RESVERATROL

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H12O3
Molecular Weight	228.2433
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure of RESVERATROL

Structure Search

SMILES

OC1=CC=C(\C=C\C2=CC(O)=CC(O)=C2)C=C1

InChI

InChIKey=LUKBXSAWLPMMSZ-OWOJBTEDSA-N

InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+

HIDE SMILES / InChI

Molecular Formula	C14H12O3
Molecular Weight	228.2433
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:24:22 UTC 2023` Edited by `admin` on `Fri Dec 15 16:24:22 UTC 2023`
Record UNII	Q369O8926L
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

RESVERATROL

Official Name

English

Resveratrol [WHO-DD]

Common Name

English

CA 1201

Common Name

English

RESVERATROL(E)-FORM

Common Name

English

RESVIDA

Common Name

English

RESVERATROL [INCI]

Common Name

English

5-((1E)-2-(4-HYDROXYPHENYL)ETHENYL)-1,3-BENZENEDIOL

Systematic Name

English

TRANS-RESVERATROL [USP-RS]

Common Name

English

BIOFORT

Common Name

English

BIA-6-512

Code

English

NSC-327430

Code

English

RESVERATROL [MART.]

Common Name

English

(E)-RESVERATROL

Common Name

English

(E)-5-(P-HYDROXYSTYRYL)RESORCINOL

Common Name

English

SRT 501M

Common Name

English

TRANS-RESVERATROL

Common Name

English

CUSPIDATIN

Common Name

English

RESVERATROL P 5

Common Name

English

Jotrol

Brand Name

English

MELINJO RESVERATROL 20

Common Name

English

BIA 6-512

Code

English

POLYGONIN

Common Name

English

RESVERATROL [HSDB]

Common Name

English

RESVERATROL [VANDF]

Common Name

English

5-((E)-2-(4-HYDROXYPHENYL)-ETHENYL) BENZENE-1,3 DIOL

Systematic Name

English

RESVERATROL [MI]

Common Name

English

Classification Tree Code System Code

EU-Orphan Drug

EU/3/16/1827

Created by admin on Fri Dec 15 16:24:22 UTC 2023 , Edited by admin on Fri Dec 15 16:24:22 UTC 2023

DSLD

438 (Number of products:1077)

Created by admin on Fri Dec 15 16:24:22 UTC 2023 , Edited by admin on Fri Dec 15 16:24:22 UTC 2023

FDA ORPHAN DRUG

597817

Created by admin on Fri Dec 15 16:24:22 UTC 2023 , Edited by admin on Fri Dec 15 16:24:22 UTC 2023

NCI_THESAURUS

C54630

Created by admin on Fri Dec 15 16:24:22 UTC 2023 , Edited by admin on Fri Dec 15 16:24:22 UTC 2023

FDA ORPHAN DRUG

241707

Created by admin on Fri Dec 15 16:24:22 UTC 2023 , Edited by admin on Fri Dec 15 16:24:22 UTC 2023

NCI_THESAURUS

C275

Created by admin on Fri Dec 15 16:24:22 UTC 2023 , Edited by admin on Fri Dec 15 16:24:22 UTC 2023

Code System Code Type Description

RS_ITEM_NUM

1602105

Created by admin on Fri Dec 15 16:24:22 UTC 2023 , Edited by admin on Fri Dec 15 16:24:22 UTC 2023

PRIMARY

GRAS Notification (GRN No.)

224

Created by admin on Fri Dec 15 16:24:22 UTC 2023 , Edited by admin on Fri Dec 15 16:24:22 UTC 2023

PRIMARY

LACTMED

Resveratrol

Created by admin on Fri Dec 15 16:24:22 UTC 2023 , Edited by admin on Fri Dec 15 16:24:22 UTC 2023

PRIMARY

PUBCHEM

445154

Created by admin on Fri Dec 15 16:24:22 UTC 2023 , Edited by admin on Fri Dec 15 16:24:22 UTC 2023

PRIMARY

NSC

327430

Created by admin on Fri Dec 15 16:24:22 UTC 2023 , Edited by admin on Fri Dec 15 16:24:22 UTC 2023

PRIMARY

EVMPD

SUB32889

Created by admin on Fri Dec 15 16:24:22 UTC 2023 , Edited by admin on Fri Dec 15 16:24:22 UTC 2023

PRIMARY

EPA CompTox

DTXSID4031980

Created by admin on Fri Dec 15 16:24:22 UTC 2023 , Edited by admin on Fri Dec 15 16:24:22 UTC 2023

PRIMARY

NCI_THESAURUS

C1215

Created by admin on Fri Dec 15 16:24:22 UTC 2023 , Edited by admin on Fri Dec 15 16:24:22 UTC 2023

PRIMARY

CHEBI

45713

Created by admin on Fri Dec 15 16:24:22 UTC 2023 , Edited by admin on Fri Dec 15 16:24:22 UTC 2023

PRIMARY

CAS

501-36-0

Created by admin on Fri Dec 15 16:24:22 UTC 2023 , Edited by admin on Fri Dec 15 16:24:22 UTC 2023

PRIMARY

HSDB

7571

Created by admin on Fri Dec 15 16:24:22 UTC 2023 , Edited by admin on Fri Dec 15 16:24:22 UTC 2023

