LORAZEPAM

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C15H10Cl2N2O2
Molecular Weight	321.158
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of LORAZEPAM

Structure Search

SMILES

OC1N=C(C2=C(Cl)C=CC=C2)C3=C(NC1=O)C=CC(Cl)=C3

InChI

InChIKey=DIWRORZWFLOCLC-UHFFFAOYSA-N

InChI=1S/C15H10Cl2N2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20)

HIDE SMILES / InChI

Molecular Formula	C15H10Cl2N2O2
Molecular Weight	321.158
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:13:02 UTC 2023` Edited by `admin` on `Fri Dec 15 15:13:02 UTC 2023`
Record UNII	O26FZP769L
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

LORAZEPAM

Official Name

English

Lorazepam [WHO-DD]

Common Name

English

7-Chloro-5-(O-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one

Systematic Name

English

LORAZEPAM [MI]

Common Name

English

LORAZEPAM CIV

Common Name

English

ATIVAN

Brand Name

English

LORAZEPAM [EP IMPURITY]

Common Name

English

LORAZEPAM CIV [USP-RS]

Common Name

English

LORAZEPAM [MART.]

Common Name

English

LORAZEPAM [JAN]

Common Name

English

LORAZEPAM [VANDF]

Common Name

English

LORAZEPAM [USAN]

Common Name

English

(±)-7-CHLORO-5-(O-CHLOROPHENYL)-1,3-DIHYDRO-3-HYDROXY-2H-1,4-BENZODIAZEPIN-2-ONE

Common Name

English

LORAZEPAM [USP MONOGRAPH]

Common Name

English

LOREEV XR

Brand Name

English

2H-1,4-BENZODIAZEPIN-2-ONE, 7-CHLORO-5-(2-CHLOROPHENYL)-1,3-DIHYDRO-3-HYDROXY-, (±)-

Systematic Name

English

LORAZEPAM [ORANGE BOOK]

Common Name

English

LORAZEPAM [EP MONOGRAPH]

Common Name

English

LORAZ

Brand Name

English

WY-4036

Code

English

lorazepam [INN]

Common Name

English

Classification Tree Code System Code

NDF-RT

N0000175694

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

DEA NO.

2885

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

WHO-ATC

N05BA06

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

WHO-ESSENTIAL MEDICINES LIST

05

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

NCI_THESAURUS

C1012

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

WHO-VATC

QN05BA06

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

WHO-VATC

QN05BA56

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

LIVERTOX

NBK548563

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

NDF-RT

N0000007542

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

NCI_THESAURUS

C267

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

WHO-ATC

N05BA56

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

Code System Code Type Description

NCI_THESAURUS

C619

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

PRIMARY

ECHA (EC/EINECS)

212-687-6

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

PRIMARY

ChEMBL

CHEMBL580

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

PRIMARY

SMS_ID

100000092162

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

PRIMARY

RXCUI

6470

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

PRIMARY

RxNorm

MESH

D008140

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

PRIMARY

DRUG BANK

DB00186

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

PRIMARY

INN

2809

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

PRIMARY

DAILYMED

O26FZP769L

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

PRIMARY

CHEBI

52993

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

PRIMARY

PUBCHEM

3958

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

PRIMARY

WIKIPEDIA

LORAZEPAM

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

PRIMARY

EPA CompTox

DTXSID7023225

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

PRIMARY

DRUG CENTRAL

1606

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

PRIMARY

MERCK INDEX

m6906

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

PRIMARY

Merck Index

FDA UNII

O26FZP769L

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

PRIMARY

IUPHAR

5884

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

PRIMARY

LACTMED

Lorazepam

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

PRIMARY

CAS

846-49-1

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

PRIMARY

RS_ITEM_NUM

1370305

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

PRIMARY

EVMPD

SUB08582MIG

Created by admin on Fri Dec 15 15:13:02 UTC 2023 , Edited by admin on Fri Dec 15 15:13:02 UTC 2023

PRIMARY

Related Record Type Details


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					O26FZP769L

LORAZEPAM

BASIS OF STRENGTH->SUBSTANCE

Interaction Type:

ASSAY (HPLC)

Qualification:

USP

Amount:


					O26FZP769L

LORAZEPAM

BASIS OF STRENGTH->SUBSTANCE

Interaction Type:

ASSAY (TITRATION)

Qualification:

EP

Amount:


					H6MU343Z6I

LORAZEPAM, (R)-

ENANTIOMER -> RACEMATE


					0VMC8E4D2Y

LORAZEPAM, (S)-

ENANTIOMER -> RACEMATE

Related Record Type Details


					P0G8I56129

LORAZEPAM GLUCURONIDE

METABOLITE INACTIVE -> PARENT


					070818R7PB

2-CHLORODIAZEPAM

PARENT -> METABOLITE

Qualification:

URINE

Amount:

Related Record Type Details


					8RF5NW66M0

6-CHLORO-4-(O-CHLOROPHENYL)-2-QUINAZOLINECARBOXALDEHYDE

IMPURITY -> PARENT

Comments:

UNSPECIFIED

Qualification:

EP


					8EG947OE7V

6-CHLORO-4-(O-CHLOROPHENYL)-2-QUINAZOLINE METHANOL

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					DYN1NC1YTQ

6-CHLORO-4-(O-CHLOROPHENYL)-2-QUINAZOLINECARBOXYLIC ACID

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					G806VEO3KE

2-AMINO-2',5-DICHLOROBENZOPHENONE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					8RF5NW66M0

6-CHLORO-4-(O-CHLOROPHENYL)-2-QUINAZOLINECARBOXALDEHYDE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					G806VEO3KE

2-AMINO-2',5-DICHLOROBENZOPHENONE

IMPURITY -> PARENT

Comments:

UNSPECIFIED

Qualification:

EP


					7A15A4JNHO

7-CHLORO-5-(2-CHLOROPHENYL)-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE 4-OXIDE

IMPURITY -> PARENT

Comments:

UNSPECIFIED

Qualification:

EP


					Y4HA6DWZ18

LORAZEPAM ACETATE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					E88956SKOE

7-CHLORO-5-(2-CHLOROPHENYL)-4,5-DIHYDRO-1H-1,4-BENZODIAZEPINE-2,3-DIONE, (±)-

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					Y4HA6DWZ18

LORAZEPAM ACETATE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:

Related Record Type Details


					O26FZP769L

LORAZEPAM

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Tmax	PHARMACOKINETIC				ORAL, TABLET PHARMACOKINETIC ORAL, SOLUTION PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC

PROTEIN BINDING	PHARMACOKINETIC

Volume of Distribution	PHARMACOKINETIC				RENAL IMPAIRMENT UNDERGOING HEMODIALYSIS PHARMACOKINETIC RENAL IMPAIRMENT PHARMACOKINETIC PEDIATRICS PHARMACOKINETIC NEONATES WITH ASPHYXIA NEONATORUM PHARMACOKINETIC CHILDREN AND ADOLESCENTS WITH ACUTE LYMPHOCYTIC LEUKEMIA PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC				NEONATES WITH ASPHYXIA NEONATORUM (BIRTH TO 1 MONTH) PHARMACOKINETIC CHILDREN WITH ACUTE LYMPHOCYTIC LEUKEMIA (2 TO 12 YEARS) PHARMACOKINETIC RENAL IMPAIRMENT UNDERGOING DIALYSIS PHARMACOKINETIC RENAL IMPAIRMENT PHARMACOKINETIC PEDIATRICS PHARMACOKINETIC ADOLESCENTS WITH ACUTE LYMPHOCYTIC LEUKEMIA (12 TO 18 YEARS) PHARMACOKINETIC

Route of Elimination	PHARMACOKINETIC				RENAL PHARMACOKINETIC

MAXIMUM TOLERATED DOSE	TOXICITY

ORAL BIOAVAILABILITY	PHARMACOKINETIC