GEMIFLOXACIN

Details

Stereochemistry	RACEMIC
Molecular Formula	C18H20FN5O4
Molecular Weight	389.3809
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

SMILES

CO\N=C1/CN(CC1CN)C2=C(F)C=C3C(=O)C(=CN(C4CC4)C3=N2)C(O)=O

InChI

InChIKey=ZRCVYEYHRGVLOC-HYARGMPZSA-N

InChI=1S/C18H20FN5O4/c1-28-22-14-8-23(6-9(14)5-20)17-13(19)4-11-15(25)12(18(26)27)7-24(10-2-3-10)16(11)21-17/h4,7,9-10H,2-3,5-6,8,20H2,1H3,(H,26,27)/b22-14+

HIDE SMILES / InChI

Molecular Formula	C18H20FN5O4
Molecular Weight	389.3809
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	1
Optical Activity	( + / - )

Approval Year

Substance Class	Chemical
Record UNII	OKR68Y0E4T
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

GEMIFLOXACIN

Official Name

English

1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID, 7-(3-(AMINOMETHYL)-4-(METHOXYIMINO)-1-PYRROLIDINYL)-1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-4- OXO-

Common Name

English

gemifloxacin [INN]

Common Name

English

7-(3-AMINOMETHYL-4-METHOXYIMINO-PYRROLIDINE-1-YL)-1-CYCLOPROPYL-6-FLUORO-4-OXO-1,4-DIHYDRO-(1,8)-NAPHTHYRIDINE-3-CARBOXYLIC ACID

Systematic Name

English

GEMIFLOXACIN [VANDF]

Common Name

English

Showing 1 to 5 of 9 entries

Previous1 2Next

Show entries

Classification Tree

Code System

Code

Quinolines

NDF-RT

N0000007606

Antibacterial

LIVERTOX

NBK548790

Fluoroquinolones

WHO-VATC

QJ01MA15

Established Pharmacologic Class

NDF-RT

N0000175937

Antibiotic

NCI_THESAURUS

C795

Showing 1 to 5 of 6 entries

Previous1 2Next

Show entries

Code System

Code

Type

Description

MESH

C103274

PRIMARY

MERCK INDEX

m5693

PRIMARY

Merck Index

RXCUI

138099

PRIMARY

RxNorm

ChEMBL

CHEMBL430

PRIMARY

LACTMED

Gemifloxacin

PRIMARY

Showing 1 to 5 of 19 entries

Previous1 2 3 4Next

Show entries

Related Record

Type

Details


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Comments:

In vitro binding of gemifloxacin to plasma proteins in healthy subjects is approximately 60 to 70% and is concentration independent.

Interaction Type:

BINDING

Amount:

[60 to 70] % (average)


					3U6TN9Y2LD

MYCOPLASMA FERMENTANS

TARGET ORGANISM->INHIBITOR

Comments:

18 STRAINS LESS THE 8 ng/mL for many strains

Qualification:

MIC90

Amount:

8 ng/mL [<8] (average)


					4AF605U6JN

MRP-2

TRANSPORTER -> INHIBITOR


					VJ8JLV45C6

GEMIFLOXACIN, (R)-

ENANTIOMER -> RACEMATE


					X4S9F8RL01

GEMIFLOXACIN MESYLATE

SALT/SOLVATE -> PARENT

Showing 1 to 5 of 6 entries

Previous1 2Next

Show entries

Related Record

Type

Details


					OKR68Y0E4T

GEMIFLOXACIN

ACTIVE MOIETY

Showing 1 to 1 of 1 entries

Previous1Next

Name	Property Type	Amount	Parameters
Tmax	PHARMACOKINETIC	[0.5 to 2] hours (average)	ORAL ADMINISTRATION

Biological Half-life	PHARMACOKINETIC	[4 to 12] hours (average)	AT STEADY-STATE