MIDAZOLAM

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H13ClFN3
Molecular Weight	325.767
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of MIDAZOLAM

Structure Search

SMILES

CC1=NC=C2CN=C(C3=C(F)C=CC=C3)C4=C(C=CC(Cl)=C4)N12

InChI

InChIKey=DDLIGBOFAVUZHB-UHFFFAOYSA-N

InChI=1S/C18H13ClFN3/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13/h2-9H,10H2,1H3

HIDE SMILES / InChI

Molecular Formula	C18H13ClFN3
Molecular Weight	325.767
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:48:03 UTC 2023` Edited by `admin` on `Fri Dec 15 15:48:03 UTC 2023`
Record UNII	R60L0SM5BC
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MIDAZOLAM

Official Name

English

Midazolam [WHO-DD]

Common Name

English

MIDAZOLAM [EP MONOGRAPH]

Common Name

English

MIDAZOLAM [MI]

Common Name

English

USL-261

Code

English

MIDAZOLAM [MART.]

Common Name

English

midazolam [INN]

Common Name

English

MIDAZOLAM CIV [USP-RS]

Common Name

English

4H-IMIDAZO(1,5-A)(1,4)BENZODIAZEPINE, 8-CHLORO-6-(2-FLUOROPHENYL)-1-METHYL

Common Name

English

MIDAZOLAM [USP MONOGRAPH]

Common Name

English

MIDAZOLAM CIV

Common Name

English

NAYZILAM

Brand Name

English

MIDAZOLAM [ORANGE BOOK]

Common Name

English

MIDAZOLAM [JAN]

Common Name

English

MIDAZOLAM [VANDF]

Common Name

English

DORMICUM

Brand Name

English

USL261

Code

English

8-CHLORO-6-(2-FLUOROPHENYL)-1-METHYL-4H-IMIDAZO(1,5-A)(1,4)BENZODIAZEPINE

Systematic Name

English

Classification Tree Code System Code

DEA NO.

2884

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

WHO-VATC

QN05CD08

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

FDA ORPHAN DRUG

514115

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

LIVERTOX

NBK548691

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

FDA ORPHAN DRUG

373912

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

WHO-ESSENTIAL MEDICINES LIST

1.3

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

FDA ORPHAN DRUG

622817

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

FDA ORPHAN DRUG

507615

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

NCI_THESAURUS

C1012

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

FDA ORPHAN DRUG

217405

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

WHO-ATC

N05CD08

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

NDF-RT

N0000175694

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

FDA ORPHAN DRUG

508215

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

WHO-ESSENTIAL MEDICINES LIST

8.4

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

FDA ORPHAN DRUG

277809

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

Code System Code Type Description

EPA CompTox

DTXSID5023320

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

PRIMARY

RXCUI

6960

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

PRIMARY

RxNorm

RS_ITEM_NUM

1443599

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

PRIMARY

INN

4497

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

PRIMARY

WIKIPEDIA

MIDAZOLAM

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

PRIMARY

CHEBI

6932

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

PRIMARY

DAILYMED

R60L0SM5BC

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

PRIMARY

NCI_THESAURUS

C62049

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

PRIMARY

MESH

D008874

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

PRIMARY

EVMPD

SUB08950MIG

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

PRIMARY

CAS

59467-70-8

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

PRIMARY

LACTMED

Midazolam

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

PRIMARY

ECHA (EC/EINECS)

261-774-5

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

PRIMARY

DRUG BANK

DB00683

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

PRIMARY

MERCK INDEX

m7531

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

PRIMARY

Merck Index

IUPHAR

3342

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

PRIMARY

CHEBI

6931

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

PRIMARY

PUBCHEM

4192

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

PRIMARY

ChEMBL

CHEMBL655

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

PRIMARY

CHEBI

7581

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

PRIMARY

HSDB

6751

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

PRIMARY

SMS_ID

100000080626

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

PRIMARY

FDA UNII

R60L0SM5BC

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

PRIMARY

DRUG CENTRAL

1802

Created by admin on Fri Dec 15 15:48:04 UTC 2023 , Edited by admin on Fri Dec 15 15:48:04 UTC 2023

PRIMARY

Related Record Type Details


					5APY6NN4AW

CYTOCHROME P450 3A7

METABOLIC ENZYME -> SUBSTRATE


					26VOKG19ST

CYTOCHROME P450 4B1

METABOLIC ENZYME -> SUBSTRATE


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Amount:


					805SU96HKF

CYTOCHROME P450 3A5

METABOLIC ENZYME -> SUBSTRATE


					ONY583280Z

OCT-1

TRANSPORTER -> INHIBITOR


					5APY6NN4AW

CYTOCHROME P450 3A7

METABOLIC ENZYME -> INHIBITOR


					2Z7LDE78YX

URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A4

METABOLIC ENZYME -> SUBSTRATE

Amount:


					W7TTW573JJ

MIDAZOLAM HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE


					77520S18SE

MIDAZOLAM MALEATE

SALT/SOLVATE -> PARENT

Amount:


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> INHIBITOR


					0UY97CSG1T

CYTOCHROME P450 2B6

METABOLIC ENZYME -> SUBSTRATE

Related Record Type Details


					HHX6BAQ2JX

MIDAZOLAM N-GLUCORONIDE

METABOLITE -> PARENT

Amount:


					E5142BN92Z

1′--HYDROXYMIDAZOLAM

METABOLITE ACTIVE -> PARENT

Amount:


					D7MBM57ULU

4-HYDROXYMIDAZOLAM GLUCURONIDE

METABOLITE -> PARENT

Amount:


					3EYB2R97A9

1'-HYDROXYMIDAZOLAM GLUCURONIDE

METABOLITE -> PARENT


					X9U41NXR6M

METABOLITE ACTIVE -> PARENT

Amount:


					LIW2RH792R

4-HYDROXYMIDAZOLAM

METABOLITE -> PARENT

Amount:

Related Record Type Details


					AH884ZF6QL

REDUCED REDUCED MIDAZOLAM

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					P5URY5OSB9

8-CHLORO-6-(O-FLUOROPHENYL)-1-METHYL-4H-IMIDAZO(1,5-A)(1,4)BENZODIAZEPINE-3-CARBOXYLIC ACID

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					4GQH56Z8BK

5,6-DIHYDROMIDAZOLAM

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					X9U41NXR6M

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					S9JC45ZV43

7-CHLORO-5-(2-FLUOROPHENYL)-2,3-DIHYDRO-1H-1,4-BENZODIAZEPINE-2-METHANAMINE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					WP58XDP3TT

REDUCED MIDAZOLAM

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					ST845X9FH4

6-CHLORO-2-METHYL-4-(2-FLUOROPHENYL)QUINAZOLINE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					2ETY6NSN7M

MIDAZOLAM 6H-ISOMER

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					YEZ8K7P8JQ

DESFLUOROMIDAZOLAM

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					SP3M57VEE5

MIDAZOLAM 5-OXIDE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:

Related Record Type Details


					R60L0SM5BC

MIDAZOLAM

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC