EFINACONAZOLE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C18H22F2N4O
Molecular Weight	348.3903
Optical Activity	( - )
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of EFINACONAZOLE

Structure Search

SMILES

C[C@@H](N1CCC(=C)CC1)[C@](O)(CN2C=NC=N2)C3=CC=C(F)C=C3F

InChI

InChIKey=NFEZZTICAUWDHU-RDTXWAMCSA-N

InChI=1S/C18H22F2N4O/c1-13-5-7-23(8-6-13)14(2)18(25,10-24-12-21-11-22-24)16-4-3-15(19)9-17(16)20/h3-4,9,11-12,14,25H,1,5-8,10H2,2H3/t14-,18-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C18H22F2N4O
Molecular Weight	348.3903
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:03:57 UTC 2023` Edited by `admin` on `Sat Dec 16 17:03:57 UTC 2023`
Record UNII	J82SB7FXWB
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

EFINACONAZOLE

Official Name

English

Efinaconazole [WHO-DD]

Common Name

English

IDP-108

Code

English

EFINACONAZOLE [ORANGE BOOK]

Common Name

English

CLENAFIN

Brand Name

English

EFINACONAZOLE [JAN]

Common Name

English

1-PIPERIDINEETHANOL, .ALPHA.-(2,4-DIFLUOROPHENYL)-.BETA.-METHYL-4-METHYLENE-.ALPHA.-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-,(.ALPHA.R,.BETA.R)-

Common Name

English

JUBLIA

Brand Name

English

(2R,3R)-2-(2,4-DIFLUOROFENIL)-3-(4-METILENOPIPERIDIN-1-IL)-1-(1H-1,2,4-TRIAZIN-1-IL)BUTAN-2-OL

Common Name

English

EFINACONAZOLE [MI]

Common Name

English

KP-103

Code

English

1-PIPERIDINEETHANOL, .ALPHA.-(2,4-DIFLUOROPHENYL)-.BETA.-METHYL-4-METHYLENE-.ALPHA.-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-, (R-(R*,R*))-

Common Name

English

efinaconazole [INN]

Common Name

English

EFINACONAZOLE [USAN]

Common Name

English

(2R,3R)-2-(2,4-Difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Systematic Name

English

EFINACONAZOLE [VANDF]

Common Name

English

Classification Tree Code System Code

NDF-RT

N0000175487

Created by admin on Sat Dec 16 17:03:58 UTC 2023 , Edited by admin on Sat Dec 16 17:03:58 UTC 2023

WHO-ATC

D01AC19

Created by admin on Sat Dec 16 17:03:58 UTC 2023 , Edited by admin on Sat Dec 16 17:03:58 UTC 2023

NCI_THESAURUS

C514

Created by admin on Sat Dec 16 17:03:58 UTC 2023 , Edited by admin on Sat Dec 16 17:03:58 UTC 2023

Code System Code Type Description

DAILYMED

J82SB7FXWB

Created by admin on Sat Dec 16 17:03:58 UTC 2023 , Edited by admin on Sat Dec 16 17:03:58 UTC 2023

PRIMARY

FDA UNII

J82SB7FXWB

Created by admin on Sat Dec 16 17:03:58 UTC 2023 , Edited by admin on Sat Dec 16 17:03:58 UTC 2023

PRIMARY

EPA CompTox

DTXSID40167787

Created by admin on Sat Dec 16 17:03:58 UTC 2023 , Edited by admin on Sat Dec 16 17:03:58 UTC 2023

PRIMARY

PUBCHEM

489181

Created by admin on Sat Dec 16 17:03:58 UTC 2023 , Edited by admin on Sat Dec 16 17:03:58 UTC 2023

PRIMARY

USAN

YY-95

Created by admin on Sat Dec 16 17:03:58 UTC 2023 , Edited by admin on Sat Dec 16 17:03:58 UTC 2023

PRIMARY

WIKIPEDIA

Efinaconazole

Created by admin on Sat Dec 16 17:03:58 UTC 2023 , Edited by admin on Sat Dec 16 17:03:58 UTC 2023

PRIMARY

SMS_ID

100000163626

Created by admin on Sat Dec 16 17:03:58 UTC 2023 , Edited by admin on Sat Dec 16 17:03:58 UTC 2023

PRIMARY

DRUG BANK

DB09040

Created by admin on Sat Dec 16 17:03:58 UTC 2023 , Edited by admin on Sat Dec 16 17:03:58 UTC 2023

PRIMARY

JAPANESE REVIEW

CLENAFIN

Created by admin on Sat Dec 16 17:03:58 UTC 2023 , Edited by admin on Sat Dec 16 17:03:58 UTC 2023

PRIMARY

APPROVED JULY 2014

INN

9349

Created by admin on Sat Dec 16 17:03:58 UTC 2023 , Edited by admin on Sat Dec 16 17:03:58 UTC 2023

PRIMARY

ChEMBL

CHEMBL2103877

Created by admin on Sat Dec 16 17:03:58 UTC 2023 , Edited by admin on Sat Dec 16 17:03:58 UTC 2023

PRIMARY

NCI_THESAURUS

C97998

Created by admin on Sat Dec 16 17:03:58 UTC 2023 , Edited by admin on Sat Dec 16 17:03:58 UTC 2023

PRIMARY

EVMPD

SUB177957

Created by admin on Sat Dec 16 17:03:58 UTC 2023 , Edited by admin on Sat Dec 16 17:03:58 UTC 2023

PRIMARY

MERCK INDEX

m11729

Created by admin on Sat Dec 16 17:03:58 UTC 2023 , Edited by admin on Sat Dec 16 17:03:58 UTC 2023

PRIMARY

HSDB

8341

Created by admin on Sat Dec 16 17:03:58 UTC 2023 , Edited by admin on Sat Dec 16 17:03:58 UTC 2023

PRIMARY

DRUG CENTRAL

4874

Created by admin on Sat Dec 16 17:03:58 UTC 2023 , Edited by admin on Sat Dec 16 17:03:58 UTC 2023

PRIMARY

CHEBI

82718

Created by admin on Sat Dec 16 17:03:58 UTC 2023 , Edited by admin on Sat Dec 16 17:03:58 UTC 2023

PRIMARY

LACTMED

Efinaconazole

Created by admin on Sat Dec 16 17:03:58 UTC 2023 , Edited by admin on Sat Dec 16 17:03:58 UTC 2023

PRIMARY

RXCUI

1539753

Created by admin on Sat Dec 16 17:03:58 UTC 2023 , Edited by admin on Sat Dec 16 17:03:58 UTC 2023

PRIMARY

RxNorm

CAS

164650-44-6

Created by admin on Sat Dec 16 17:03:58 UTC 2023 , Edited by admin on Sat Dec 16 17:03:58 UTC 2023

PRIMARY

Related Record Type Details


					EXBR80OUAD

LANOSTEROL 14-ALPHA DEMETHYLASE

TARGET -> INHIBITOR

Related Record Type Details


					KX22UA4JX9

.ALPHA.-(2,4-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-ETHANOL

METABOLITE INACTIVE -> PARENT

Comments:

In-vivo, H3 was the major metabolite in human plasma and it is inactive. This was the only metabolite that was higher or equal to efinaconazole levels

Interaction Type:

MAJOR

Qualification:

PLASMA

Amount:


					10MS0Y1RDI

1H-1,2,4-TRIAZOLE

METABOLITE -> PARENT

Amount:


					Z52R5AA49Z

1-((1R,2R)-2-(2,4-DIFLUOROPHENYL)-2-HYDROXY-1-METHYL-3-(1,2,4-TRIAZOL-1-YL)PROPYL)-4-(HYDROXYMETHYL)PIPERIDIN-4-OL

METABOLITE -> PARENT

Interaction Type:

MAJOR

Amount:


					1F8K4N408B

2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol, (2R,3R)-

METABOLITE -> PARENT

Amount:


					9DDX8HSZ9L

(2R,3R)-2-(2,4-DIFLUOROPHENYL)-3-(4-(HYDROXYMETHYL)-1-PIPERIDYL)-1-(1,2,4-TRIAZOL-1-YL)BUTAN-2-OL

METABOLITE -> PARENT

Amount:

Related Record Type Details


					J82SB7FXWB

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC				DAILY APPLICATIONS