PRIMARY

RXCUI

1000492

Created by admin on Fri Dec 15 16:24:22 UTC 2023 , Edited by admin on Fri Dec 15 16:24:22 UTC 2023

PRIMARY

RxNorm

MESH

C059514

Created by admin on Fri Dec 15 16:24:22 UTC 2023 , Edited by admin on Fri Dec 15 16:24:22 UTC 2023

PRIMARY

SMS_ID

100000126143

Created by admin on Fri Dec 15 16:24:22 UTC 2023 , Edited by admin on Fri Dec 15 16:24:22 UTC 2023

PRIMARY

FDA UNII

Q369O8926L

Created by admin on Fri Dec 15 16:24:22 UTC 2023 , Edited by admin on Fri Dec 15 16:24:22 UTC 2023

PRIMARY

DRUG BANK

DB02709

Created by admin on Fri Dec 15 16:24:22 UTC 2023 , Edited by admin on Fri Dec 15 16:24:22 UTC 2023

PRIMARY

WIKIPEDIA

RESVERATROL

Created by admin on Fri Dec 15 16:24:22 UTC 2023 , Edited by admin on Fri Dec 15 16:24:22 UTC 2023

PRIMARY

DAILYMED

Q369O8926L

Created by admin on Fri Dec 15 16:24:22 UTC 2023 , Edited by admin on Fri Dec 15 16:24:22 UTC 2023

PRIMARY

MERCK INDEX

m9549

Created by admin on Fri Dec 15 16:24:22 UTC 2023 , Edited by admin on Fri Dec 15 16:24:22 UTC 2023

PRIMARY

Merck Index

CHEBI

27881

Created by admin on Fri Dec 15 16:24:22 UTC 2023 , Edited by admin on Fri Dec 15 16:24:22 UTC 2023

PRIMARY

Related Record Type Details


					0FY8X1RL72

CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE PDE4A1

TARGET -> INHIBITOR

Comments:

Representative of PDE4

Amount:


					4AF605U6JN

MRP-2

TRANSPORTER -> INHIBITOR

Comments:

inhibited MTX efflux transport in MDR1-MDCK and MRP2-MDCK cellmonolayers, suggesting that the target of drug interaction wasMDR1 andMRP2 in the intestine duringthe absorption process.


					22ES734693

MULTIDRUG RESISTANCE PROTEIN 1

TRANSPORTER -> INHIBITOR

Comments:

inhibited MTX efflux transport in MDR1-MDCK and MRP2-MDCK cellmonolayers, suggesting that the target of drug interaction wasMDR1 andMRP2 in the intestine duringthe absorption process.


					0I353W9H7M

PAEONIA X SUFFRUTICOSA SEED

PARENT -> CONSTITUENT ALWAYS PRESENT

Comments:

Stilbene was determined by means of of a newly developed rapid, sensitive, and accurate HPLC-DAD method.

Amount:


					0OZF0UI2AQ

CYTOCHROME P450 1B1

METABOLIC ENZYME -> SUBSTRATE


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> INHIBITOR

Comments:

6β-hydroxylation of testosterone

Qualification:

IC50

Amount:


					RO8YK136ZE

NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL

TARGET -> ACTIVATOR

Comments:

Resveratrol activates deacetylase activity while inhibiting desuccinylase activity.

Amount:


					I81U7H57XI

OAT-1

TRANSPORTER -> INHIBITOR

Comments:

MTX uptake was markedly inhibited by Res in rat kidney slicesand hOAT1/3-HEK293 cell, indicating that OAT1 and OAT3 were involved in the drug interaction in the kidney


					ZWJ2Y6JZWY

OAT-3

TRANSPORTER -> INHIBITOR

Comments:

MTX uptake was markedly inhibited by Res in rat kidney slicesand hOAT1/3-HEK293 cell, indicating that OAT1 and OAT3 were involved in the drug interaction in the kidney


					ZTU32AE62N

CALCIUM/CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1A

TARGET -> INHIBITOR

Amount:


					JOC85XIO65

CGMP-INHIBITED 3',5'-CYCLIC PHOSPHODIESTERASE A

TARGET -> INHIBITOR

Amount:


					6X543N684K

GRAPE

CONSTITUENT ALWAYS PRESENT -> PARENT


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> INHIBITOR

Comments:

resveratrol inactivated CYP3A4 in a time- and NADPH-dependent manner, with rate (kinact) and affinity (equilibrium dissociation constant for enzyme-inhibitor complex; KI) of 0.2 min−1 and 20 μM, respectively

Interaction Type:

TIME-DEPENDENT INHIBITION

Qualification:

Ki

Amount:


					B5ZXF484DK

SMILAX CHINA ROOT

PARENT -> ACTIVE CONSTITUENT ALWAYS PRESENT

Comments:

Activity against BACE-1 with Ki value of 5.4 x 10-6M and IC50 of 1.5 x 10-5M.

Amount:

Related Record Type Details


					HF1O6B8YOW

RESVERATROL-3-SULFATE

METABOLITE -> PARENT

Interaction Type:

MAJOR


					6KS3LS0D4F

METABOLITE -> PARENT

Comments:

Human liver microsomes (CYP1A2)

Interaction Type:

IN-VITRO

Qualification:

Scientific Literature

Related Record Type Details


					Q369O8926L

ACTIVE MOIETY

Amount: