APOMORPHINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C17H17NO2
Molecular Weight	267.3224
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of APOMORPHINE

Structure Search

SMILES

[H][C@@]12CC3=C(C(O)=C(O)C=C3)C4=C1C(CCN2C)=CC=C4

InChI

InChIKey=VMWNQDUVQKEIOC-CYBMUJFWSA-N

InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C17H17NO2
Molecular Weight	267.3224
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:20:50 UTC 2023` Edited by `admin` on `Fri Dec 15 15:20:50 UTC 2023`
Record UNII	N21FAR7B4S
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

APOMORPHINE

Common Name

English

APOMORPHINUM

Common Name

English

APOMORPHINE [HSDB]

Common Name

English

APOMORPHINE [VANDF]

Common Name

English

VR-040

Code

English

APL-130277

Code

English

Apomorphine [WHO-DD]

Common Name

English

VR040

Code

English

4H-DIBENZO(DE,G)QUINOLINE-10,11-DIOL, 5,6,6A,7-TETRAHYDRO-6-METHYL-, (R)-

Common Name

English

6A.BETA.-APORPHINE-10,11-DIOL

Common Name

English

APOMORPHINUM [HPUS]

Common Name

English

APOMORPHINE [MI]

Common Name

English

(6AR)-5,6,6A,7-TETRAHYDRO-6-METHYL-4H-DIBENZO(DE,G)QUINOLINE-10,11-DIOL

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66884

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

WHO-ATC

G04BE07

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

WHO-VATC

QG04BE07

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

NDF-RT

N0000175580

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

NCI_THESAURUS

C38149

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

LIVERTOX

NBK548143

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

EU-Orphan Drug

EU/3/01/072

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

FDA ORPHAN DRUG

89295

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

WHO-ATC

N04BC07

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

NDF-RT

N0000000117

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

FDA ORPHAN DRUG

107997

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

WHO-VATC

QN04BC07

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

Code System Code Type Description

DRUG BANK

DB00714

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

PRIMARY

MESH

D001058

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

PRIMARY

PUBCHEM

6005

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

PRIMARY

EPA CompTox

DTXSID8022614

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

PRIMARY

EVMPD

SUB12923MIG

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

PRIMARY

ChEMBL

CHEMBL53

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

PRIMARY

IUPHAR

33

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

PRIMARY

ECHA (EC/EINECS)

200-360-0

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

PRIMARY

CAS

58-00-4

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

PRIMARY

MERCK INDEX

m2003

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

PRIMARY

Merck Index

NCI_THESAURUS

C61639

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

PRIMARY

FDA UNII

N21FAR7B4S

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

PRIMARY

LACTMED

Apomorphine

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

PRIMARY

HSDB

3289

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

PRIMARY

CHEBI

48538

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

PRIMARY

DRUG CENTRAL

228

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

PRIMARY

RXCUI

1043

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

PRIMARY

RxNorm

SMS_ID

100000090486

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

PRIMARY

DAILYMED

N21FAR7B4S

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

PRIMARY

WIKIPEDIA

APOMORPHINE

Created by admin on Fri Dec 15 15:20:50 UTC 2023 , Edited by admin on Fri Dec 15 15:20:50 UTC 2023

PRIMARY

Related Record Type Details


					G9XQ9S7T2F

D(3) DOPAMINE RECEPTOR

TARGET -> AGONIST

Comments:

Emax 82% Transfected CHO cells

Qualification:

EC50

Amount:


					RI471QC62V

D(4) DOPAMINE RECEPTOR

TARGET -> AGONIST

Comments:

Emax 45% Emax 82% Transfected CHO cells

Qualification:

EC50

Amount:


					F39049Y068

APOMORPHINE HYDROCHLORIDE

SALT/SOLVATE -> PARENT


					8E4LAA4357

CYTOCHROME P450 2D6

METABOLIC ENZYME -> SUBSTRATE


					L0423Z5LDW

CYTOCHROME P450 2C8

METABOLIC ENZYME -> SUBSTRATE


					VK4SQL11C0

CYTOCHROME P450 1A2

METABOLIC ENZYME -> INDUCER

Qualification:

MAXIMUM FOLD INCREASE

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					9K13MD7A0D

APOMORPHINE HYDROCHLORIDE ANHYDROUS

SALT/SOLVATE -> PARENT


					SEV29N8JND

POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 2

OFF-TARGET->INHIBITOR

Interaction Type:

BINDING

Qualification:

IC50

Amount:


					19GBD6T9L7

D(2) DOPAMINE RECEPTOR

TARGET -> AGONIST

Comments:

D2S Primary receptor interaction.. Emax 79%

Qualification:

EC50

Amount:


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE


					N21FAR7B4S

EXCRETED UNCHANGED

Comments:

INTRAVENOUS ADMINISTRATION

Qualification:

URINE

Amount:

Related Record Type Details


					622ULQ7RBO

APOMORPHINE PALMITATE

PRODRUG -> METABOLITE ACTIVE


					1USW70QZGV

APOMORPHINE DIACETATE

PRODRUG -> METABOLITE ACTIVE

Related Record Type Details


					N21FAR7B4S

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC

Tmax	PHARMACOKINETIC				SUBCUTANEOUS ADMINISTRATION

CSF/PLASMA RATIO	PHARMACOKINETIC				Tmax PHARMACOKINETIC Route of Adminstration PHARMACOKINETIC
Volume of Distribution	PHARMACOKINETIC