POZIOTINIB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H21Cl2FN4O3
Molecular Weight	491.342
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of POZIOTINIB

Structure Search

SMILES

COC1=CC2=NC=NC(NC3=CC=C(Cl)C(Cl)=C3F)=C2C=C1OC4CCN(CC4)C(=O)C=C

InChI

InChIKey=LPFWVDIFUFFKJU-UHFFFAOYSA-N

InChI=1S/C23H21Cl2FN4O3/c1-3-20(31)30-8-6-13(7-9-30)33-19-10-14-17(11-18(19)32-2)27-12-28-23(14)29-16-5-4-15(24)21(25)22(16)26/h3-5,10-13H,1,6-9H2,2H3,(H,27,28,29)

HIDE SMILES / InChI

Molecular Formula	C23H21Cl2FN4O3
Molecular Weight	491.342
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:05:19 UTC 2023` Edited by `admin` on `Sat Dec 16 16:05:19 UTC 2023`
Record UNII	OEI6OOU6IK
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

POZIOTINIB

Official Name

English

Poziotinib [WHO-DD]

Common Name

English

NOV-1201

Code

English

2-PROPEN-1-ONE, 1-(4-((4-((3,4-DICHLORO-2-FLUOROPHENYL)AMINO)-7-METHOXY-6-QUINAZOLINYL)OXY)-1-PIPERIDINYL)-

Systematic Name

English

1-(4-((4-(3,4-DICHLORO-2-FLUOROANILINO)-7-METHOXYQUINAZOLIN-6-YL)OXY(PIPERIDIN-1-YL)PROP-2-EN-1-ONE

Common Name

English

HM-781-36B

Code

English

NOV-120101

Code

English

poziotinib [INN]

Common Name

English

HM-781-36

Code

English

POZIOTINIB [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1742

Created by admin on Sat Dec 16 16:05:20 UTC 2023 , Edited by admin on Sat Dec 16 16:05:20 UTC 2023

NCI_THESAURUS

C2167

Created by admin on Sat Dec 16 16:05:20 UTC 2023 , Edited by admin on Sat Dec 16 16:05:20 UTC 2023

NCI_THESAURUS

C129825

Created by admin on Sat Dec 16 16:05:20 UTC 2023 , Edited by admin on Sat Dec 16 16:05:20 UTC 2023

Code System Code Type Description

DRUG BANK

DB12114

Created by admin on Sat Dec 16 16:05:20 UTC 2023 , Edited by admin on Sat Dec 16 16:05:20 UTC 2023

PRIMARY

CAS

1092364-38-9

Created by admin on Sat Dec 16 16:05:20 UTC 2023 , Edited by admin on Sat Dec 16 16:05:20 UTC 2023

PRIMARY

WIKIPEDIA

Poziotinib

Created by admin on Sat Dec 16 16:05:20 UTC 2023 , Edited by admin on Sat Dec 16 16:05:20 UTC 2023

PRIMARY

ChEMBL

CHEMBL3545154

Created by admin on Sat Dec 16 16:05:20 UTC 2023 , Edited by admin on Sat Dec 16 16:05:20 UTC 2023

PRIMARY

PUBCHEM

25127713

Created by admin on Sat Dec 16 16:05:20 UTC 2023 , Edited by admin on Sat Dec 16 16:05:20 UTC 2023

PRIMARY

EPA CompTox

DTXSID80148853

Created by admin on Sat Dec 16 16:05:20 UTC 2023 , Edited by admin on Sat Dec 16 16:05:20 UTC 2023

PRIMARY

NCI_THESAURUS

C98838

Created by admin on Sat Dec 16 16:05:20 UTC 2023 , Edited by admin on Sat Dec 16 16:05:20 UTC 2023

PRIMARY

SMS_ID

100000177756

Created by admin on Sat Dec 16 16:05:20 UTC 2023 , Edited by admin on Sat Dec 16 16:05:20 UTC 2023

PRIMARY

USAN

JK-195

Created by admin on Sat Dec 16 16:05:20 UTC 2023 , Edited by admin on Sat Dec 16 16:05:20 UTC 2023

PRIMARY

FDA UNII

OEI6OOU6IK

Created by admin on Sat Dec 16 16:05:20 UTC 2023 , Edited by admin on Sat Dec 16 16:05:20 UTC 2023

PRIMARY

INN

9736

Created by admin on Sat Dec 16 16:05:20 UTC 2023 , Edited by admin on Sat Dec 16 16:05:20 UTC 2023

PRIMARY

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Amount:


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RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2

TARGET -> INHIBITOR


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RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4

TARGET -> INHIBITOR


					RO03J093CP

EPIDERMAL GROWTH FACTOR RECEPTOR

TARGET -> INHIBITOR


					X4Z7U6JL1C

POZIOTINIB HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Related Record Type Details


					OEI6OOU6IK

ACTIVE MOIETY