FONDAPARINUX

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C31H53N3O49S8
Molecular Weight	1508.263
Optical Activity	UNSPECIFIED
Defined Stereocenters	25 / 25
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of FONDAPARINUX

Structure Search

SMILES

[H][C@@]4(O[C@@H]1[C@@H](COS(O)(=O)=O)O[C@]([H])(O[C@H]2[C@H](O)[C@@H](OS(O)(=O)=O)[C@]([H])(O[C@H]3[C@H](O)[C@@H](NS(O)(=O)=O)[C@@H](OC)O[C@@H]3COS(O)(=O)=O)O[C@H]2C(O)=O)[C@H](NS(O)(=O)=O)[C@H]1OS(O)(=O)=O)O[C@@H]([C@@H](O[C@@]5([H])O[C@H](COS(O)(=O)=O)[C@@H](O)[C@H](O)[C@H]5NS(O)(=O)=O)[C@H](O)[C@H]4O)C(O)=O

InChI

InChIKey=KANJSNBRCNMZMV-ABRZTLGGSA-N

InChI=1S/C31H53N3O49S8/c1-69-27-9(33-85(48,49)50)13(37)17(6(74-27)3-71-88(57,58)59)76-31-22(83-91(66,67)68)16(40)21(24(81-31)26(43)44)79-29-10(34-86(51,52)53)19(82-90(63,64)65)18(7(75-29)4-72-89(60,61)62)77-30-15(39)14(38)20(23(80-30)25(41)42)78-28-8(32-84(45,46)47)12(36)11(35)5(73-28)2-70-87(54,55)56/h5-24,27-40H,2-4H2,1H3,(H,41,42)(H,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)(H,54,55,56)(H,57,58,59)(H,60,61,62)(H,63,64,65)(H,66,67,68)/t5-,6-,7-,8-,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-,19-,20+,21+,22-,23+,24-,27+,28-,29-,30-,31-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C31H53N3O49S8
Molecular Weight	1508.263
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	25 / 25
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:44:28 UTC 2023` Edited by `admin` on `Fri Dec 15 15:44:28 UTC 2023`
Record UNII	J177FOW5JL
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

FONDAPARINUX

Common Name

English

FONDAPARINUX [VANDF]

Common Name

English

FONDAPARINUX [HSDB]

Common Name

English

Fondaparinux [WHO-DD]

Common Name

English

Classification Tree Code System Code

LIVERTOX

NBK548551

Created by admin on Fri Dec 15 15:44:28 UTC 2023 , Edited by admin on Fri Dec 15 15:44:28 UTC 2023

WHO-ATC

B01AX05

Created by admin on Fri Dec 15 15:44:28 UTC 2023 , Edited by admin on Fri Dec 15 15:44:28 UTC 2023

LOINC

74217-1

Created by admin on Fri Dec 15 15:44:28 UTC 2023 , Edited by admin on Fri Dec 15 15:44:28 UTC 2023

NCI_THESAURUS

C263

Created by admin on Fri Dec 15 15:44:28 UTC 2023 , Edited by admin on Fri Dec 15 15:44:28 UTC 2023

NDF-RT

N0000175635

Created by admin on Fri Dec 15 15:44:28 UTC 2023 , Edited by admin on Fri Dec 15 15:44:28 UTC 2023

NDF-RT

N0000175637

Created by admin on Fri Dec 15 15:44:28 UTC 2023 , Edited by admin on Fri Dec 15 15:44:28 UTC 2023

WHO-VATC

QB01AX05

Created by admin on Fri Dec 15 15:44:28 UTC 2023 , Edited by admin on Fri Dec 15 15:44:28 UTC 2023

Code System Code Type Description

NCI_THESAURUS

C73142

Created by admin on Fri Dec 15 15:44:28 UTC 2023 , Edited by admin on Fri Dec 15 15:44:28 UTC 2023

PRIMARY

CAS

104993-28-4

Created by admin on Fri Dec 15 15:44:28 UTC 2023 , Edited by admin on Fri Dec 15 15:44:28 UTC 2023

