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Details

Stereochemistry ACHIRAL
Molecular Formula C25H22N4O4
Molecular Weight 442.4666
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of ELTROMBOPAG

SMILES

CC1=NN(C(=O)\C1=N/NC2=C(O)C(=CC=C2)C3=CC(=CC=C3)C(O)=O)C4=CC=C(C)C(C)=C4

InChI

InChIKey=XDXWLKQMMKQXPV-QYQHSDTDSA-N
InChI=1S/C25H22N4O4/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33/h4-13,26,30H,1-3H3,(H,32,33)/b27-22-

HIDE SMILES / InChI
Molecular Formula C25H22N4O4
Molecular Weight 442.4666
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:26:29 UTC 2023
Edited
by admin
on Fri Dec 15 16:26:29 UTC 2023
Record UNII
S56D65XJ9G
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ELTROMBOPAG
DASH   EMA EPAR   INN   MART.   MI   VANDF   WHO-DD  
INN  
Official Name English
SB497115
Code English
eltrombopag [INN]
Common Name English
ELTROMBOPAG [EMA EPAR]
Common Name English
(1,1'-BIPHENYL)-3-CARBOXYLIC ACID, 3'-((2Z)-(1-(3,4-DIMETHYLPHENYL)-1,5-DIHYDRO-3-METHYL-5-OXO-4H-PYRAZOL-4-YLIDENE)HYDRAZINO)-2'-HYDROXY-
Common Name English
3'-((2Z)-2-(1-(3,4-DIMETHYLPHENYL)-3-METHYL-5-OXO-1,5-DIHYDRO-4H-PYRAZOL-4-YLIDENE)DIAZANYL)-2'-HYDROXYBIPHENYL-3-CARBOXYLIC ACID
Systematic Name English
Eltrombopag [WHO-DD]
Common Name English
(1,1'-BIPHENYL)-3-CARBOXYLIC ACID, 3'-(2-(1-(3,4-DIMETHYLPHENYL)-4,5-DIHYDRO-3-METHYL-5-OXO-1H-PYRAZOL-4-YL)DIAZENYL)-2'-HYDROXY-
Systematic Name English
ELTROMBOPAG [MART.]
Common Name English
ELTROMBOPAG [MI]
Common Name English
ELTROMBOPAG [VANDF]
Common Name English
Classification Tree Code System Code
NDF-RT N0000175969
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
NCI_THESAURUS C78275
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
NDF-RT N0000175968
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
LIVERTOX 344
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
FDA ORPHAN DRUG 251907
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
WHO-VATC QB02BX05
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
FDA ORPHAN DRUG 410213
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
NDF-RT N0000175973
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
NDF-RT N0000175970
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
WHO-ATC B02BX05
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
NDF-RT N0000178368
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
NDF-RT N0000175967
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
Code System Code Type Description
ChEMBL
CHEMBL461101
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
PRIMARY
INN
8655
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
PRIMARY
NCI_THESAURUS
C71634
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
PRIMARY
MESH
C520809
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
PRIMARY
IUPHAR
6961
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
PRIMARY
RXCUI
711942
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
PRIMARY RxNorm
MERCK INDEX
m4879
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
PRIMARY Merck Index
NDF-RT
N0000191277
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
PRIMARY UGT1A6 Inhibitors [MoA]
DAILYMED
S56D65XJ9G
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
PRIMARY
CAS
496775-61-2
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
PRIMARY
NDF-RT
N0000191274
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
PRIMARY UGT2B15 Inhibitors [MoA]
CAS
376591-99-0
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
NON-SPECIFIC STEREOCHEMISTRY
SMS_ID
100000093073
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
PRIMARY
FDA UNII
S56D65XJ9G
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
PRIMARY
NDF-RT
N0000191272
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
PRIMARY UGT1A1 Inhibitors [MoA]
EPA CompTox
DTXSID5057753
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
