THIORIDAZINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C21H26N2S2
Molecular Weight	370.575
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of THIORIDAZINE

Structure Search

SMILES

CSC1=CC2=C(SC3=C(C=CC=C3)N2CCC4CCCCN4C)C=C1

InChI

InChIKey=KLBQZWRITKRQQV-UHFFFAOYSA-N

InChI=1S/C21H26N2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C21H26N2S2
Molecular Weight	370.575
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:30:45 UTC 2023` Edited by `admin` on `Sat Dec 16 16:30:45 UTC 2023`
Record UNII	N3D6TG58NI
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

THIORIDAZINE

Official Name

English

Thioridazine [WHO-DD]

Common Name

English

NOVORIDAZINE

Brand Name

English

MELLARIL-S

Brand Name

English

THIORIDAZINE [MART.]

Common Name

English

THIORIDAZINE [USAN]

Common Name

English

THIORIL

Brand Name

English

MELLERETTE

Common Name

English

(±)-THIORIDAZINE

Common Name

English

DL-THIORIDAZINE

Common Name

English

TP-21

Code

English

THIORIDAZINE PROLONGATUM

Common Name

English

thioridazine [INN]

Common Name

English

THIORIDAZINE [VANDF]

Common Name

English

THIORIDAZINE [EP MONOGRAPH]

Common Name

English

THIORIDAZINE [HSDB]

Common Name

English

THIORIDAZINE [USP MONOGRAPH]

Common Name

English

THIORIDAZINE [MI]

Common Name

English

SONAPAX

Common Name

English

MELLARIL

Brand Name

English

10-[2-(1-Methyl-2-piperidyl)ethyl]-2-(methylthio)phenothiazine

Systematic Name

English

THIORIDAZINE [USP-RS]

Common Name

English

THIORIDAZINE [ORANGE BOOK]

Common Name

English

10H-PHENOTHIAZINE, 10-(2-(1-METHYL-2-PIPERIDINYL)ETHYL)-2-(METHYLTHIO)-

Systematic Name

English

Classification Tree Code System Code

NDF-RT

N0000007544

Created by admin on Sat Dec 16 16:30:46 UTC 2023 , Edited by admin on Sat Dec 16 16:30:46 UTC 2023

NDF-RT

N0000007544

Created by admin on Sat Dec 16 16:30:46 UTC 2023 , Edited by admin on Sat Dec 16 16:30:46 UTC 2023

NDF-RT

N0000007544

Created by admin on Sat Dec 16 16:30:46 UTC 2023 , Edited by admin on Sat Dec 16 16:30:46 UTC 2023

NDF-RT

N0000175746

Created by admin on Sat Dec 16 16:30:46 UTC 2023 , Edited by admin on Sat Dec 16 16:30:46 UTC 2023

WHO-VATC

QN05AC02

Created by admin on Sat Dec 16 16:30:46 UTC 2023 , Edited by admin on Sat Dec 16 16:30:46 UTC 2023

WHO-ATC

N05AC02

Created by admin on Sat Dec 16 16:30:46 UTC 2023 , Edited by admin on Sat Dec 16 16:30:46 UTC 2023

NCI_THESAURUS

C29710

Created by admin on Sat Dec 16 16:30:46 UTC 2023 , Edited by admin on Sat Dec 16 16:30:46 UTC 2023

LIVERTOX

NBK548347

Created by admin on Sat Dec 16 16:30:46 UTC 2023 , Edited by admin on Sat Dec 16 16:30:46 UTC 2023

Code System Code Type Description

RS_ITEM_NUM

1662504

Created by admin on Sat Dec 16 16:30:46 UTC 2023 , Edited by admin on Sat Dec 16 16:30:46 UTC 2023

PRIMARY

PUBCHEM

5452

Created by admin on Sat Dec 16 16:30:46 UTC 2023 , Edited by admin on Sat Dec 16 16:30:46 UTC 2023

PRIMARY

ECHA (EC/EINECS)

200-044-2

Created by admin on Sat Dec 16 16:30:46 UTC 2023 , Edited by admin on Sat Dec 16 16:30:46 UTC 2023

PRIMARY

INN

818

Created by admin on Sat Dec 16 16:30:46 UTC 2023 , Edited by admin on Sat Dec 16 16:30:46 UTC 2023

PRIMARY

ChEMBL

CHEMBL479

Created by admin on Sat Dec 16 16:30:46 UTC 2023 , Edited by admin on Sat Dec 16 16:30:46 UTC 2023

PRIMARY

DRUG BANK

DB00679

Created by admin on Sat Dec 16 16:30:46 UTC 2023 , Edited by admin on Sat Dec 16 16:30:46 UTC 2023

PRIMARY

FDA UNII

N3D6TG58NI

Created by admin on Sat Dec 16 16:30:46 UTC 2023 , Edited by admin on Sat Dec 16 16:30:46 UTC 2023

PRIMARY

CAS

50-52-2

Created by admin on Sat Dec 16 16:30:46 UTC 2023 , Edited by admin on Sat Dec 16 16:30:46 UTC 2023

PRIMARY

WIKIPEDIA

THIORIDAZINE

Created by admin on Sat Dec 16 16:30:46 UTC 2023 , Edited by admin on Sat Dec 16 16:30:46 UTC 2023

PRIMARY

SMS_ID

100000082147

Created by admin on Sat Dec 16 16:30:46 UTC 2023 , Edited by admin on Sat Dec 16 16:30:46 UTC 2023

PRIMARY

HSDB

3189

Created by admin on Sat Dec 16 16:30:46 UTC 2023 , Edited by admin on Sat Dec 16 16:30:46 UTC 2023

PRIMARY

IUPHAR

100

Created by admin on Sat Dec 16 16:30:46 UTC 2023 , Edited by admin on Sat Dec 16 16:30:46 UTC 2023

PRIMARY

RXCUI

10502

Created by admin on Sat Dec 16 16:30:46 UTC 2023 , Edited by admin on Sat Dec 16 16:30:46 UTC 2023

PRIMARY

RxNorm

DAILYMED

N3D6TG58NI

Created by admin on Sat Dec 16 16:30:46 UTC 2023 , Edited by admin on Sat Dec 16 16:30:46 UTC 2023

PRIMARY

MESH

D013881

Created by admin on Sat Dec 16 16:30:46 UTC 2023 , Edited by admin on Sat Dec 16 16:30:46 UTC 2023

PRIMARY

EPA CompTox

DTXSID6023656

Created by admin on Sat Dec 16 16:30:46 UTC 2023 , Edited by admin on Sat Dec 16 16:30:46 UTC 2023

PRIMARY

NCI_THESAURUS

C61971

Created by admin on Sat Dec 16 16:30:46 UTC 2023 , Edited by admin on Sat Dec 16 16:30:46 UTC 2023

PRIMARY

LACTMED

Thioridazine

Created by admin on Sat Dec 16 16:30:46 UTC 2023 , Edited by admin on Sat Dec 16 16:30:46 UTC 2023

PRIMARY

CHEBI

48566

Created by admin on Sat Dec 16 16:30:46 UTC 2023 , Edited by admin on Sat Dec 16 16:30:46 UTC 2023

PRIMARY

DRUG CENTRAL

2637

Created by admin on Sat Dec 16 16:30:46 UTC 2023 , Edited by admin on Sat Dec 16 16:30:46 UTC 2023

PRIMARY

EVMPD

SUB10984MIG

Created by admin on Sat Dec 16 16:30:46 UTC 2023 , Edited by admin on Sat Dec 16 16:30:46 UTC 2023

PRIMARY

CHEBI

9566

Created by admin on Sat Dec 16 16:30:46 UTC 2023 , Edited by admin on Sat Dec 16 16:30:46 UTC 2023

PRIMARY

MERCK INDEX

m10782

Created by admin on Sat Dec 16 16:30:46 UTC 2023 , Edited by admin on Sat Dec 16 16:30:46 UTC 2023

PRIMARY

Merck Index

Related Record Type Details


					N3D6TG58NI

BASIS OF STRENGTH->SUBSTANCE

Interaction Type:

ASSAY (TITRATION)

Qualification:

EP

Amount:


					LR0F81F33L

ALDEHYDE OXIDASE

METABOLIC ENZYME -> INHIBITOR

Qualification:

IC50

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Amount:


					4WCI67NK8M

THIORIDAZINE HYDROCHLORIDE

SALT/SOLVATE -> PARENT


					N3D6TG58NI

BASIS OF STRENGTH->SUBSTANCE

Interaction Type:

ASSAY (TITRATION)

Qualification:

USP

Amount:

Related Record Type Details


					5XE4NWM740

METABOLITE ACTIVE -> PARENT


					7A5S57JJJB

NORTHIORIDAZINE

METABOLITE -> PARENT

Amount:


					5XE4NWM740

METABOLITE ACTIVE -> PARENT

Comments:

Metabolite to parent drug ratio in non-uraemic human plasma. Mesoridazine is twice as potent as the parent drug in man and has been introduced into clinical use as an antipsychotic.

Interaction Type:

METABOLITE TO PARENT DRUG RATIO

Qualification:

PLASMA; URINE

Amount:


					YI69B9MW63

THIORIDAZINE 5-SULFOXIDE

METABOLITE INACTIVE -> PARENT


					5XE4NWM740

METABOLITE ACTIVE -> PARENT

Comments:

Amount excreted in 24 hour period. Percent of dose excreted in urine as metabolite.

Interaction Type:

AMOUNT EXCRETED

Qualification:

URINE

Amount:


					B7599I244X

METABOLITE ACTIVE -> PARENT

Related Record Type Details


					7A5S57JJJB

NORTHIORIDAZINE

IMPURITY -> PARENT

Comments:

UNSPECIFIED

Qualification:

EP


					DB94QP0ZHW

THIORIDAZINE DISULFOXIDE

IMPURITY -> PARENT

Comments:

For the calculation of contents, multiply the peak areas by 1.5

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					5XE4NWM740

IMPURITY -> PARENT

Comments:

For the calculation of contents, multiply the peak areas by 2.4

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					B7599I244X

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					YI69B9MW63

THIORIDAZINE 5-SULFOXIDE

IMPURITY -> PARENT

Comments:

For the calculation of contents, multiply the peak areas by 0.5

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					52T7SJ3G23

THIORIDAZINE DISULFONE

IMPURITY -> PARENT

Comments:

For the calculation of contents, multiply the peak areas by 1.9

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:

Related Record Type Details


					N3D6TG58NI

ACTIVE MOIETY