DESVENLAFAXINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C16H25NO2
Molecular Weight	263.3752
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of DESVENLAFAXINE

Structure Search

SMILES

CN(C)CC(C1=CC=C(O)C=C1)C2(O)CCCCC2

InChI

InChIKey=KYYIDSXMWOZKMP-UHFFFAOYSA-N

InChI=1S/C16H25NO2/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16/h6-9,15,18-19H,3-5,10-12H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C16H25NO2
Molecular Weight	263.3752
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:26:22 UTC 2023` Edited by `admin` on `Fri Dec 15 16:26:22 UTC 2023`
Record UNII	NG99554ANW
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

DESVENLAFAXINE

Official Name

English

DESVENLAFAXINE [USP-RS]

Common Name

English

desvenlafaxine [INN]

Common Name

English

NEWVEN

Common Name

English

MDD-XR

Common Name

English

D-VENIZ

Common Name

English

DESVENLAFAXINE [USP MONOGRAPH]

Common Name

English

O-DESMETHYLVENLAFAXINE

Common Name

English

DESVENLAFAXINE [MI]

Common Name

English

DESVENLAFAXINE [ORANGE BOOK]

Common Name

English

DESVENLAFAXINE [VANDF]

Common Name

English

Desvenlafaxine [WHO-DD]

Common Name

English

Classification Tree Code System Code

LIVERTOX

286

Created by admin on Fri Dec 15 16:26:22 UTC 2023 , Edited by admin on Fri Dec 15 16:26:22 UTC 2023

NDF-RT

N0000175749

Created by admin on Fri Dec 15 16:26:22 UTC 2023 , Edited by admin on Fri Dec 15 16:26:22 UTC 2023

WHO-ATC

N06AX23

Created by admin on Fri Dec 15 16:26:22 UTC 2023 , Edited by admin on Fri Dec 15 16:26:22 UTC 2023

NDF-RT

N0000000102

Created by admin on Fri Dec 15 16:26:22 UTC 2023 , Edited by admin on Fri Dec 15 16:26:22 UTC 2023

NCI_THESAURUS

C265

Created by admin on Fri Dec 15 16:26:22 UTC 2023 , Edited by admin on Fri Dec 15 16:26:22 UTC 2023

WHO-VATC

QN06AX23

Created by admin on Fri Dec 15 16:26:22 UTC 2023 , Edited by admin on Fri Dec 15 16:26:22 UTC 2023

NDF-RT

N0000000109

Created by admin on Fri Dec 15 16:26:22 UTC 2023 , Edited by admin on Fri Dec 15 16:26:22 UTC 2023

Code System Code Type Description

NCI_THESAURUS

C61703

Created by admin on Fri Dec 15 16:26:22 UTC 2023 , Edited by admin on Fri Dec 15 16:26:22 UTC 2023

PRIMARY

RS_ITEM_NUM

1175751

Created by admin on Fri Dec 15 16:26:22 UTC 2023 , Edited by admin on Fri Dec 15 16:26:22 UTC 2023

PRIMARY

WIKIPEDIA

DESVENLAFAXINE

Created by admin on Fri Dec 15 16:26:22 UTC 2023 , Edited by admin on Fri Dec 15 16:26:22 UTC 2023

PRIMARY

MESH

C086816

Created by admin on Fri Dec 15 16:26:22 UTC 2023 , Edited by admin on Fri Dec 15 16:26:22 UTC 2023

PRIMARY

CHEBI

83527

Created by admin on Fri Dec 15 16:26:22 UTC 2023 , Edited by admin on Fri Dec 15 16:26:22 UTC 2023

PRIMARY

PUBCHEM

125017

Created by admin on Fri Dec 15 16:26:22 UTC 2023 , Edited by admin on Fri Dec 15 16:26:22 UTC 2023

PRIMARY

DRUG BANK

DB06700

Created by admin on Fri Dec 15 16:26:22 UTC 2023 , Edited by admin on Fri Dec 15 16:26:22 UTC 2023

PRIMARY

NDF-RT

N0000182137

Created by admin on Fri Dec 15 16:26:22 UTC 2023 , Edited by admin on Fri Dec 15 16:26:22 UTC 2023

PRIMARY

Cytochrome P450 2D6 Inhibitors [MoA]

DRUG CENTRAL

4380

Created by admin on Fri Dec 15 16:26:22 UTC 2023 , Edited by admin on Fri Dec 15 16:26:22 UTC 2023

PRIMARY

LACTMED

Desvenlafaxine

Created by admin on Fri Dec 15 16:26:22 UTC 2023 , Edited by admin on Fri Dec 15 16:26:22 UTC 2023

PRIMARY

MERCK INDEX

m4207

Created by admin on Fri Dec 15 16:26:22 UTC 2023 , Edited by admin on Fri Dec 15 16:26:22 UTC 2023

PRIMARY

Merck Index

CAS

93413-62-8

Created by admin on Fri Dec 15 16:26:22 UTC 2023 , Edited by admin on Fri Dec 15 16:26:22 UTC 2023

PRIMARY

CAS

130198-07-1

Created by admin on Fri Dec 15 16:26:22 UTC 2023 , Edited by admin on Fri Dec 15 16:26:22 UTC 2023

SUPERSEDED

INN

8361

Created by admin on Fri Dec 15 16:26:22 UTC 2023 , Edited by admin on Fri Dec 15 16:26:22 UTC 2023

PRIMARY

EPA CompTox

DTXSID40869118

Created by admin on Fri Dec 15 16:26:22 UTC 2023 , Edited by admin on Fri Dec 15 16:26:22 UTC 2023

PRIMARY

DAILYMED

NG99554ANW

Created by admin on Fri Dec 15 16:26:22 UTC 2023 , Edited by admin on Fri Dec 15 16:26:22 UTC 2023

PRIMARY

IUPHAR

7158

Created by admin on Fri Dec 15 16:26:22 UTC 2023 , Edited by admin on Fri Dec 15 16:26:22 UTC 2023

PRIMARY

EVMPD

SUB25380

Created by admin on Fri Dec 15 16:26:22 UTC 2023 , Edited by admin on Fri Dec 15 16:26:22 UTC 2023

PRIMARY

SMS_ID

100000089362

Created by admin on Fri Dec 15 16:26:22 UTC 2023 , Edited by admin on Fri Dec 15 16:26:22 UTC 2023

PRIMARY

FDA UNII

NG99554ANW

Created by admin on Fri Dec 15 16:26:22 UTC 2023 , Edited by admin on Fri Dec 15 16:26:22 UTC 2023

PRIMARY

HSDB

7993

Created by admin on Fri Dec 15 16:26:22 UTC 2023 , Edited by admin on Fri Dec 15 16:26:22 UTC 2023

PRIMARY

RXCUI

734064

Created by admin on Fri Dec 15 16:26:22 UTC 2023 , Edited by admin on Fri Dec 15 16:26:22 UTC 2023

PRIMARY

RxNorm

ChEMBL

CHEMBL1118

Created by admin on Fri Dec 15 16:26:22 UTC 2023 , Edited by admin on Fri Dec 15 16:26:22 UTC 2023

PRIMARY

Related Record Type Details


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Amount:


					NG99554ANW

EXCRETED UNCHANGED

Interaction Type:

AMOUNT EXCRETED

Qualification:

URINE

Amount:


					HY5T9WKI4O

O-DESMETHYLVENLAFAXINE, (-)-

ENANTIOMER -> RACEMATE

Amount:


					ZB22ENF0XR

DESVENLAFAXINE SUCCINATE

SALT/SOLVATE -> PARENT

Amount:


					H9E1T0BI90

DESVENLAFAXINE SUCCINATE ANHYDROUS

SALT/SOLVATE -> PARENT

Amount:


					ATX24E9M6L

DESVENLAFAXINE FUMARATE

SALT/SOLVATE -> PARENT

Amount:


					3TP4E4F972

DESVENLAFAXINE HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:


					189BFR45S0

O-DESMETHYLVENLAFAXINE, (+)-

ENANTIOMER -> RACEMATE

Amount:


					R5JHD7L72A

DESVENLAFAXINE FUMARATE MONOHYDRATE

SALT/SOLVATE -> PARENT

Amount:


					ZG9HEJ3BBR

DESVENLAFAXINE BENZOATE

SALT/SOLVATE -> PARENT

Amount:


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE

Amount:

Related Record Type Details


					GRZ5RCB1QG

PARENT -> METABOLITE ACTIVE

Interaction Type:

MAJOR

Amount:


					DYW3W9739Y

N,O-DIDESMETHYLVENLAFAXINE

METABOLITE INACTIVE -> PARENT

Comments:

<5% (NODV and NODV-glucuronide); Unit: percent of amount administered

Interaction Type:

IN-VIVO

Qualification:

URINE

Amount:


					68PDXVEFMN

DESVENLAFAXINE-O-GLUCURONIDE

METABOLITE INACTIVE -> PARENT

Comments:

Unit: percent of amount administered

Interaction Type:

IN-VIVO

Qualification:

URINE

Amount:


					1H23L3816Q

N,O-DIDESMETHYLVENLAFAXINE-GLUCURONIDE

METABOLITE INACTIVE -> PARENT

Comments:

<5% (NODV and NODV-glucuronide combined); Unit: percent of amount administered

Interaction Type:

IN-VIVO

Qualification:

URINE

Amount:


					A7CGH459FN

TOLUDESVENLAFAXINE

PRODRUG -> METABOLITE ACTIVE

Amount:

Related Record Type Details


					GRZ5RCB1QG

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					84ZK5B3ZT6

RAC DEHYDRO-O-DESMETHYL VENLAFAXINE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:

Related Record Type Details


					NG99554ANW

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC				STEADY-STATE INTRAVENOUS ADMINISTRATION

Tmax	PHARMACOKINETIC				ORAL ADMINISTRATION

ORAL BIOAVAILABILITY	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC				ORAL ADMINISTRATION