EDARAVONE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H10N2O
Molecular Weight	174.1992
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of EDARAVONE

Structure Search

SMILES

CC1=NN(C(=O)C1)C2=CC=CC=C2

InChI

InChIKey=QELUYTUMUWHWMC-UHFFFAOYSA-N

InChI=1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3

HIDE SMILES / InChI

Molecular Formula	C10H10N2O
Molecular Weight	174.1992
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 19:32:23 UTC 2023` Edited by `admin` on `Sat Dec 16 19:32:23 UTC 2023`
Record UNII	S798V6YJRP
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

EDARAVONE

Official Name

English

3H-PYRAZOL-3-ONE, 2,4-DIHYDRO-5-METHYL-2-PHENYL-

Systematic Name

English

COLOREX PMP

Brand Name

English

NORPHENAZONE [MI]

Common Name

English

NSC-12

Code

English

NSC-2629

Code

English

C.I. DEVELOPER 1

Common Name

English

NORPHENAZONE

Common Name

English

DEVELOPER Z

Common Name

English

RADICUT

Brand Name

English

EDARAVONE [USAN]

Common Name

English

EDARAVONE [HSDB]

Common Name

English

MCI-186

Code

English

1-PHENYL-3-METHYL-5-PYRAZOLONE

Systematic Name

English

EDARAVONE [ORANGE BOOK]

Common Name

English

RADICAVA

Brand Name

English

NSC-26139

Code

English

JAROCOL PMP

Brand Name

English

3-Methyl-1-phenyl-2-pyrazolin-5-one

Systematic Name

English

PHENAZONE IMPURITY A [EP IMPURITY]

Common Name

English

Edaravone [WHO-DD]

Common Name

English

PHENYL METHYL PYRAZOLONE

Official Name

English

ANTIPYRINE RELATED COMPOUND A [USP-RS]

Common Name

English

EDARAVONE [MART.]

Common Name

English

EDARAVONE [JAN]

Common Name

English

PHENYLMETHYLPYRAZOLONE

Systematic Name

English

PHENYL METHYL PYRAZOLONE [INCI]

Common Name

English

ANTIPYRINE RELATED COMPOUND A [USP IMPURITY]

Common Name

English

edaravone [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1509

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

FDA ORPHAN DRUG

847021

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

WHO-ATC

N07XX14

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

FDA ORPHAN DRUG

478215

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

FDA ORPHAN DRUG

754420

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

EU-Orphan Drug

EU/3/15/1510

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

FDA ORPHAN DRUG

465514

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

Code System Code Type Description

JAPANESE REVIEW

RADICUT

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

PRIMARY

APPROVED JUNE 2015

DRUG BANK

DB12243

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

PRIMARY

RXCUI

1921877

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

PRIMARY

CHEBI

31530

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

PRIMARY

NSC

2629

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

PRIMARY

NSC

12

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

PRIMARY

SMS_ID

100000088126

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

PRIMARY

CAS

89-25-8

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

PRIMARY

MESH

C005435

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

PRIMARY

DAILYMED

S798V6YJRP

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

PRIMARY

ChEMBL

CHEMBL290916

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

PRIMARY

PUBCHEM

4021

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

PRIMARY

NSC

26139

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

PRIMARY

CAS

942-32-5

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

ALTERNATIVE

HSDB

4102

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

PRIMARY

WIKIPEDIA

EDARAVONE

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

PRIMARY

ECHA (EC/EINECS)

201-891-0

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

PRIMARY

CAS

19735-89-8

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

ALTERNATIVE

INN

7362

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

PRIMARY

DRUG CENTRAL

4156

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

PRIMARY

EVMPD

SUB06453MIG

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

PRIMARY

MERCK INDEX

m8072

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

PRIMARY

Merck Index

RS_ITEM_NUM

1040016

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

PRIMARY

ECHA (EC/EINECS)

213-390-4

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

ALTERNATIVE

NCI_THESAURUS

C74323

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

PRIMARY

EPA CompTox

DTXSID9021130

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

PRIMARY

FDA UNII

S798V6YJRP

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

PRIMARY

USAN

DE-18

Created by admin on Sat Dec 16 19:32:27 UTC 2023 , Edited by admin on Sat Dec 16 19:32:27 UTC 2023

PRIMARY

Related Record Type Details


					ZWJ2Y6JZWY

OAT-3

TRANSPORTER -> SUBSTRATE

Amount:


					I81U7H57XI

OAT-1

TRANSPORTER -> SUBSTRATE

Interaction Type:

WEAK


					0M77ZW789J

URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 2B7

METABOLIC ENZYME -> SUBSTRATE


					FGQ0BCJ2G9

URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A6

METABOLIC ENZYME -> SUBSTRATE

Interaction Type:

IN-VITRO

Qualification:

Km

Amount:


					ZWJ2Y6JZWY

OAT-3

TRANSPORTER -> INHIBITOR

Comments:

Edaravone inhib it e d CYP2C9, BCRP, OAT3, and induced CYP1A2 in vitro.

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					2Z7LDE78YX

URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A4

METABOLIC ENZYME -> SUBSTRATE


					IHQ709299P

URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A3

METABOLIC ENZYME -> SUBSTRATE


					O9NNS94T6B

URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 2B4

METABOLIC ENZYME -> SUBSTRATE


					2Z5HW3OR67

URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 2B15

METABOLIC ENZYME -> SUBSTRATE


					VK4SQL11C0

CYTOCHROME P450 1A2

METABOLIC ENZYME -> INDUCER

Comments:

Edaravone inhib it e d CYP2C9, BCRP, OAT3, and induced CYP1A2 in vitro.

Amount:


					W80H4WI8LW

URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 2B17

METABOLIC ENZYME -> SUBSTRATE

Interaction Type:

IN-VITRO

Qualification:

Km

Amount:


					3318TFY23Q

URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A9

METABOLIC ENZYME -> SUBSTRATE

Interaction Type:

IN-VITRO

Qualification:

Km

Amount:


					L9DP834D1P

CYTOCHROME P450 2C9

METABOLIC ENZYME -> INHIBITOR

Comments:

Edaravone inhib it e d CYP2C9, BCRP, OAT3, and induced CYP1A2 in vitro.

Amount:


					S0025AG5ZT

URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A10

METABOLIC ENZYME -> SUBSTRATE


					76UB6O122H

ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2

TRANSPORTER -> INHIBITOR

Comments:

Edaravone inhib it e d CYP2C9, BCRP, OAT3, and induced CYP1A2 in vitro.

Amount:


					HWT82Q8F2V

URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A7

METABOLIC ENZYME -> SUBSTRATE


					0RFO7VC96N

URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A1

METABOLIC ENZYME -> SUBSTRATE


					S5EY2C8G0B

URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A8

METABOLIC ENZYME -> SUBSTRATE

Interaction Type:

IN-VITRO

Qualification:

Km

Amount:

Related Record Type Details


					RQ9RYP03KR

EDARAVONE SULFATE

METABOLITE INACTIVE -> PARENT


					T3CHA1B51H

PARENT -> METABOLITE


					8H49YKB263

EDARAVONE GLUCURONIDE

METABOLITE INACTIVE -> PARENT

Related Record Type Details


					T3CHA1B51H

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					T3CHA1B51H

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:

Related Record Type Details


					S798V6YJRP

EDARAVONE

ACTIVE MOIETY