DOXAZOSIN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C23H25N5O5
Molecular Weight	451.4751
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of DOXAZOSIN

Structure Search

SMILES

COC1=CC2=NC(=NC(N)=C2C=C1OC)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4

InChI

InChIKey=RUZYUOTYCVRMRZ-UHFFFAOYSA-N

InChI=1S/C23H25N5O5/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26)

HIDE SMILES / InChI

Molecular Formula	C23H25N5O5
Molecular Weight	451.4751
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:39:35 UTC 2023` Edited by `admin` on `Sat Dec 16 17:39:35 UTC 2023`
Record UNII	NW1291F1W8
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

DOXAZOSIN

Official Name

English

DOXAZOSIN [MI]

Common Name

English

C02CA04

Code

English

1-(4-AMINO-6,7-DIMETHOXY-2-QUINAZOLINYL)-4-(1,4-BENZODIOXAN-2-YLCARBONYL)PIPERAZINE

Systematic Name

English

(±)-DOXAZOSIN

Common Name

English

(4-(4-AMINO-6,7-DIMETHOXY-2-QUINAZOLINYL)-1-PIPERAZINYL)(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)METHANONE

Systematic Name

English

doxazosin [INN]

Common Name

English

PIPERAZINE, 1-(4-AMINO-6,7-DIMETHOXY-2-QUINAZOLINYL)-4-((2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)CARBONYL)-

Systematic Name

English

DOXAZOSIN [VANDF]

Common Name

English

METHANONE, (4-(4-AMINO-6,7-DIMETHOXY-2-QUINAZOLINYL)-1-PIPERAZINYL)(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)-

Systematic Name

English

Doxazosin [WHO-DD]

Common Name

English

UK-33274

Code

English

CARDURA XL

Brand Name

English

Classification Tree Code System Code

NDF-RT

N0000175553

Created by admin on Sat Dec 16 17:39:36 UTC 2023 , Edited by admin on Sat Dec 16 17:39:36 UTC 2023

NDF-RT

N0000000099

Created by admin on Sat Dec 16 17:39:36 UTC 2023 , Edited by admin on Sat Dec 16 17:39:36 UTC 2023

NCI_THESAURUS

C29713

Created by admin on Sat Dec 16 17:39:36 UTC 2023 , Edited by admin on Sat Dec 16 17:39:36 UTC 2023

LIVERTOX

NBK548718

Created by admin on Sat Dec 16 17:39:36 UTC 2023 , Edited by admin on Sat Dec 16 17:39:36 UTC 2023

WHO-VATC

QC02CA04

Created by admin on Sat Dec 16 17:39:36 UTC 2023 , Edited by admin on Sat Dec 16 17:39:36 UTC 2023

WHO-ATC

C02CA04

Created by admin on Sat Dec 16 17:39:36 UTC 2023 , Edited by admin on Sat Dec 16 17:39:36 UTC 2023

NCI_THESAURUS

C29707

Created by admin on Sat Dec 16 17:39:36 UTC 2023 , Edited by admin on Sat Dec 16 17:39:36 UTC 2023

Code System Code Type Description

WIKIPEDIA

DOXAZOSIN

Created by admin on Sat Dec 16 17:39:36 UTC 2023 , Edited by admin on Sat Dec 16 17:39:36 UTC 2023

PRIMARY

DAILYMED

NW1291F1W8

Created by admin on Sat Dec 16 17:39:36 UTC 2023 , Edited by admin on Sat Dec 16 17:39:36 UTC 2023

PRIMARY

RXCUI

49276

Created by admin on Sat Dec 16 17:39:36 UTC 2023 , Edited by admin on Sat Dec 16 17:39:36 UTC 2023

PRIMARY

RxNorm

CAS

74191-85-8

Created by admin on Sat Dec 16 17:39:36 UTC 2023 , Edited by admin on Sat Dec 16 17:39:36 UTC 2023

PRIMARY

PUBCHEM

3157

Created by admin on Sat Dec 16 17:39:36 UTC 2023 , Edited by admin on Sat Dec 16 17:39:36 UTC 2023

PRIMARY

LACTMED

Doxazosin

Created by admin on Sat Dec 16 17:39:36 UTC 2023 , Edited by admin on Sat Dec 16 17:39:36 UTC 2023

PRIMARY

SMS_ID

100000080772

Created by admin on Sat Dec 16 17:39:36 UTC 2023 , Edited by admin on Sat Dec 16 17:39:36 UTC 2023

PRIMARY

INN

5143

Created by admin on Sat Dec 16 17:39:36 UTC 2023 , Edited by admin on Sat Dec 16 17:39:36 UTC 2023

