FELODIPINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C18H19Cl2NO4
Molecular Weight	384.254
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of FELODIPINE

Structure Search

SMILES

CCOC(=O)C1=C(C)NC(C)=C(C1C2=C(Cl)C(Cl)=CC=C2)C(=O)OC

InChI

InChIKey=RZTAMFZIAATZDJ-UHFFFAOYSA-N

InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3

HIDE SMILES / InChI

Molecular Formula	C18H19Cl2NO4
Molecular Weight	384.254
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:08:32 UTC 2023` Edited by `admin` on `Fri Dec 15 15:08:32 UTC 2023`
Record UNII	OL961R6O2C
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

FELODIPINE

Official Name

English

PLENDIL

Brand Name

English

FELODIPINE [USP-RS]

Common Name

English

FELODIPINE [MART.]

Common Name

English

NSC-760343

Code

English

FELODIPINE [VANDF]

Common Name

English

Felodipine [WHO-DD]

Common Name

English

3,5-PYRIDINEDICARBOXYLIC ACID 4-(2,3-DICHLOROPHENYL)-1,4-DIHYDRO-2,6-DIMETHYL-, ETHYL METHYL ESTER, (±)-

Common Name

English

FELODIPINE [ORANGE BOOK]

Common Name

English

FELODIPINE [USAN]

Common Name

English

FELODIPINE [EP MONOGRAPH]

Common Name

English

FELODIPINE [USP MONOGRAPH]

Common Name

English

FELODIPINE [MI]

Common Name

English

LEXXEL COMPONENT FELODIPINE

Common Name

English

FELODIPINE COMPONENT OF LEXXEL

Common Name

English

C08CA02

Code

English

H 154/82

Code

English

felodipine [INN]

Common Name

English

(±)-ETHYL METHYL 4-(2,3-DICHLOROPHENYL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLATE

Systematic Name

English

FELODIPINE [USP IMPURITY]

Common Name

English

FELODIPINE [JAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C333

Created by admin on Fri Dec 15 15:08:32 UTC 2023 , Edited by admin on Fri Dec 15 15:08:32 UTC 2023

WHO-ATC

C08CA02

Created by admin on Fri Dec 15 15:08:32 UTC 2023 , Edited by admin on Fri Dec 15 15:08:32 UTC 2023

WHO-VATC

QC09BB05

Created by admin on Fri Dec 15 15:08:32 UTC 2023 , Edited by admin on Fri Dec 15 15:08:32 UTC 2023

WHO-VATC

QC08CA02

Created by admin on Fri Dec 15 15:08:32 UTC 2023 , Edited by admin on Fri Dec 15 15:08:32 UTC 2023

NDF-RT

N0000007556

Created by admin on Fri Dec 15 15:08:32 UTC 2023 , Edited by admin on Fri Dec 15 15:08:32 UTC 2023

LIVERTOX

NBK548294

Created by admin on Fri Dec 15 15:08:32 UTC 2023 , Edited by admin on Fri Dec 15 15:08:32 UTC 2023

NDF-RT

N0000175421

Created by admin on Fri Dec 15 15:08:32 UTC 2023 , Edited by admin on Fri Dec 15 15:08:32 UTC 2023

NDF-RT

N0000000069

Created by admin on Fri Dec 15 15:08:32 UTC 2023 , Edited by admin on Fri Dec 15 15:08:32 UTC 2023

WHO-ATC

C09BB05

Created by admin on Fri Dec 15 15:08:32 UTC 2023 , Edited by admin on Fri Dec 15 15:08:32 UTC 2023

Code System Code Type Description

NSC

760343

Created by admin on Fri Dec 15 15:08:32 UTC 2023 , Edited by admin on Fri Dec 15 15:08:32 UTC 2023

PRIMARY

CAS

72509-76-3

Created by admin on Fri Dec 15 15:08:32 UTC 2023 , Edited by admin on Fri Dec 15 15:08:32 UTC 2023

PRIMARY

MERCK INDEX

m5257

Created by admin on Fri Dec 15 15:08:32 UTC 2023 , Edited by admin on Fri Dec 15 15:08:32 UTC 2023

PRIMARY

Merck Index

WIKIPEDIA

FELODIPINE

Created by admin on Fri Dec 15 15:08:32 UTC 2023 , Edited by admin on Fri Dec 15 15:08:32 UTC 2023

PRIMARY

DRUG BANK

DB01023

Created by admin on Fri Dec 15 15:08:32 UTC 2023 , Edited by admin on Fri Dec 15 15:08:32 UTC 2023

