LECILIMOGENE AUTOTEMCEL

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Sat Dec 16 19:10:05 UTC 2023` Edited by `admin` on `Sat Dec 16 19:10:05 UTC 2023`
Source Materials Class	ORGANISM
Source Materials Type	ALLOGENIC HUMAN
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	BLOOD
Fraction Name	CD34+ cells isolated from mobilized peripheral blood of patients who received a prior hematopoietic stem cell transplanted X-linked severe combined immunodeficiency (X-SCID) patients
Record UNII	J6D55C56ED
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LECILIMOGENE AUTOTEMCEL

Official Name

English

AUTOLOGOUS CD34+ CELLS OBTAINED BY APHERESIS FROM MOBILISED PERIPHERAL BLOOD OF PATIENTS WHO RECEIVED A PRIOR HEMATOPOIETIC STEM CELL TRANSPLANT, TRANSDUCED EX-VIVO WITH A SELF-INACTIVATING LENTIVIRAL VECTOR, ENCODING CODON-OPTIMIZED HUMAN INTERLEUKIN-2

Common Name

English

lecilimogene autotemcel [INN]

Common Name

English

Code System Code Type Description

FDA UNII

J6D55C56ED

Created by admin on Sat Dec 16 19:10:06 UTC 2023 , Edited by admin on Sat Dec 16 19:10:06 UTC 2023

PRIMARY

NCI_THESAURUS

C188589

Created by admin on Sat Dec 16 19:10:06 UTC 2023 , Edited by admin on Sat Dec 16 19:10:06 UTC 2023

PRIMARY

INN

12063

Created by admin on Sat Dec 16 19:10:06 UTC 2023 , Edited by admin on Sat Dec 16 19:10:06 UTC 2023

PRIMARY

Related Record Type Details


					OX7CIS4H0Z

CYTOKINE RECEPTOR COMMON SUBUNIT GAMMA

EXPRESSED PROTEIN->VECTOR

Amount:

Related Record Type Details


					J6D55C56ED

LECILIMOGENE AUTOTEMCEL

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Fragment Name	Fragment ID
CULTURE		THROMBOPOIETIN	5651J3R2JF
CULTURE		ALBUMIN HUMAN	ZIF514RVZR
CULTURE		FLT-3 LIGAND PROTEIN (MAMMALIAN GLYCOSYLATION)	6S1KJ9KP8S
LENTIVIRAL TRANSFECTION	TRANSFECTION	FIROLIMOGENE AUTOTEMCEL VECTOR	PZ6C5A9U4S
CULTURE		HUMAN SOLUBLE KIT LIGAND	ED35EH7CP2

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
INSERTED GENE EXPRESSION VECTOR					FIROLIMOGENE AUTOTEMCEL TRANSGENE INSERT	73GRS55F42
VECTOR EXPRESSED PROTEIN					CYTOKINE RECEPTOR COMMON SUBUNIT GAMMA	OX7CIS4H0Z