ACETAZOLAMIDE

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C4H6N4O3S2
Molecular Weight	222.245
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ACETAZOLAMIDE

Structure Search

SMILES

CC(=O)NC1=NN=C(S1)S(N)(=O)=O

InChI

InChIKey=BZKPWHYZMXOIDC-UHFFFAOYSA-N

InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)

HIDE SMILES / InChI

Molecular Formula	C4H6N4O3S2
Molecular Weight	222.245
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:03:30 UTC 2023` Edited by `admin` on `Fri Dec 15 15:03:30 UTC 2023`
Record UNII	O3FX965V0I
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ACETAZOLAMIDE

Official Name

English

DEFILTRAN

Brand Name

English

Acetazolamide [WHO-DD]

Common Name

English

ATENEZO

Brand Name

English

ACETAZOLAMIDE [USP-RS]

Common Name

English

acetazolamide [INN]

Common Name

English

ACETAZOLAMIDE [MART.]

Common Name

English

NEPHRAMIDE

Common Name

English

ACETAZOLAMIDE [EP MONOGRAPH]

Common Name

English

ACETAZOLAMIDE [HSDB]

Common Name

English

PHONURIT

Common Name

English

ACETAZOLAMIDE [WHO-IP]

Common Name

English

ACETAZOLAMIDE [MI]

Common Name

English

ACETAMOX

Brand Name

English

ACETAZOLAMIDE [JAN]

Common Name

English

DIDOC

Brand Name

English

DIAMOX

Common Name

English

DIURIWAS

Brand Name

English

NSC-145177

Code

English

N-(5-(AMINOSULFONYL)-1,3,4-THIADIAZOL-2-YL)ACETAMIDE

Systematic Name

English

ACETAZOLAMIDE [VANDF]

Common Name

English

ACETAZOLAMIDE [ORANGE BOOK]

Common Name

English

GLAUPAX

Brand Name

English

EDEMOX

Brand Name

English

ACETAMIDE, N-(5-(AMINOSULFONYL)-1,3,4-THIADIAZOL-2-YL)-

Systematic Name

English

DONMOX

Brand Name

English

ACETAZOLAMIDE [USP MONOGRAPH]

Common Name

English

L 579486

Code

English

N-(5-Sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide

Systematic Name

English

ACETAZOLAMIDUM [WHO-IP LATIN]

Common Name

English

ACETAZOLAMIDE [EP IMPURITY]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QS01EC01

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

NCI_THESAURUS

C448

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

NDF-RT

N0000175517

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

CFR

21 CFR 522.44

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

NCI_THESAURUS

C29577

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

WHO-ATC

S01EC01

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

NDF-RT

N0000000235

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

WHO-ESSENTIAL MEDICINES LIST

21.4

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

CFR

21 CFR 520.28

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

LIVERTOX

NBK548664

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

Code System Code Type Description

NSC

145177

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

PRIMARY

CHEBI

50634

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

PRIMARY

LACTMED

Acetazolamide

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

PRIMARY

INN

481

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

PRIMARY

MERCK INDEX

m1322

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

PRIMARY

Merck Index

ChEMBL

CHEMBL20

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

PRIMARY

FDA UNII

O3FX965V0I

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

PRIMARY

CHEBI

31163

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

PRIMARY

EVMPD

SUB05219MIG

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

PRIMARY

MESH

D000086

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

PRIMARY

WIKIPEDIA

ACETAZOLAMIDE

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

PRIMARY

CAS

59-66-5

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

PRIMARY

CHEBI

27690

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

PRIMARY

DAILYMED

O3FX965V0I

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

PRIMARY

HSDB

3002

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

PRIMARY

PUBCHEM

1986

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

PRIMARY

SMS_ID

100000092652

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

PRIMARY

WHO INTERNATIONAL PHARMACPOEIA

ACETAZOLAMIDE

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

PRIMARY

Description: A white, or almost white, crystalline powder; odourless. Solubility: Very slightly soluble in water; slightly soluble in ethanol (~750 g/l) TS; practically insoluble in ether R. Category: Carbonic anhydrase inhibitor. Storage: Acetazolamide should be kept in a well-closed container. Definition: Acetazolamide contains not less than 99.0% and not more than 101.0% of C4H6N4O3S2, calculated with reference to the dried substance.

EPA CompTox

DTXSID7022544

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

PRIMARY

ECHA (EC/EINECS)

200-440-5

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

PRIMARY

NCI_THESAURUS

C28809

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

PRIMARY

DRUG BANK

DB00819

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

PRIMARY

DRUG CENTRAL

56

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

PRIMARY

RS_ITEM_NUM

1005004

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

PRIMARY

IUPHAR

6792

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

PRIMARY

RXCUI

167

Created by admin on Fri Dec 15 15:03:30 UTC 2023 , Edited by admin on Fri Dec 15 15:03:30 UTC 2023

PRIMARY

RxNorm

Related Record Type Details


					A0JY916TKK

CARBONIC ANHYDRASE 9

TARGET -> INHIBITOR

Qualification:

Ki

Amount:


					C11I0OB162

CARBONIC ANHYDRASE 2

TARGET -> INHIBITOR

Qualification:

Ki

Amount:


					I81U7H57XI

OAT-1

TRANSPORTER -> INHIBITOR


					4HZ67LW8L7

OAT-4

TRANSPORTER -> INHIBITOR


					O3FX965V0I

BASIS OF STRENGTH->SUBSTANCE

Interaction Type:

ASSAY (TITRATION)

Qualification:

EP

Amount:


					VWZ0T4JZW1

CARBONIC ANHYDRASE 14

TARGET -> INHIBITOR

Qualification:

Ki

Amount:


					429ZT169UH

ACETAZOLAMIDE SODIUM

SALT/SOLVATE -> PARENT


					17SY4Y94S5

CARBONIC ANHYDRASE 12

TARGET -> INHIBITOR

Qualification:

Ki

Amount:


					JGK1195L8S

CARBONIC ANHYDRASE 13

TARGET -> INHIBITOR

Qualification:

Ki

Amount:


					31F7ZV0E20

CARBONIC ANHYDRASE 1

TARGET -> INHIBITOR

Qualification:

Ki

Amount:


					ZWJ2Y6JZWY

OAT-3

TRANSPORTER -> INHIBITOR


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					8L25HEU6OJ

ACETAZOLAMIDE DISODIUM

SALT/SOLVATE -> PARENT


					718A98KU4P

CARBONIC ANHYDRASE 7

TARGET -> INHIBITOR

Qualification:

Ki

Amount:

Related Record Type Details


					6B8475348K

N-(5-MERCAPTO-1,3,4-THIADIAZOL-2-YL)ACETAMIDE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					FPU5ZTA94I

BIS(5-(ACETYLAMINO)-1,3,4-THIADIAZOLE-2-SULFONYL)AMINE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					R108Y51SMI

5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONIC ACID

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					B1HEG7V21S

5-AMINO-1,3,4-THIADIAZOLE-2-THIOL

IMPURITY -> PARENT

Comments:

UNSPECIFIED IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					53PM486708

N-(5-CHLORO-1,3,4-THIADIAZOL-2-YL)ACETAMIDE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					F687N81LIZ

DESACETYL ACETAZOLAMIDE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					26F2JM0PP8

ACETAMIDOTHIADIAZOLE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					X3OV618DDO

ACETAZOLAMIDE DISULFIDE

IMPURITY -> PARENT

Amount:

Related Record Type Details


					O3FX965V0I

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC