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Details

Stereochemistry ACHIRAL
Molecular Formula C23H27FN4O2
Molecular Weight 410.4845
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of RISPERIDONE

SMILES

CC1=C(CCN2CCC(CC2)C3=NOC4=C3C=CC(F)=C4)C(=O)N5CCCCC5=N1

InChI

InChIKey=RAPZEAPATHNIPO-UHFFFAOYSA-N
InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3

HIDE SMILES / InChI
Molecular Formula C23H27FN4O2
Molecular Weight 410.4845
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Sat Dec 16 17:26:08 UTC 2023
Edited
by admin
on Sat Dec 16 17:26:08 UTC 2023
Record UNII
L6UH7ZF8HC
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
RISPERIDONE
INN   USAN  
Official Name English
RISPERIDONE [EP MONOGRAPH]
Common Name English
Risperidone [WHO-DD]
Common Name English
R-64766
Code English
R 64 766
Code English
RISPERIDONE [EP IMPURITY]
Common Name English
RISPERIDONE [USAN]
Common Name English
RISPERIDONE [USP MONOGRAPH]
Common Name English
N05AX08
Code English
RISPERIDONE [USP IMPURITY]
Common Name English
RISPERIDONE [ORANGE BOOK]
Common Name English
R-64,766
Code English
PERSERIS
Brand Name English
RISPERIDONE [HSDB]
Common Name English
RISPERIDONE [USP-RS]
Common Name English
RISPERIDONE [MART.]
Common Name English
RCN3028
Code English
RISPERDAL
Brand Name English
RCN-3028
Code English
RISPERIDONE [JAN]
Common Name English
3-(2-(4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)-1-PIPERIDINYL)ETHYL)-6,7,8,9-TETRAHYDRO-2-METHYL-4H-PYRIDO(1,2-A)PYRIMIDIN-4-ONE
Systematic Name English
R-64-766
Code English
NSC-759895
Code English
UZEDY
Brand Name English
LY-03004
Code English
risperidone [INN]
Common Name English
RYKINDO
Brand Name English
4H-PYRIDO(1,2-A)PYRIMIDIN-4-ONE, 3-(2-(4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)-1-PIPERIDINYL)ETHYL)-6,7,8,9-TETRAHYDRO-2-METHYL-
Systematic Name English
RISPERIDONE [VANDF]
Common Name English
RISPERIDONE [MI]
Common Name English
Classification Tree Code System Code
WHO-ATC N05AX08
Created by admin on Sat Dec 16 17:26:12 UTC 2023 , Edited by admin on Sat Dec 16 17:26:12 UTC 2023
NDF-RT N0000175430
Created by admin on Sat Dec 16 17:26:12 UTC 2023 , Edited by admin on Sat Dec 16 17:26:12 UTC 2023
NCI_THESAURUS C29710
Created by admin on Sat Dec 16 17:26:12 UTC 2023 , Edited by admin on Sat Dec 16 17:26:12 UTC 2023
WHO-VATC QN05AX08
Created by admin on Sat Dec 16 17:26:12 UTC 2023 , Edited by admin on Sat Dec 16 17:26:12 UTC 2023
LIVERTOX NBK548906
Created by admin on Sat Dec 16 17:26:12 UTC 2023 , Edited by admin on Sat Dec 16 17:26:12 UTC 2023
FDA ORPHAN DRUG 326110
Created by admin on Sat Dec 16 17:26:12 UTC 2023 , Edited by admin on Sat Dec 16 17:26:12 UTC 2023
Code System Code Type Description
ChEMBL
CHEMBL85
Created by admin on Sat Dec 16 17:26:12 UTC 2023 , Edited by admin on Sat Dec 16 17:26:12 UTC 2023
PRIMARY
LACTMED
Risperidone
Created by admin on Sat Dec 16 17:26:12 UTC 2023 , Edited by admin on Sat Dec 16 17:26:12 UTC 2023
PRIMARY
EPA CompTox
DTXSID8045193
Created by admin on Sat Dec 16 17:26:12 UTC 2023 , Edited by admin on Sat Dec 16 17:26:12 UTC 2023
PRIMARY
DRUG CENTRAL
2389
Created by admin on Sat Dec 16 17:26:12 UTC 2023 , Edited by admin on Sat Dec 16 17:26:12 UTC 2023
PRIMARY
HSDB
7580
Created by admin on Sat Dec 16 17:26:12 UTC 2023 , Edited by admin on Sat Dec 16 17:26:12 UTC 2023
PRIMARY
SMS_ID
100000092091
Created by admin on Sat Dec 16 17:26:12 UTC 2023 , Edited by admin on Sat Dec 16 17:26:12 UTC 2023
PRIMARY
MERCK INDEX
m9631
Created by admin on Sat Dec 16 17:26:12 UTC 2023 , Edited by admin on Sat Dec 16 17:26:12 UTC 2023
PRIMARY Merck Index
PUBCHEM
5073
Created by admin on Sat Dec 16 17:26:12 UTC 2023 , Edited by admin on Sat Dec 16 17:26:12 UTC 2023
PRIMARY
WIKIPEDIA
RISPERIDONE
Created by admin on Sat Dec 16 17:26:12 UTC 2023 , Edited by admin on Sat Dec 16 17:26:12 UTC 2023
PRIMARY
USAN
BB-19
Created by admin on Sat Dec 16 17:26:12 UTC 2023 , Edited by admin on Sat Dec 16 17:26:12 UTC 2023
PRIMARY
MESH
D018967
Created by admin on Sat Dec 16 17:26:12 UTC 2023 , Edited by admin on Sat Dec 16 17:26:12 UTC 2023
PRIMARY
INN
6085
Created by admin on Sat Dec 16 17:26:12 UTC 2023 , Edited by admin on Sat Dec 16 17:26:12 UTC 2023
PRIMARY
RS_ITEM_NUM
1604654
Created by admin on Sat Dec 16 17:26:12 UTC 2023 , Edited by admin on Sat Dec 16 17:26:12 UTC 2023
PRIMARY
EVMPD
SUB10335MIG
Created by admin on Sat Dec 16 17:26:12 UTC 2023 , Edited by admin on Sat Dec 16 17:26:12 UTC 2023
PRIMARY
CHEBI
8871
Created by admin on Sat Dec 16 17:26:12 UTC 2023 , Edited by admin on Sat Dec 16 17:26:12 UTC 2023
PRIMARY
CAS
106266-06-2
Created by admin on Sat Dec 16 17:26:12 UTC 2023 , Edited by admin on Sat Dec 16 17:26:12 UTC 2023
PRIMARY
DAILYMED
L6UH7ZF8HC
Created by admin on Sat Dec 16 17:26:12 UTC 2023 , Edited by admin on Sat Dec 16 17:26:12 UTC 2023
PRIMARY
RXCUI
35636
Created by admin on Sat Dec 16 17:26:12 UTC 2023 , Edited by admin on Sat Dec 16 17:26:12 UTC 2023
PRIMARY RxNorm
NCI_THESAURUS
C29416
Created by admin on Sat Dec 16 17:26:12 UTC 2023 , Edited by admin on Sat Dec 16 17:26:12 UTC 2023
PRIMARY
IUPHAR
96
Created by admin on Sat Dec 16 17:26:12 UTC 2023 , Edited by admin on Sat Dec 16 17:26:12 UTC 2023
PRIMARY
DRUG BANK
DB00734
Created by admin on Sat Dec 16 17:26:12 UTC 2023 , Edited by admin on Sat Dec 16 17:26:12 UTC 2023
PRIMARY
FDA UNII
L6UH7ZF8HC
Created by admin on Sat Dec 16 17:26:12 UTC 2023 , Edited by admin on Sat Dec 16 17:26:12 UTC 2023
PRIMARY
NSC
759895
Created by admin on Sat Dec 16 17:26:12 UTC 2023 , Edited by admin on Sat Dec 16 17:26:12 UTC 2023
PRIMARY
Related Record Type Details
5-HYDROXYTRYPTAMINE RECEPTOR 4
TARGET->WEAK INHIBITOR
INHIBITOR
Ki
CYTOCHROME P450 2D6
METABOLIC ENZYME -> SUBSTRATE
5-HYDROXYTRYPTAMINE RECEPTOR 7
TARGET -> INHIBITOR
INHIBITOR
Ki
D(3) DOPAMINE RECEPTOR
TARGET->WEAK INHIBITOR
INHIBITOR
Ki
5-HYDROXYTRYPTAMINE RECEPTOR 2C
TARGET -> INHIBITOR
INHIBITOR
Ki
5-HYDROXYTRYPTAMINE RECEPTOR 1D
TARGET -> INHIBITOR
INHIBITOR
Ki
5-HYDROXYTRYPTAMINE RECEPTOR 5A
TARGET->WEAK INHIBITOR
INHIBITOR
Ki
5-HYDROXYTRYPTAMINE RECEPTOR 2A
TARGET -> INHIBITOR
INHIBITOR
Ki
5-HYDROXYTRYPTAMINE RECEPTOR 1B
TARGET -> INHIBITOR
INHIBITOR
Ki
Structure of RISPERIDONE
BASIS OF STRENGTH->SUBSTANCE
ASSAY (TITRATION)
EP
Structure of RISPERIDONE
BASIS OF STRENGTH->SUBSTANCE
ASSAY (HPLC)
USP
MUSCARINIC ACETYLCHOLINE RECEPTOR M5
OFF TARGET->NON-INHIBITOR
5-HYDROXYTRYPTAMINE RECEPTOR 1E
TARGET->WEAK INHIBITOR
INHIBITOR
Ki
ALPHA-2B ADRENERGIC RECEPTOR
TARGET -> INHIBITOR
INHIBITOR
Ki
5-HYDROXYTRYPTAMINE RECEPTOR 6
TARGET->WEAK INHIBITOR
INHIBITOR
Ki
D(1B) DOPAMINE RECEPTOR
TARGET -> INHIBITOR
INHIBITOR
MUSCARINIC ACETYLCHOLINE RECEPTOR M4
OFF-TARGET->NON-AGONIST
Ki
HISTAMINE H1 RECEPTOR
TARGET -> INHIBITOR
INHIBITOR
Ki
ALPHA-2C ADRENERGIC RECEPTOR
TARGET -> INHIBITOR
INHIBITOR
Ki
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
MUSCARINIC ACETYLCHOLINE RECEPTOR M2
OFF TARGET->NON-INHIBITOR
Ki
D(4) DOPAMINE RECEPTOR
TARGET -> ACTIVATOR
INHIBITOR
Ki
D(2) DOPAMINE RECEPTOR
TARGET -> INHIBITOR
INHIBITOR
Ki
Structure of RISPERIDONE HEXANOATE
SALT/SOLVATE -> PARENT
5-HYDROXYTRYPTAMINE RECEPTOR 1A
TARGET->WEAK INHIBITOR
INHIBITOR
Ki
MUSCARINIC ACETYLCHOLINE RECEPTOR M1
OFF TARGET->NON-INHIBITOR
Ki
MUSCARINIC ACETYLCHOLINE RECEPTOR M3
OFF-TARGET->NON-INHIBITOR
HISTAMINE H2 RECEPTOR
TARGET->WEAK INHIBITOR
INHIBITOR
Ki
MULTIDRUG RESISTANCE PROTEIN 1
TRANSPORTER -> SUBSTRATE
INHIBITOR
IC50
Related Record Type Details
Structure of PALIPERIDONE
METABOLITE ACTIVE -> PARENT
MAJOR
PLASMA
Structure of PALIPERIDONE
METABOLITE ACTIVE -> PARENT
in vitro mediators are CYP2D6 and CYP3A4
Related Record Type Details
Structure of PALIPERIDONE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of 6-METHYLRISPERIDONE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of R-56109
IMPURITY -> PARENT
UNSPECIFIED
EP
Structure of DESFLUORO RISPERIDONE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 6-METHYLRISPERIDONE
IMPURITY -> PARENT
not more than the area of the principal peak in the chromatogram obtained with reference solution (b)
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 3-(2-CHLOROETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-4HPYRIDO(1,2-A)PYRIMIDIN-4-ONE
IMPURITY -> PARENT
UNSPECIFIED
EP
Structure of 5-FLUORORISPERIDONE
IMPURITY -> PARENT
not more than the area of the principal peak in the chromatogram obtained with reference solution (b)
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of RISPERIDONE Z-OXIME
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of Risperidone ketone
IMPURITY -> PARENT
Structure of 3-(2-(4-(4-FLUORO-2-(4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)PIPERIDIN-1-YL)BENZOYL)PIPERIDIN-1-YL)ETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO(1,2-A)PYRIMIDIN-4-ONE
IMPURITY -> PARENT
UNSPECIFIED
EP
Structure of 3-(2-(4-((Z)-(4-FLUORO-2-(4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)PIPERIDIN-1-YL)PHENYL)(HYDROXYIMINO)METHYL)PIPERIDIN-1-YL)ETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO(1,2-A)PYRIMIDIN-4-ONE
IMPURITY -> PARENT
UNSPECIFIED
EP
Structure of DES(6-FLUORO-1,2-BENZOXAZOLE)-2,4-DIFLUOROBENZOYL RISPERIDONE
IMPURITY -> PARENT
UNSPECIFIED
EP
Structure of RISPERIDONE Z-OXIME
IMPURITY -> PARENT
not more than the area of the principal peak in the chromatogram obtained with reference solution (b)
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of PALIPERIDONE
IMPURITY -> PARENT
not more than the area of the principal peak in the chromatogram obtained with reference solution (b)
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 2-(2-METHYL-4-OXO-6,7,8,9-TETRAHYDRO-4H-PYRIDO(1,2-A)PYRIMIDIN-3-YL)ETHYL 4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)PIPERIDIN-1-CARBOXYLATE
IMPURITY -> PARENT
UNSPECIFIED
EP
Structure of 5-FLUORORISPERIDONE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of RISPERIDONE E-OXIME
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of RISPERIDONE E-OXIME
IMPURITY -> PARENT
not more than the area of the principal peak in the chromatogram obtained with reference solution (b)
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
Structure of RISPERIDONE
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