2023 , Edited by admin on Fri Dec 15 15:15:55 UTC 2023

PRIMARY

DRUG CENTRAL

2346

Created by admin on Fri Dec 15 15:15:55 UTC 2023 , Edited by admin on Fri Dec 15 15:15:55 UTC 2023

PRIMARY

NCI_THESAURUS

C793

Created by admin on Fri Dec 15 15:15:55 UTC 2023 , Edited by admin on Fri Dec 15 15:15:55 UTC 2023

PRIMARY

SMS_ID

100000092616

Created by admin on Fri Dec 15 15:15:55 UTC 2023 , Edited by admin on Fri Dec 15 15:15:55 UTC 2023

PRIMARY

CAS

56-54-2

Created by admin on Fri Dec 15 15:15:55 UTC 2023 , Edited by admin on Fri Dec 15 15:15:55 UTC 2023

PRIMARY

FDA UNII

ITX08688JL

Created by admin on Fri Dec 15 15:15:55 UTC 2023 , Edited by admin on Fri Dec 15 15:15:55 UTC 2023

PRIMARY

Related Record Type Details


					515ZW3T4Z5

OCTN-1

TRANSPORTER -> SUBSTRATE


					HZ5B96234K

QUINIDINE DIHYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:


					8E4LAA4357

CYTOCHROME P450 2D6

METABOLIC ENZYME -> INHIBITOR

Interaction Type:

POTENT


					482M00274D

OCT-2

TRANSPORTER -> INHIBITOR


					22ES734693

MULTIDRUG RESISTANCE PROTEIN 1

TRANSPORTER -> SUBSTRATE

Comments:

in vitro ER in the MDCK-MDR1 cell line from National Institutes of Health

Qualification:

EFFLUX RATIO

Amount:


					R6875N380F

QUINIDINE GLUCONATE

SALT/SOLVATE -> PARENT

Amount:


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE


					2XX4SF4LD9

CYTOCHROME P450 2D15 (CANINE)

METABOLIC ENZYME -> INHIBITOR

Amount:


					ONY583280Z

OCT-1

TRANSPORTER -> SUBSTRATE


					B46KUN2O9L

MATE-2

TRANSPORTER -> INHIBITOR


					805SU96HKF

CYTOCHROME P450 3A5

METABOLIC ENZYME -> SUBSTRATE


					6NP3XSMIP3

MULTIDRUG AND TOXIN EXTRUSION PROTEIN 1

TRANSPORTER -> INHIBITOR


					3M13XS26I8

OCTN-2

TRANSPORTER -> SUBSTRATE


					ONY583280Z

OCT-1

TRANSPORTER -> INHIBITOR


					J13S2394HE

QUINIDINE SULFATE

SALT/SOLVATE -> PARENT

Amount:


					22ES734693

MULTIDRUG RESISTANCE PROTEIN 1

TRANSPORTER -> INHIBITOR


					W59Y55X20H

QUINIDINE LACTATE

SALT/SOLVATE -> PARENT

Amount:


					S4P5V5597B

QUINIDINE HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:


					90J73DI333

QUINIDINE HEMIPENTAHYDRATE

SOLVATE->ANHYDROUS

Amount:


					515ZW3T4Z5

OCTN-1

TRANSPORTER -> INHIBITOR


					4007E25Z4Z

OCT-3

TRANSPORTER -> INHIBITOR


					6K043Q65TR

QUINIDINE BISULFATE

SALT/SOLVATE -> PARENT

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Amount:

Related Record Type Details


					T0RV6T22HZ

QUINIDINE N-OXIDE

METABOLITE -> PARENT

Interaction Type:

MAJOR

Amount:


					00G939C83O

3-HYDROXYQUINIDINE

METABOLITE LESS ACTIVE -> PARENT

Comments:

Metabolite to parent drug ratio in non-uraemic human plasma.

Interaction Type:

METABOLITE TO PARENT DRUG RATIO

Qualification:

PLASMA; URINE

Amount:


					00G939C83O

3-HYDROXYQUINIDINE

METABOLITE LESS ACTIVE -> PARENT

Comments:

quinidine is metabolized by CYP3A4 (In vitro)

Amount:


					J92F7F8BAO

LNC-834 FREE BASE

METABOLITE -> PARENT

Amount:


					00G939C83O

3-HYDROXYQUINIDINE

METABOLITE LESS ACTIVE -> PARENT

Interaction Type:

MAJOR

Qualification:

FECAL; PLASMA; URINE

Amount:

Related Record Type Details


					711S8Y0T33

QUININE HYDROCHLORIDE

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					M201HC068W

QUININE BISULFATE

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

INTERNATIONAL PHARMACOPEIA

Amount:


					GNS01V2R3N

QUININE BISULFATE HEPTAHYDRATE

PARENT -> IMPURITY

Comments:

Not Specified

Amount:


					KF7Z0E0Q2B

QUININE SULFATE

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					J13S2394HE

QUINIDINE SULFATE

PARENT -> IMPURITY

Comments:

Not Specified

Amount:


					KF7Z0E0Q2B

QUININE SULFATE

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

INTERNATIONAL PHARMACOPEIA

Amount:

Related Record Type Details


					ITX08688JL

QUINIDINE

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC				Heart Failure PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC				Elimination PHARMACOKINETIC Elimination PHARMACOKINETIC