PLAZOMICIN

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C25H48N6O10
Molecular Weight	592.6828
Optical Activity	UNSPECIFIED
Defined Stereocenters	12 / 12
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of PLAZOMICIN

Structure Search

SMILES

CN[C@@H]1[C@@H](O)[C@@H](O[C@H]2[C@@H](C[C@H](N)[C@@H](O[C@H]3OC(CNCCO)=CC[C@H]3N)[C@@H]2O)NC(=O)[C@@H](O)CCN)OC[C@]1(C)O

InChI

InChIKey=IYDYFVUFSPQPPV-PEXOCOHZSA-N

InChI=1S/C25H48N6O10/c1-25(37)11-38-24(18(35)21(25)29-2)41-20-15(31-22(36)16(33)5-6-26)9-14(28)19(17(20)34)40-23-13(27)4-3-12(39-23)10-30-7-8-32/h3,13-21,23-24,29-30,32-35,37H,4-11,26-28H2,1-2H3,(H,31,36)/t13-,14+,15-,16+,17+,18-,19-,20+,21-,23-,24-,25+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C25H48N6O10
Molecular Weight	592.6828
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	12 / 12
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 01:40:40 UTC 2023` Edited by `admin` on `Sat Dec 16 01:40:40 UTC 2023`
Record UNII	LYO9XZ250J
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PLAZOMICIN

Official Name

English

(2S)-4-AMINO-N-((1R,2S,3S,4R,5S)-5-AMINO-4-(((2S,3R)-3-AMINO-6-(((2-HYDROXYETHYL)AMINO)METHYL)-3,4-DIHYDRO-2H-PYRAN-2-YL)OXY)-2-((3-DEOXY-4-C-METHYL-3-(METHYLAMINO)-.BETA.-L-ARABINOPYRANOSYL)OXY)-3-HYDROXYCYCLOHEXYL)-2-HYDROXYBUTANAMIDE

Common Name

English

Plazomicin [WHO-DD]

Common Name

English

PLAZOMICIN [MI]

Common Name

English

plazomicin [INN]

Common Name

English

ACHN-490

Code

English

PLAZOMICIN [USAN]

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID001031303

Created by admin on Sat Dec 16 01:40:40 UTC 2023 , Edited by admin on Sat Dec 16 01:40:40 UTC 2023

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FDA UNII

LYO9XZ250J

Created by admin on Sat Dec 16 01:40:40 UTC 2023 , Edited by admin on Sat Dec 16 01:40:40 UTC 2023

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DRUG CENTRAL

5287

Created by admin on Sat Dec 16 01:40:40 UTC 2023 , Edited by admin on Sat Dec 16 01:40:40 UTC 2023

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INN

9522

Created by admin on Sat Dec 16 01:40:40 UTC 2023 , Edited by admin on Sat Dec 16 01:40:40 UTC 2023

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SMS_ID

100000175065

Created by admin on Sat Dec 16 01:40:40 UTC 2023 , Edited by admin on Sat Dec 16 01:40:40 UTC 2023

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WIKIPEDIA

Plazomicin

Created by admin on Sat Dec 16 01:40:40 UTC 2023 , Edited by admin on Sat Dec 16 01:40:40 UTC 2023

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RXCUI

2049549

Created by admin on Sat Dec 16 01:40:40 UTC 2023 , Edited by admin on Sat Dec 16 01:40:40 UTC 2023

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DAILYMED

LYO9XZ250J

Created by admin on Sat Dec 16 01:40:40 UTC 2023 , Edited by admin on Sat Dec 16 01:40:40 UTC 2023

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USAN

YY-39

Created by admin on Sat Dec 16 01:40:40 UTC 2023 , Edited by admin on Sat Dec 16 01:40:40 UTC 2023

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CAS

1154757-24-0

Created by admin on Sat Dec 16 01:40:40 UTC 2023 , Edited by admin on Sat Dec 16 01:40:40 UTC 2023

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MERCK INDEX

m12109

Created by admin on Sat Dec 16 01:40:40 UTC 2023 , Edited by admin on Sat Dec 16 01:40:40 UTC 2023

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NCI_THESAURUS

C174680

Created by admin on Sat Dec 16 01:40:40 UTC 2023 , Edited by admin on Sat Dec 16 01:40:40 UTC 2023

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ChEMBL

CHEMBL1650559

Created by admin on Sat Dec 16 01:40:40 UTC 2023 , Edited by admin on Sat Dec 16 01:40:40 UTC 2023

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LACTMED

Plazomicin

Created by admin on Sat Dec 16 01:40:40 UTC 2023 , Edited by admin on Sat Dec 16 01:40:40 UTC 2023

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PUBCHEM

42613186

Created by admin on Sat Dec 16 01:40:40 UTC 2023 , Edited by admin on Sat Dec 16 01:40:40 UTC 2023

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DRUG BANK

DB12615

Created by admin on Sat Dec 16 01:40:40 UTC 2023 , Edited by admin on Sat Dec 16 01:40:40 UTC 2023

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					LYO9XZ250J

EXCRETED UNCHANGED

Comments:

Following a single IV dose of 15 mg/kg radiolabeled plazomicin, approximately 97.5% of the dose was recovered in the urine as unchanged plazomicin.

Qualification:

URINE

Amount:


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Interaction Type:

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Amount:

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ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC