Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C37H48N6O5S2 |
Molecular Weight | 720.944 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)[C@H](NC(=O)N(C)CC1=CSC(=N1)C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC2=CC=CC=C2)NC(=O)OCC3=CN=CS3)CC4=CC=CC=C4
InChI
InChIKey=NCDNCNXCDXHOMX-XGKFQTDJSA-N
InChI=1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1
Molecular Formula | C37H48N6O5S2 |
Molecular Weight | 720.944 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Approval Year
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:29:49 UTC 2023
by
admin
on
Fri Dec 15 15:29:49 UTC 2023
|
Record UNII |
O3J8G9O825
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Record Status |
Validated (UNII)
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Record Version |
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-
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Classification Tree | Code System | Code | ||
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LIVERTOX |
NBK548747
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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WHO-ATC |
J05AR10
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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WHO-ATC |
J05AE03
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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WHO-VATC |
QJ05AE03
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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WHO-VATC |
QJ05AR10
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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WHO-ATC |
J05AP52
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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EMA ASSESSMENT REPORTS |
LOPINAVIR (AUHTORIZED: HIV INFECTIONS)
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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WHO-ATC |
J05AX66
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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FDA ORPHAN DRUG |
549816
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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NCI_THESAURUS |
C97366
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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FDA ORPHAN DRUG |
509215
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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WHO-ESSENTIAL MEDICINES LIST |
6.4.2.3
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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EMA ASSESSMENT REPORTS |
KALETRA (AUTHORIZED: HIV INFECTIONS)
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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WHO-ESSENTIAL MEDICINES LIST |
6.4.2.3 (LPV/R)
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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WHO-ATC |
J05AR23
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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WHO-ATC |
J05AP53
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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NDF-RT |
N0000191001
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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NDF-RT |
N0000175889
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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FDA ORPHAN DRUG |
484715
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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NDF-RT |
N0000000246
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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EMA ASSESSMENT REPORTS |
VIEKIRAX (AUTHORIZED: HEPATITIS C, CHRONIC)
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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WHO-ATC |
J05AX67
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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EMA ASSESSMENT REPORTS |
NORVIR (AUTHORIZED: HIV INFECTIONS)
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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Code System | Code | Type | Description | ||
---|---|---|---|---|---|
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RITONAVIR
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | Description: A white or almost white powder. Solubility: Practically insoluble in water, freely soluble in methanol R, sparingly soluble in acetone R and very slightly soluble in acetonitrile R. Category: Antiretroviral (Protease Inhibitor). Storage: Ritonavir should be kept in a well-closed container, protected from light. Additional information: Ritonavir may exhibit polymorphism. Requirements: Ritonavir contains not less than 98.5 % and not more than 101.0 % of C37H48N6O5S2, calculated with reference to the dried substance. | ||
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O3J8G9O825
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | |||
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CHEMBL163
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | |||
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1604803
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | |||
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7449
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | |||
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SUB10342MIG
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | |||
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RITONAVIR
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | |||
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85762
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | RxNorm | ||
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N0000182137
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | Cytochrome P450 2D6 Inhibitors [MoA] | ||
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N0000182141
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | Cytochrome P450 3A4 Inhibitors [MoA] | ||
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N0000187064
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | Cytochrome P450 2B6 Inducers [MoA] | ||
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DB00503
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | |||
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D019438
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | |||
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Ritonavir
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | |||
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N0000185607
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | Cytochrome P450 2C19 Inducers [MoA] | ||
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2391
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | |||
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N0000191266
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | Cytochrome P450 1A2 Inducers [MoA] | ||
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100000089167
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | |||
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N0000190113
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | Breast Cancer Resistance Protein Inhibitors [MoA] | ||
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45409
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | |||
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N0000185507
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | Cytochrome P450 2C9 Inducers [MoA] | ||
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DTXSID1048627
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | |||
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N0000190117
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | UDP Glucuronosyltransferases Inducers [MoA] | ||
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N0000190118
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | Cytochrome P450 3A Inducers [MoA] | ||
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693184
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | |||
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O3J8G9O825
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | |||
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m9636
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | Merck Index | ||
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N0000190114
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | Cytochrome P450 3A Inhibitors [MoA] | ||
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392622
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | |||
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7160
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | |||
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8804
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | |||
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C1609
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | |||
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155213-67-5
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | |||
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N0000185503
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY | P-Glycoprotein Inhibitors [MoA] | ||
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GG-103
Created by
admin on Fri Dec 15 15:29:49 UTC 2023 , Edited by admin on Fri Dec 15 15:29:49 UTC 2023
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PRIMARY |
Related Record | Type | Details | ||
---|---|---|---|---|
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TRANSPORTER -> INHIBITOR | |||
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TRANSPORTER -> INHIBITOR | |||
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TRANSPORTER -> INHIBITOR | |||
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BASIS OF STRENGTH->SUBSTANCE |
ASSAY (HPLC)
EP
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BINDER->LIGAND |
BINDING
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METABOLIC ENZYME -> INHIBITOR |
POTENT
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METABOLIC ENZYME -> INHIBITOR |
POTENT
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METABOLIC ENZYME -> INHIBITOR |
POTENT
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TRANSPORTER -> INHIBITOR | |||
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METABOLIC ENZYME -> INDUCER |
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TRANSPORTER -> INHIBITOR |
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TRANSPORTER -> INHIBITOR | |||
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BASIS OF STRENGTH->SUBSTANCE |
ASSAY (HPLC)
USP
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TARGET ORGANISM->INHIBITOR |
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TARGET -> INHIBITOR |
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TRANSPORTER -> SUBSTRATE | |||
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TRANSPORTER -> INDUCER |
Related Record | Type | Details | ||
---|---|---|---|---|
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METABOLITE -> PARENT |
MINOR
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METABOLITE INACTIVE -> PARENT |
MINOR
FECAL
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METABOLITE ACTIVE -> PARENT |
37.3% in feces
30.4% in urine
MAJOR
FECAL; URINE
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METABOLITE ACTIVE -> PARENT |
MAJOR
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METABOLITE ACTIVE -> PARENT |
MAJOR
FECAL
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Related Record | Type | Details | ||
---|---|---|---|---|
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IMPURITY -> PARENT |
UNSPECIFIED
EP
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||
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IMPURITY -> PARENT |
UNSPECIFIED
EP
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||
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IMPURITY -> PARENT |
Mixture of BOC-aminoalcohol and isobutoxycarbonyl aminoalcohol- 0.1
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
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||
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
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||
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IMPURITY -> PARENT |
UNSPECIFIED
EP
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||
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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||
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IMPURITY -> PARENT |
UNSPECIFIED
EP
|
||
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
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||
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IMPURITY -> PARENT |
UNSPECIFIED
EP
|
||
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
|
||
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
|
||
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
|
||
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
|
||
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IMPURITY -> PARENT |
Mixture of ureidovaline and N-deacylvaline ritonavir-0.1
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
|
||
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IMPURITY -> PARENT |
UNSPECIFIED
EP
|
||
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
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||
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
|
||
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
|
||
|
IMPURITY -> PARENT |
UNSPECIFIED
EP
|
||
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
|
||
|
IMPURITY -> PARENT |
UNSPECIFIED
EP
|
||
|
IMPURITY -> PARENT |
Mixture of BOC-aminoalcohol and isobutoxycarbonyl aminoalcohol-0.1
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
|
||
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IMPURITY -> PARENT |
UNSPECIFIED
EP
|
||
|
IMPURITY -> PARENT |
Mixture of ureidovaline and N-deacylvaline ritonavir-0.1
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
|
||
|
IMPURITY -> PARENT |
UNSPECIFIED
EP
|
||
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IMPURITY -> PARENT |
UNSPECIFIED
EP
|
||
|
IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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Related Record | Type | Details | ||
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ACTIVE MOIETY |
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Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
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Biological Half-life | PHARMACOKINETIC |
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Volume of Distribution | PHARMACOKINETIC |
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