PRIMARY

RXCUI

321208

Created by admin on Fri Dec 15 15:44:28 UTC 2023 , Edited by admin on Fri Dec 15 15:44:28 UTC 2023

PRIMARY

RxNorm

DRUG BANK

DB00569

Created by admin on Fri Dec 15 15:44:28 UTC 2023 , Edited by admin on Fri Dec 15 15:44:28 UTC 2023

PRIMARY

DAILYMED

J177FOW5JL

Created by admin on Fri Dec 15 15:44:28 UTC 2023 , Edited by admin on Fri Dec 15 15:44:28 UTC 2023

PRIMARY

PUBCHEM

5282448

Created by admin on Fri Dec 15 15:44:28 UTC 2023 , Edited by admin on Fri Dec 15 15:44:28 UTC 2023

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EPA CompTox

DTXSID10146903

Created by admin on Fri Dec 15 15:44:28 UTC 2023 , Edited by admin on Fri Dec 15 15:44:28 UTC 2023

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DRUG CENTRAL

1236

Created by admin on Fri Dec 15 15:44:28 UTC 2023 , Edited by admin on Fri Dec 15 15:44:28 UTC 2023

PRIMARY

EVMPD

SUB25907

Created by admin on Fri Dec 15 15:44:28 UTC 2023 , Edited by admin on Fri Dec 15 15:44:28 UTC 2023

PRIMARY

SMS_ID

100000090128

Created by admin on Fri Dec 15 15:44:28 UTC 2023 , Edited by admin on Fri Dec 15 15:44:28 UTC 2023

PRIMARY

HSDB

7845

Created by admin on Fri Dec 15 15:44:28 UTC 2023 , Edited by admin on Fri Dec 15 15:44:28 UTC 2023

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LACTMED

Fondaparinux

Created by admin on Fri Dec 15 15:44:28 UTC 2023 , Edited by admin on Fri Dec 15 15:44:28 UTC 2023

PRIMARY

FDA UNII

J177FOW5JL

Created by admin on Fri Dec 15 15:44:28 UTC 2023 , Edited by admin on Fri Dec 15 15:44:28 UTC 2023

PRIMARY

WIKIPEDIA

FONDAPARINUX

Created by admin on Fri Dec 15 15:44:28 UTC 2023 , Edited by admin on Fri Dec 15 15:44:28 UTC 2023

PRIMARY

IUPHAR

6819

Created by admin on Fri Dec 15 15:44:28 UTC 2023 , Edited by admin on Fri Dec 15 15:44:28 UTC 2023

PRIMARY

MESH

C438268

Created by admin on Fri Dec 15 15:44:28 UTC 2023 , Edited by admin on Fri Dec 15 15:44:28 UTC 2023

PRIMARY

Related Record Type Details


					J177FOW5JL

EXCRETED UNCHANGED

Comments:

In individuals with normal kidney function fondaparinux is eliminated in urine mainly as unchanged drug. In healthy individuals up to 75 years of age, up to 77% of a single subcutaneous or intravenous dose fondaparinux is eliminated in urine as unchanged drug in 72 hours.

Amount:


					HYF6HN9XGQ

FACTOR XA

TARGET -> INHIBITOR

Amount:


					T0LTO7L82X

ANTITHROMBIN III HUMAN

LIGAND->BINDER

Interaction Type:

BINDING

Amount:


					X0Q6N9USOZ

FONDAPARINUX SODIUM

SALT/SOLVATE -> PARENT

Amount:

Related Record Type Details


					J177FOW5JL

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Tmax	PHARMACOKINETIC				SINGLE DOSE IN YOUNG MALE SUBJECTS SUBCUTANEOUS ADMINISTRATION

Volume of Distribution	PHARMACOKINETIC				INTRAVENOUS ADMINISTRATION SUBCUTANEOUS ADMINISTRATION

Biological Half-life	PHARMACOKINETIC				SUBCUTANEOUS ADMINISTRATION