TIPIRACIL

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H11ClN4O2
Molecular Weight	242.662
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of TIPIRACIL

Structure Search

SMILES

ClC1=C(CN2CCCC2=N)NC(=O)NC1=O

InChI

InChIKey=QQHMKNYGKVVGCZ-UHFFFAOYSA-N

InChI=1S/C9H11ClN4O2/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11/h11H,1-4H2,(H2,12,13,15,16)

HIDE SMILES / InChI

Molecular Formula	C9H11ClN4O2
Molecular Weight	242.662
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 01:41:50 UTC 2023` Edited by `admin` on `Sat Dec 16 01:41:50 UTC 2023`
Record UNII	NGO10K751P
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

TIPIRACIL

Official Name

English

TPI (FREEBASE)

Code

English

TIPIRACIL [USAN]

Common Name

English

tipiracil [INN]

Common Name

English

TIPIRACIL [MI]

Common Name

English

5-Chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4-(1H,3H)-dione

Common Name

English

Tipiracil [WHO-DD]

Common Name

English

MA-1

Code

English

Classification Tree Code System Code

FDA ORPHAN DRUG

564116

Created by admin on Sat Dec 16 01:41:50 UTC 2023 , Edited by admin on Sat Dec 16 01:41:50 UTC 2023

NCI_THESAURUS

C129825

Created by admin on Sat Dec 16 01:41:50 UTC 2023 , Edited by admin on Sat Dec 16 01:41:50 UTC 2023

NDF-RT

N0000191870

Created by admin on Sat Dec 16 01:41:50 UTC 2023 , Edited by admin on Sat Dec 16 01:41:50 UTC 2023

Code System Code Type Description

FDA UNII

NGO10K751P

Created by admin on Sat Dec 16 01:41:50 UTC 2023 , Edited by admin on Sat Dec 16 01:41:50 UTC 2023

PRIMARY

IUPHAR

8696

Created by admin on Sat Dec 16 01:41:50 UTC 2023 , Edited by admin on Sat Dec 16 01:41:50 UTC 2023

PRIMARY

CAS

183204-74-2

Created by admin on Sat Dec 16 01:41:50 UTC 2023 , Edited by admin on Sat Dec 16 01:41:50 UTC 2023

PRIMARY

ChEMBL

CHEMBL235668

Created by admin on Sat Dec 16 01:41:50 UTC 2023 , Edited by admin on Sat Dec 16 01:41:50 UTC 2023

PRIMARY

NCI_THESAURUS

C152646

Created by admin on Sat Dec 16 01:41:50 UTC 2023 , Edited by admin on Sat Dec 16 01:41:50 UTC 2023

PRIMARY

DRUG CENTRAL

4893

Created by admin on Sat Dec 16 01:41:50 UTC 2023 , Edited by admin on Sat Dec 16 01:41:50 UTC 2023

PRIMARY

DRUG BANK

DB09343

Created by admin on Sat Dec 16 01:41:50 UTC 2023 , Edited by admin on Sat Dec 16 01:41:50 UTC 2023

PRIMARY

NDF-RT

N0000191869

Created by admin on Sat Dec 16 01:41:50 UTC 2023 , Edited by admin on Sat Dec 16 01:41:50 UTC 2023

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Thymidine Phosphorylase Inhibitors [MoA]

DAILYMED

NGO10K751P

Created by admin on Sat Dec 16 01:41:50 UTC 2023 , Edited by admin on Sat Dec 16 01:41:50 UTC 2023

PRIMARY

EPA CompTox

DTXSID601025833

Created by admin on Sat Dec 16 01:41:50 UTC 2023 , Edited by admin on Sat Dec 16 01:41:50 UTC 2023

PRIMARY

RXCUI

1670304

Created by admin on Sat Dec 16 01:41:50 UTC 2023 , Edited by admin on Sat Dec 16 01:41:50 UTC 2023

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RxNorm

CHEBI

90879

Created by admin on Sat Dec 16 01:41:50 UTC 2023 , Edited by admin on Sat Dec 16 01:41:50 UTC 2023

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EVMPD

SUB174128

Created by admin on Sat Dec 16 01:41:50 UTC 2023 , Edited by admin on Sat Dec 16 01:41:50 UTC 2023

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WIKIPEDIA

Tipiracil

Created by admin on Sat Dec 16 01:41:50 UTC 2023 , Edited by admin on Sat Dec 16 01:41:50 UTC 2023

PRIMARY

PUBCHEM

6323266

Created by admin on Sat Dec 16 01:41:50 UTC 2023 , Edited by admin on Sat Dec 16 01:41:50 UTC 2023

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SMS_ID

100000160943

Created by admin on Sat Dec 16 01:41:50 UTC 2023 , Edited by admin on Sat Dec 16 01:41:50 UTC 2023

PRIMARY

INN

9500

Created by admin on Sat Dec 16 01:41:50 UTC 2023 , Edited by admin on Sat Dec 16 01:41:50 UTC 2023

PRIMARY

USAN

BC-15

Created by admin on Sat Dec 16 01:41:50 UTC 2023 , Edited by admin on Sat Dec 16 01:41:50 UTC 2023

PRIMARY

MERCK INDEX

m11862

Created by admin on Sat Dec 16 01:41:50 UTC 2023 , Edited by admin on Sat Dec 16 01:41:50 UTC 2023

PRIMARY

Related Record Type Details


					4H59KLQ0A4

TIPIRACIL HYDROCHLORIDE

SALT/SOLVATE -> PARENT


					809M7SX5AE

HUMAN THYMIDINE PHOSPHORYLASE

TARGET -> INHIBITOR


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Comments:

The in vitro protein binding in human plasma is below 8% for tipiracil.

Interaction Type:

BINDING

Amount:


					NGO10K751P

TIPIRACIL

EXCRETED UNCHANGED

Qualification:

URINE

Amount:

Related Record Type Details


					PNS2EUP1Y2

6-(HYDROXYMETHYL)URACIL

METABOLITE -> PARENT

Amount:

Related Record Type Details


					NGO10K751P

TIPIRACIL

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC				SINGLE DOSE ADMINISTRATION

Biological Half-life	PHARMACOKINETIC				SINGLE DOSE ADMINISTRATION