PRIMARY
EVMPD
SUB30140
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
PRIMARY
HSDB
8212
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
PRIMARY
DRUG CENTRAL
4399
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
PRIMARY
DRUG BANK
DB06210
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
PRIMARY
CAS
2097678-09-4
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
ALTERNATIVE
NDF-RT
N0000191278
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
PRIMARY UGT1A9 Inhibitors [MoA]
WIKIPEDIA
ELTROMBOPAG
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
PRIMARY
NDF-RT
N0000191276
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
PRIMARY UGT1A4 Inhibitors [MoA]
NDF-RT
N0000191275
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
PRIMARY UGT1A3 Inhibitors [MoA]
NDF-RT
N0000190113
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
PRIMARY Breast Cancer Resistance Protein Inhibitors [MoA]
NDF-RT
N0000190107
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
PRIMARY Organic Anion Transporting Polypeptide 1B1 Inhibitors [MoA]
NDF-RT
N0000191273
Created by admin on Fri Dec 15 16:26:29 UTC 2023 , Edited by admin on Fri Dec 15 16:26:29 UTC 2023
PRIMARY UGT2B7 Inhibitors [MoA]
Related Record Type Details
CYTOCHROME P450 2C8
METABOLIC ENZYME -> SUBSTRATE
Structure of ELTROMBOPAG
EXCRETED UNCHANGED
AMOUNT EXCRETED
URINE
Structure of ELTROMBOPAG OLAMINE
SALT/SOLVATE -> PARENT
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
Structure of ELTROMBOPAG CHOLINE
SALT/SOLVATE -> PARENT
Structure of ELTROMBOPAG
EXCRETED UNCHANGED
AMOUNT EXCRETED
FECAL
CYTOCHROME P450 1A2
METABOLIC ENZYME -> SUBSTRATE
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A1
METABOLIC ENZYME -> SUBSTRATE
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A3
METABOLIC ENZYME -> SUBSTRATE
Related Record Type Details
Structure of 3-(3-((2Z)-2-(1-(4-((2-(((4R)-4-AMINO-5-HYDROXY-5-OXO-PENTANOYL)AMINO)-3-(CARBOXYMETHYLAMINO)-3-OXO-PROPYL)SULFANYLMETHYL)-3-METHYL-PHENYL)-3-METHYL-5-OXO-PYRAZOL-4-YLIDENE)HYDRAZINO)-2-HYDROXY-PHENYL)BENZOIC ACID
METABOLITE -> PARENT
Three coeluting glutathione-related conjugates of eltrombopag (M5, glutathione; M6, cysteine; and M7, glutamyl cysteine) were also prominent, together accounting for another 21% of the dose in feces.
FECAL
Structure of .BETA.-D-GLUCOPYRANOSIDURONIC ACID, 4-AMINO-1-(3,4-DIMETHYLPHENYL)-3-METHYL-1H-PYRAZOL-5-YL
METABOLITE -> PARENT
URINE
Structure of 3-(2-HYDROXY-3-((2Z)-2-(1-(4-(HYDROXYMETHYL)-3-METHYL-PHENYL)-3-METHYL-5-OXO-PYRAZOL-4-YLIDENE)HYDRAZINO)PHENYL)BENZOIC ACID
METABOLITE -> PARENT
Metabolite M1, a product of mono-oxygenation of eltrombopag, was a minor component, accounting for 1% of total radioactivity at all time points studied.
MINOR
PLASMA
Structure of (2S,3S,4S,5R,6S)-6-(3-(3-((2Z)-2-(1-(3,4-DIMETHYLPHENYL)-3-METHYL-5-OXO-PYRAZOL-4-YLIDENE)HYDRAZINO)-2-HYDROXY-PHENYL)BENZOYL)OXY-3,4,5-TRIHYDROXY-TETRAHYDROPYRAN-2-CARBOXYLIC ACID
METABOLITE -> PARENT
at 24 hours
PLASMA
Structure of 3-(3-((2Z)-2-(1-(4-((2-AMINO-3-HYDROXY-3-OXO-PROPYL)SULFANYLMETHYL)-3-METHYL-PHENYL)-3-METHYL-5-OXO-PYRAZOL-4-YLIDENE)HYDRAZINO)-2-HYDROXY-PHENYL)BENZOIC ACID
METABOLITE -> PARENT
Three coeluting glutathione-related conjugates of eltrombopag (M5, glutathione; M6, cysteine; and M7, glutamyl cysteine) were also prominent, together accounting for another 21% of the dose in the feces.
MAJOR
FECAL
Structure of .BETA.-D-GLUCOPYRANOSIDURONIC ACID, 3-(ACETYLAMINO)-3'-CARBOXY(1,1'-BIPHENYL)-2-YL
METABOLITE -> PARENT
URINE
Related Record Type Details
Structure of ELTROMBOPAG
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Tmax PHARMACOKINETIC ORAL ADMINISTRATION

Volume of Distribution PHARMACOKINETIC
Biological Half-life PHARMACOKINETIC in healthy subjects

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