ROLIPRAM

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C16H21NO3
Molecular Weight	275.3428
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ROLIPRAM

Structure Search

SMILES

COC1=CC=C(C=C1OC2CCCC2)C3CNC(=O)C3

InChI

InChIKey=HJORMJIFDVBMOB-UHFFFAOYSA-N

InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)

HIDE SMILES / InChI

Molecular Formula	C16H21NO3
Molecular Weight	275.3428
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:32:19 UTC 2023` Edited by `admin` on `Fri Dec 15 15:32:19 UTC 2023`
Record UNII	K676NL63N7
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ROLIPRAM

Official Name

English

ROLIPRAM [MI]

Common Name

English

(±)-ROLIPRAM

Common Name

English

SB-95952

Code

English

Rolipram [WHO-DD]

Common Name

English

ZK-62771

Code

English

(R,S)-ROLIPRAM

Common Name

English

4-(3-CYCLOPENTYLOXY-4-METHOXYPHENYL)PYRROLIDONE

Systematic Name

English

ZK 62 711

Code

English

ROLIPRAM [JAN]

Common Name

English

ROLIPRAM [MART.]

Common Name

English

ZK-62711

Code

English

ROLIPRAM [USAN]

Common Name

English

NSC-760125

Code

English

rolipram [INN]

Common Name

English

4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257

Created by admin on Fri Dec 15 15:32:19 UTC 2023 , Edited by admin on Fri Dec 15 15:32:19 UTC 2023

NCI_THESAURUS

C744

Created by admin on Fri Dec 15 15:32:19 UTC 2023 , Edited by admin on Fri Dec 15 15:32:19 UTC 2023

Code System Code Type Description

EVMPD

SUB10367MIG

Created by admin on Fri Dec 15 15:32:19 UTC 2023 , Edited by admin on Fri Dec 15 15:32:19 UTC 2023

PRIMARY

INN

4362

Created by admin on Fri Dec 15 15:32:19 UTC 2023 , Edited by admin on Fri Dec 15 15:32:19 UTC 2023

PRIMARY

FDA UNII

K676NL63N7

Created by admin on Fri Dec 15 15:32:19 UTC 2023 , Edited by admin on Fri Dec 15 15:32:19 UTC 2023

PRIMARY

ChEMBL

CHEMBL63

Created by admin on Fri Dec 15 15:32:19 UTC 2023 , Edited by admin on Fri Dec 15 15:32:19 UTC 2023

PRIMARY

ECHA (EC/EINECS)

262-771-1

Created by admin on Fri Dec 15 15:32:19 UTC 2023 , Edited by admin on Fri Dec 15 15:32:19 UTC 2023

PRIMARY

EPA CompTox

DTXSID3044124

Created by admin on Fri Dec 15 15:32:19 UTC 2023 , Edited by admin on Fri Dec 15 15:32:19 UTC 2023

PRIMARY

MESH

D020889

Created by admin on Fri Dec 15 15:32:19 UTC 2023 , Edited by admin on Fri Dec 15 15:32:19 UTC 2023

PRIMARY

MERCK INDEX

m9650

Created by admin on Fri Dec 15 15:32:19 UTC 2023 , Edited by admin on Fri Dec 15 15:32:19 UTC 2023

PRIMARY

Merck Index

PUBCHEM

5092

Created by admin on Fri Dec 15 15:32:19 UTC 2023 , Edited by admin on Fri Dec 15 15:32:19 UTC 2023

PRIMARY

NSC

760125

Created by admin on Fri Dec 15 15:32:19 UTC 2023 , Edited by admin on Fri Dec 15 15:32:19 UTC 2023

PRIMARY

CAS

85416-74-6

Created by admin on Fri Dec 15 15:32:19 UTC 2023 , Edited by admin on Fri Dec 15 15:32:19 UTC 2023

SUPERSEDED

DRUG BANK

DB01954

Created by admin on Fri Dec 15 15:32:19 UTC 2023 , Edited by admin on Fri Dec 15 15:32:19 UTC 2023

PRIMARY

CAS

61413-54-5

Created by admin on Fri Dec 15 15:32:19 UTC 2023 , Edited by admin on Fri Dec 15 15:32:19 UTC 2023

PRIMARY

CHEBI

104872

Created by admin on Fri Dec 15 15:32:19 UTC 2023 , Edited by admin on Fri Dec 15 15:32:19 UTC 2023

PRIMARY

SMS_ID

100000084332

Created by admin on Fri Dec 15 15:32:19 UTC 2023 , Edited by admin on Fri Dec 15 15:32:19 UTC 2023

PRIMARY

WIKIPEDIA

ROLIPRAM

Created by admin on Fri Dec 15 15:32:19 UTC 2023 , Edited by admin on Fri Dec 15 15:32:19 UTC 2023

PRIMARY

CHEBI

40133

Created by admin on Fri Dec 15 15:32:19 UTC 2023 , Edited by admin on Fri Dec 15 15:32:19 UTC 2023

PRIMARY

NCI_THESAURUS

C72842

Created by admin on Fri Dec 15 15:32:19 UTC 2023 , Edited by admin on Fri Dec 15 15:32:19 UTC 2023

PRIMARY

Related Record Type Details


					FMS08T2916

CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D

TARGET -> INHIBITOR

Qualification:

IC50

Amount:


					H6G4VMQ24K

ENANTIOMER -> RACEMATE

Amount:


					651CFC5G66

CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4A

TARGET -> INHIBITOR

Comments:

Rolipram has good brain penetration, or an ability to pass the blood−brain barrier.

Qualification:

IC50

Amount:


					DPX51KUP08

ENANTIOMER -> RACEMATE

Amount:

Related Record Type Details


					K676NL63N7

ROLIPRAM

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
BRAIN/PLASMA RATIO	PHARMACOKINETIC				Species BIOLOGICAL Route of adminstration PHARMACOKINETIC