PRIMARY

MERCK INDEX

m4752

Created by admin on Sat Dec 16 17:39:36 UTC 2023 , Edited by admin on Sat Dec 16 17:39:36 UTC 2023

PRIMARY

Merck Index

ChEMBL

CHEMBL707

Created by admin on Sat Dec 16 17:39:36 UTC 2023 , Edited by admin on Sat Dec 16 17:39:36 UTC 2023

PRIMARY

IUPHAR

7170

Created by admin on Sat Dec 16 17:39:36 UTC 2023 , Edited by admin on Sat Dec 16 17:39:36 UTC 2023

PRIMARY

CHEBI

4708

Created by admin on Sat Dec 16 17:39:36 UTC 2023 , Edited by admin on Sat Dec 16 17:39:36 UTC 2023

PRIMARY

DRUG CENTRAL

954

Created by admin on Sat Dec 16 17:39:36 UTC 2023 , Edited by admin on Sat Dec 16 17:39:36 UTC 2023

PRIMARY

NCI_THESAURUS

C61737

Created by admin on Sat Dec 16 17:39:36 UTC 2023 , Edited by admin on Sat Dec 16 17:39:36 UTC 2023

PRIMARY

EPA CompTox

DTXSID7022964

Created by admin on Sat Dec 16 17:39:36 UTC 2023 , Edited by admin on Sat Dec 16 17:39:36 UTC 2023

PRIMARY

MESH

D017292

Created by admin on Sat Dec 16 17:39:36 UTC 2023 , Edited by admin on Sat Dec 16 17:39:36 UTC 2023

PRIMARY

FDA UNII

NW1291F1W8

Created by admin on Sat Dec 16 17:39:36 UTC 2023 , Edited by admin on Sat Dec 16 17:39:36 UTC 2023

PRIMARY

CAS

137888-77-8

Created by admin on Sat Dec 16 17:39:36 UTC 2023 , Edited by admin on Sat Dec 16 17:39:36 UTC 2023

SUPERSEDED

EVMPD

SUB06384MIG

Created by admin on Sat Dec 16 17:39:36 UTC 2023 , Edited by admin on Sat Dec 16 17:39:36 UTC 2023

PRIMARY

DRUG BANK

DB00590

Created by admin on Sat Dec 16 17:39:36 UTC 2023 , Edited by admin on Sat Dec 16 17:39:36 UTC 2023

PRIMARY

Related Record Type Details


					Q7A4S7HOP4

ALPHA-1B ADRENERGIC RECEPTOR

TARGET -> AGONIST

Amount:


					F6HQ441M9W

DOXAZOSIN, (R)-

ENANTIOMER -> RACEMATE


					V916PA1IQJ

DOXAZOSIN, (S)-

ENANTIOMER -> RACEMATE


					P5O3A2DHB2

ALPHA-1D ADRENERGIC RECEPTOR

TARGET -> INHIBITOR


					Y9EDC2483R

DOXAZOSIN HYDROCHLORIDE

SALT/SOLVATE -> PARENT


					Q7A4S7HOP4

ALPHA-1B ADRENERGIC RECEPTOR

TARGET -> INHIBITOR

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					86P6PQK0MU

DOXAZOSIN MESYLATE

SALT/SOLVATE -> PARENT

Related Record Type Details


					S1I8M9BX3P

7'-HYDROXYDOXAZOSIN

METABOLITE -> PARENT

Qualification:

FECAL; URINE


					1U8GNC1CQL

6'-HYDROXYDOXAZOSIN

METABOLITE -> PARENT

Comments:

known active and inactive metabolites of doxazosin were detected


					X8C5VTG33W

2,4-DIAMINO-6,7-DIMETHOXYQUINAZOLINE

METABOLITE -> PARENT

Comments:

known active and inactive metabolites of doxazosin were detected


					7A3LK69CYE

7-HYDROXYDOXAZOSIN

METABOLITE -> PARENT

Qualification:

FECAL; URINE


					X8C5VTG33W

2,4-DIAMINO-6,7-DIMETHOXYQUINAZOLINE

METABOLITE -> PARENT

Interaction Type:

MINOR

Qualification:

FECAL; URINE


					1X8JI3451K

1-(4-AMINO-6,7-DIMETHOXY-2-QUINAZOLINYL)PIPERAZINE

METABOLITE -> PARENT


					1U8GNC1CQL

6'-HYDROXYDOXAZOSIN

METABOLITE -> PARENT

Qualification:

FECAL; URINE

Related Record Type Details


					NW1291F1W8

DOXAZOSIN

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC