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Details

Stereochemistry ABSOLUTE
Molecular Formula C43H65N5O10
Molecular Weight 812.0037
Optical Activity UNSPECIFIED
Defined Stereocenters 13 / 13
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TELITHROMYCIN

SMILES

[H][C@@]2(O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)N(CCCCN4C=NC(=C4)C5=CC=CN=C5)[C@@H]3[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC

InChI

InChIKey=LJVAJPDWBABPEJ-PNUFFHFMSA-N
InChI=1S/C43H65N5O10/c1-12-33-43(8)37(48(41(53)58-43)19-14-13-18-47-23-31(45-24-47)30-16-15-17-44-22-30)27(4)34(49)25(2)21-42(7,54-11)38(28(5)35(50)29(6)39(52)56-33)57-40-36(51)32(46(9)10)20-26(3)55-40/h15-17,22-29,32-33,36-38,40,51H,12-14,18-21H2,1-11H3/t25-,26-,27+,28+,29-,32+,33-,36-,37-,38-,40+,42-,43-/m1/s1

HIDE SMILES / InChI
Molecular Formula C43H65N5O10
Molecular Weight 812.0037
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 13 / 13
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Sat Dec 16 17:34:26 UTC 2023
Edited
by admin
on Sat Dec 16 17:34:26 UTC 2023
Record UNII
KI8H7H19WL
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TELITHROMYCIN
EMA EPAR   HSDB   INN   JAN   MART.   MI   ORANGE BOOK   USAN   VANDF   WHO-DD  
USAN   INN  
Official Name English
TELITHROMYCIN [MART.]
Common Name English
TELITHROMYCIN [MI]
Common Name English
TELITHROMYCIN [USAN]
Common Name English
LEVVIAX
Brand Name English
Telithromycin [WHO-DD]
Common Name English
KETEK
Brand Name English
TELITHROMYCIN [EMA EPAR]
Common Name English
TELITHROMYCIN [VANDF]
Common Name English
ERYTHROMYCIN,3-DE((2,6-DIDEOXY-3-C-METHYL-3-O-METHYL-.ALPHA.-L-RIBO-HEXOPYRANOSYL)OXY)-11,12-DIDEOXY-6-O-METHYL-3-OXO-12,11-(OXYCARBONYL((4-(4-(3-PYRIDINYL)-1H-IMIDAZOL-1-YL)BUTYL)IMINO)-
Common Name English
NSC-758940
Code English
HMR-3647
Code English
telithromycin [INN]
Common Name English
TELITHROMYCIN [JAN]
Common Name English
TELITHROMYCIN [ORANGE BOOK]
Common Name English
HMR3647
Code English
TELITHROMYCIN [HSDB]
Common Name English
Classification Tree Code System Code
WHO-ATC J01FA15
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
EMA ASSESSMENT REPORTS LEVVIAX (WITHDRAWN: TONSILLITIS)
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
EMA ASSESSMENT REPORTS LEVVIAX (WITHDRAWN: PHARYNGITIS)
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
NDF-RT N0000011414
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
WHO-VATC QJ01FA15
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
NDF-RT N0000011414
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
NCI_THESAURUS C261
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
EMA ASSESSMENT REPORTS KETEK (AUTHORIZED: TONSILLITIS)
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
EMA ASSESSMENT REPORTS KETEK (AUTHORIZED: PHARYNGITIS)
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
NDF-RT N0000175492
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
LIVERTOX NBK548597
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
NDF-RT N0000011414
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
Code System Code Type Description
LACTMED
Telithromycin
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
PRIMARY
PUBCHEM
3002190
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
PRIMARY
MERCK INDEX
m10531
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
PRIMARY Merck Index
INN
7803
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
PRIMARY
MESH
C106791
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
PRIMARY
CAS
191114-48-4
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
PRIMARY
WIKIPEDIA
TELITHROMYCIN
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
PRIMARY
EPA CompTox
DTXSID3046455
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
PRIMARY
CAS
173838-31-8
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
SUPERSEDED
USAN
QQ-66
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
PRIMARY
EVMPD
SUB12606MIG
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
PRIMARY
SMS_ID
100000089311
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
PRIMARY
HSDB
7359
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
PRIMARY
NCI_THESAURUS
C61963
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
PRIMARY
RXCUI
274786
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
PRIMARY RxNorm
FDA UNII
KI8H7H19WL
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
PRIMARY
ChEMBL
CHEMBL1136
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
PRIMARY
NSC
758940
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
PRIMARY
DRUG CENTRAL
2581
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
PRIMARY
DAILYMED
KI8H7H19WL
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
PRIMARY
DRUG BANK
DB00976
Created by admin on Sat Dec 16 17:34:29 UTC 2023 , Edited by admin on Sat Dec 16 17:34:29 UTC 2023
PRIMARY
Related Record Type Details
LEGIONELLA PNEUMOPHILA
TARGET ORGANISM->INHIBITOR
HAEMOPHILUS INFLUENZAE
TARGET ORGANISM->INHIBITOR
Structure of TELITHROMYCIN
EXCRETED UNCHANGED
URINE
MYCOPLASMA PNEUMONIAE
TARGET ORGANISM->INHIBITOR
CYTOCHROME P450 3A4
METABOLIC ENZYME -> INDUCER
POTENT
STREPTOCOCCUS AGALACTIAE
TARGET ORGANISM->INHIBITOR
CYTOCHROME P450 2D6
METABOLIC ENZYME -> INHIBITOR
Ki
Structure of TELITHROMYCIN
EXCRETED UNCHANGED
FECAL
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
Total in vitro protein binding is approximately 60% to 70% and is primarily due to human serum albumin. Protein binding is not modified in elderly subjects and in patients with hepatic impairment.
BINDING
CYTOCHROME P450 3A4
METABOLIC ENZYME -> SUBSTRATE
MAJOR
MORAXELLA CATARRHALIS
TARGET ORGANISM->INHIBITOR
STREPTOCOCCUS PYOGENES
TARGET ORGANISM->INHIBITOR
STREPTOCOCCUS PNEUMONIAE
TARGET ORGANISM->INHIBITOR
Related Record Type Details
Structure of RU-72365
METABOLITE -> PARENT
FECAL
Structure of RU-72365
METABOLITE -> PARENT
URINE
Structure of RU-76584
METABOLITE -> PARENT
URINE
Structure of RU-76584
METABOLITE -> PARENT
PLASMA
Structure of 2H-OXACYCLOTETRADECINO(4,3-D)OXAZOLE-2,6,8,14(1H,7H,9H)-TETRONE, 4-ETHYLOCTAHYDRO-1-(4-HYDROXYBUTYL)-11-METHOXY-3A,7,9,11,13,15-HEXAMETHYL-10-((3,4,6-TRIDEOXY-3-(DIMETHYLAMINO)-.BETA.-D-XYLO-HEXOPYRANOSYL)OXY)-, (3AS,4R,7R,9R,10R,11R,13R,15R,15AR)-
METABOLITE -> PARENT
URINE
Structure of RU-72365
METABOLITE -> PARENT
PLASMA
Structure of RU-76584
METABOLITE -> PARENT
FECAL
Structure of 2H-OXACYCLOTETRADECINO(4,3-D)OXAZOLE-2,6,8,14(1H,7H,9H)-TETRONE, 4-ETHYLOCTAHYDRO-1-(4-HYDROXYBUTYL)-11-METHOXY-3A,7,9,11,13,15-HEXAMETHYL-10-((3,4,6-TRIDEOXY-3-(DIMETHYLAMINO)-.BETA.-D-XYLO-HEXOPYRANOSYL)OXY)-, (3AS,4R,7R,9R,10R,11R,13R,15R,15AR)-
METABOLITE -> PARENT
FECAL
Structure of 2H-OXACYCLOTETRADECINO(4,3-D)OXAZOLE-2,6,8,14(1H,7H,9H)-TETRONE, 4-ETHYLOCTAHYDRO-1-(4-HYDROXYBUTYL)-11-METHOXY-3A,7,9,11,13,15-HEXAMETHYL-10-((3,4,6-TRIDEOXY-3-(DIMETHYLAMINO)-.BETA.-D-XYLO-HEXOPYRANOSYL)OXY)-, (3AS,4R,7R,9R,10R,11R,13R,15R,15AR)-
METABOLITE -> PARENT
PLASMA
Related Record Type Details
Structure of TELITHROMYCIN
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC ORAL ADMINISTRATION

Tmax PHARMACOKINETIC ORAL ADMINISTRATION

Volume of Distribution PHARMACOKINETIC INTRAVENOUS INFUSION

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