CILOSTAZOL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H27N5O2
Molecular Weight	369.4607
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

O=C1CCC2=CC(OCCCCC3=NN=NN3C4CCCCC4)=CC=C2N1

InChI

InChIKey=RRGUKTPIGVIEKM-UHFFFAOYSA-N

InChI=1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26)

HIDE SMILES / InChI

Molecular Formula	C20H27N5O2
Molecular Weight	369.4607
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical
Record UNII	N7Z035406B
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

CILOSTAZOL

Official Name

English

6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydrocarbostyril

Common Name

English

CILOSTAZOL [MI]

Common Name

English

OPC-21

Code

English

2(1H)-QUINOLINONE, 6-(4-(1-CYCLOHEXYL-1H-TETRAZOL-5-YL)BUTOXY)-3,4-DIHYDRO-

Systematic Name

English

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Classification Tree

Code System

Code

Enzyme Inhibitor

NCI_THESAURUS

C744

Agent Affecting Blood or Body Fluid

NCI_THESAURUS

C1327

Platelet aggregation inhibitors excl. heparin

WHO-ATC

B01AC23

Claudication

LIVERTOX

NBK547957

Platelet aggregation inhibitors, excl. heparin

WHO-VATC

QB01AC23

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Code System

Code

Type

Description

MESH

C045645

PRIMARY

CAS

73963-72-1

PRIMARY

NCI_THESAURUS

C1051

PRIMARY

CHEBI

31401

PRIMARY

FDA UNII

N7Z035406B

PRIMARY

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					JOC85XIO65

CGMP-INHIBITED 3',5'-CYCLIC PHOSPHODIESTERASE A

TARGET -> INHIBITOR

Amount:


					N7Z035406B

CILOSTAZOL

BASIS OF STRENGTH->SUBSTANCE

Interaction Type:

ASSAY (HPLC)

Qualification:

USP

Amount:

RELATIONSHIP_AMOUNT [98 to 102] WEIGHT PERCENT (limits)


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:

[95 to 98] % (average)


					463NWV9Y86

Cilostazol Dexborneol

SALT/SOLVATE -> PARENT

Amount:

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					142MZU1X6Q

4'-HYDROXYCILOSTAZOL, TRANS-

METABOLITE LESS ACTIVE -> PARENT

Interaction Type:

MAJOR

Qualification:

PLASMA; URINE


					WSU6LPA0KS

OPC-13326

METABOLITE -> PARENT

Interaction Type:

MINOR

Qualification:

PLASMA


					7G50Y5P93W

OPC-13269

METABOLITE -> PARENT

Interaction Type:

MINOR

Qualification:

PLASMA


					7J19HR19TB

3'-HYDROXYCILOSTAZOL, CIS-

METABOLITE -> PARENT

Interaction Type:

MINOR

Qualification:

PLASMA


					HL83KWZ4LH

4'-HYDROXYCILOSTAZOL, CIS-

METABOLITE -> PARENT

Interaction Type:

MINOR

Qualification:

PLASMA

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					5M77W4SPE0

3,4-DEHYDROCILOSTAZOL

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:

RELATIONSHIP_AMOUNT [<0.1] WEIGHT PERCENT (limits)


					2C5NDT39OC

6-HYDROXY-3,4-DIHYDRO-2(1H)-QUINOLINONE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:

RELATIONSHIP_AMOUNT [<0.1] PERCENT PEAK AREA (limits)


					1F485JCT0L

1-(4-(5-CYCLOHEXYL-1H-TETRAZOL-1-YL)BUTYL)-6-(4-(1-CYCLOHEXYL-1H-TETRAZOL-5-YL)BUTOXY)-3,4-DIHYDROQUINOLIN-2(1H)-ONE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:

RELATIONSHIP_AMOUNT [<0.1] WEIGHT PERCENT (limits)

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					N7Z035406B

CILOSTAZOL

ACTIVE MOIETY

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Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC	[11 to 13] hours (average)