PRIMARY

DRUG CENTRAL

1142

Created by admin on Fri Dec 15 15:08:32 UTC 2023 , Edited by admin on Fri Dec 15 15:08:32 UTC 2023

PRIMARY

RXCUI

4316

Created by admin on Fri Dec 15 15:08:32 UTC 2023 , Edited by admin on Fri Dec 15 15:08:32 UTC 2023

PRIMARY

RxNorm

MESH

D015736

Created by admin on Fri Dec 15 15:08:32 UTC 2023 , Edited by admin on Fri Dec 15 15:08:32 UTC 2023

PRIMARY

PUBCHEM

3333

Created by admin on Fri Dec 15 15:08:32 UTC 2023 , Edited by admin on Fri Dec 15 15:08:32 UTC 2023

PRIMARY

EPA CompTox

DTXSID4023042

Created by admin on Fri Dec 15 15:08:32 UTC 2023 , Edited by admin on Fri Dec 15 15:08:32 UTC 2023

PRIMARY

RS_ITEM_NUM

1269389

Created by admin on Fri Dec 15 15:08:32 UTC 2023 , Edited by admin on Fri Dec 15 15:08:32 UTC 2023

PRIMARY

EVMPD

SUB11963MIG

Created by admin on Fri Dec 15 15:08:32 UTC 2023 , Edited by admin on Fri Dec 15 15:08:32 UTC 2023

PRIMARY

LACTMED

Felodipine

Created by admin on Fri Dec 15 15:08:32 UTC 2023 , Edited by admin on Fri Dec 15 15:08:32 UTC 2023

PRIMARY

INN

4877

Created by admin on Fri Dec 15 15:08:32 UTC 2023 , Edited by admin on Fri Dec 15 15:08:32 UTC 2023

PRIMARY

DAILYMED

OL961R6O2C

Created by admin on Fri Dec 15 15:08:32 UTC 2023 , Edited by admin on Fri Dec 15 15:08:32 UTC 2023

PRIMARY

CHEBI

585948

Created by admin on Fri Dec 15 15:08:32 UTC 2023 , Edited by admin on Fri Dec 15 15:08:32 UTC 2023

PRIMARY

USAN

X-2

Created by admin on Fri Dec 15 15:08:32 UTC 2023 , Edited by admin on Fri Dec 15 15:08:32 UTC 2023

PRIMARY

FDA UNII

OL961R6O2C

Created by admin on Fri Dec 15 15:08:32 UTC 2023 , Edited by admin on Fri Dec 15 15:08:32 UTC 2023

PRIMARY

IUPHAR

4190

Created by admin on Fri Dec 15 15:08:32 UTC 2023 , Edited by admin on Fri Dec 15 15:08:32 UTC 2023

PRIMARY

SMS_ID

100000089989

Created by admin on Fri Dec 15 15:08:32 UTC 2023 , Edited by admin on Fri Dec 15 15:08:32 UTC 2023

PRIMARY

ChEMBL

CHEMBL1480

Created by admin on Fri Dec 15 15:08:32 UTC 2023 , Edited by admin on Fri Dec 15 15:08:32 UTC 2023

PRIMARY

NCI_THESAURUS

C29046

Created by admin on Fri Dec 15 15:08:32 UTC 2023 , Edited by admin on Fri Dec 15 15:08:32 UTC 2023

PRIMARY

Related Record Type Details


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE


					22ES734693

MULTIDRUG RESISTANCE PROTEIN 1

TRANSPORTER -> INHIBITOR


					LR0F81F33L

ALDEHYDE OXIDASE

METABOLIC ENZYME -> INHIBITOR

Qualification:

IC50

Amount:


					805SU96HKF

CYTOCHROME P450 3A5

METABOLIC ENZYME -> SUBSTRATE


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					OMN899SSSZ

FELODIPINE, (R)-

ENANTIOMER -> RACEMATE

Amount:


					X2HM27A9QK

FELODIPINE, (S)-

ENANTIOMER -> RACEMATE

Amount:


					OIC6NC9Q3P

VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D

TARGET -> INHIBITOR

Related Record Type Details


					1L4A1EP86I

DEHYDROFELODIPINE

METABOLITE -> PARENT

Interaction Type:

MAJOR

Qualification:

PLASMA

Amount:

Related Record Type Details


					1L4A1EP86I

DEHYDROFELODIPINE

IMPURITY -> PARENT

Amount:


					6LQ9G5T4HP

3,5-Dimethyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

IMPURITY -> PARENT

Amount:


					KS8X6G2MLC

3,5-Diethyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

IMPURITY -> PARENT

Amount:

Related Record Type Details


					OL961R6O2C

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC