MELPHALAN

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C13H18Cl2N2O2
Molecular Weight	305.2
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of MELPHALAN

Structure Search

SMILES

N[C@@H](CC1=CC=C(C=C1)N(CCCl)CCCl)C(O)=O

InChI

InChIKey=SGDBTWWWUNNDEQ-LBPRGKRZSA-N

InChI=1S/C13H18Cl2N2O2/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19/h1-4,12H,5-9,16H2,(H,18,19)/t12-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C13H18Cl2N2O2
Molecular Weight	305.2
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:16:41 UTC 2023` Edited by `admin` on `Fri Dec 15 16:16:41 UTC 2023`
Record UNII	Q41OR9510P
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MELPHALAN

Official Name

English

melphalan [INN]

Common Name

English

L-SARCOLYSIN

Common Name

English

Melphalan [WHO-DD]

Common Name

English

NSC-241286

Code

English

MELPHALAN [MI]

Common Name

English

MELPHALAN [MART.]

Common Name

English

NCI-C04853

Code

English

MELPHALAN [JAN]

Common Name

English

SK 15673

Code

English

MELPHALAN [USP MONOGRAPH]

Common Name

English

MELPHALAN [USAN]

Common Name

English

L-3-(P-(BIS(2-CHLOROETHYL)AMINO)PHENYL)ALANINE

Common Name

English

SARCOLYCIN, L-

Common Name

English

MELPHALAN [ORANGE BOOK]

Common Name

English

L-PHENYLALANINE MUSTARD

Common Name

English

MELPHALAN [IARC]

Common Name

English

PHENYLALANINE MUSTARD

Common Name

English

L-PHENYLALANINE, 4-(BIS(2-CHLOROETHYL)AMINO)-

Systematic Name

English

MELPHALAN [HSDB]

Common Name

English

MELPHALAN [EP MONOGRAPH]

Common Name

English

L-PAM

Common Name

English

NSC-8806

Code

English

MELPHALAN [VANDF]

Common Name

English

ALKERAN

Brand Name

English

CB-3025

Code

English

CB 3025

Code

English

SK-15673

Code

English

Classification Tree Code System Code

FDA ORPHAN DRUG

485515

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

NDF-RT

N0000000236

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

NCI_THESAURUS

C697

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

FDA ORPHAN DRUG

64291

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

WHO-ATC

L01AA03

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

NDF-RT

N0000175558

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

WHO-VATC

QL01AA03

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

FDA ORPHAN DRUG

60991

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

FDA ORPHAN DRUG

378112

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

FDA ORPHAN DRUG

270008

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

LIVERTOX

NBK548280

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

FDA ORPHAN DRUG

381412

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

Code System Code Type Description

PUBCHEM

460612

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

PRIMARY

MESH

D008558

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

PRIMARY

EVMPD

SUB08728MIG

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

PRIMARY

RXCUI

6718

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

PRIMARY

RxNorm

WIKIPEDIA

MELPHALAN

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

PRIMARY

CAS

148-82-3

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

PRIMARY

DRUG BANK

DB01042

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

PRIMARY

NCI_THESAURUS

C633

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

PRIMARY

DAILYMED

Q41OR9510P

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

PRIMARY

NSC

241286

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

PRIMARY

SMS_ID

100000091410

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

PRIMARY

CHEBI

28876

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

PRIMARY

IUPHAR

7620

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

PRIMARY

ECHA (EC/EINECS)

205-726-3

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

PRIMARY

EPA CompTox

DTXSID6020804

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

PRIMARY

NSC

8806

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

PRIMARY

DRUG CENTRAL

1678

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

PRIMARY

MERCK INDEX

m7166

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

PRIMARY

Merck Index

FDA UNII

Q41OR9510P

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

PRIMARY

HSDB

3234

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

PRIMARY

ChEMBL

CHEMBL852

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

PRIMARY

INN

745

Created by admin on Fri Dec 15 16:16:41 UTC 2023 , Edited by admin on Fri Dec 15 16:16:41 UTC 2023

PRIMARY

Related Record Type Details


					1VXP4V453T

MELPHALAN HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:

Related Record Type Details


					ESL4D945VL

MONOHYDROXYMELPHALAN

METABOLITE -> PARENT

Amount:


					F70C5K4786

MELPHALAN FLUFENAMIDE

PRODRUG -> METABOLITE ACTIVE

Amount:


					3412470A0V

MELPHALAN FLUFENAMIDE HYDROCHLORIDE

PRODRUG -> METABOLITE ACTIVE

FB8B918966

DIHYDROXYMELPHALAN

METABOLITE -> PARENT

Amount:

Related Record Type Details


					B035PIS86W

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (GC)

Qualification:

EP

Amount:


					W83QP8L98W

4-BIS(2-CHLOROETHYL)AMINO-L-PHENYLALANINE METHYL ESTER

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:

FB8B918966

DIHYDROXYMELPHALAN

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					PWL89DKF98

4-((2-((4-(BIS(2-CHLOROETHYL)AMINO)-L-PHENYLALANYL)OXY)ETHYL)(2-CHLOROETHYL)AMINO)-L-PHENYLALANINE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					5Q37AUV88K

3-CHLOROMELPHALAN

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					ESL4D945VL

MONOHYDROXYMELPHALAN

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					EC76U446FQ

4-MORPHOLIN-4-YL-L-PHENYLALANINE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					H7FES88CVW

(S)-2-AMINO-3-(4-((2-CHLOROETHYL)(2-METHOXYETHYL)AMINO)PHENYL)PROPANOIC ACID

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					STN4ZLF2T6

4-((2-CHLOROETHYL)AMINO)-L-PHENYLALANINE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:

Related Record Type Details


					Q41OR9510P

MELPHALAN

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC				Elimination PHARMACOKINETIC Elimination PHARMACOKINETIC

Tmax	PHARMACOKINETIC		`Q41OR9510P` MELPHALAN

Volume of Distribution	PHARMACOKINETIC