TRASTUZUMAB EMTANSINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 18:57:25 UTC 2023` Edited by `admin` on `Sat Dec 16 18:57:25 UTC 2023`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	SE2KH7T06F
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ADO-TRASTUZUMAB EMTANSINE

Preferred Name

English

TRASTUZUMAB EMTANSINE

Official Name

English

TDM-1

Code

English

PRO-132365

Code

English

KADCYLA

Brand Name

English

TRASTUZUMAB EMTANSINE [JAN]

Common Name

English

TRASTUZUMAB EMTANSINE [USAN]

Common Name

English

TRASTUZUMAB-MCC-DM1

Code

English

T-DM1

Code

English

TDM1

Code

English

RG-3502

Code

English

TRASTUZUMAB EMTANSINE [MI]

Common Name

English

Trastuzumab emtansine [WHO-DD]

Common Name

English

ADO-TRASTUZUMAB

Common Name

English

ADO-TRASTUZUMAB [VANDF]

Common Name

English

trastuzumab emtansine [INN]

Common Name

English

TRASTUZUMAB EMTANSINE [MART.]

Common Name

English

PRO132365

Code

English

TRASTUZUMAB EMTANSINE (GENETICAL RECOMBINATION)

Official Name

English

ADO-TRASTUZUMAB EMTANSINE [PURPLE BOOK CDER]

Common Name

English

ADO-TRASTUZUMAB EMTANSINE [VANDF]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

412213

Created by admin on Sat Dec 16 18:57:25 UTC 2023 , Edited by admin on Sat Dec 16 18:57:25 UTC 2023

NCI_THESAURUS

C155712

Created by admin on Sat Dec 16 18:57:25 UTC 2023 , Edited by admin on Sat Dec 16 18:57:25 UTC 2023

WHO-VATC

QL01XC14

Created by admin on Sat Dec 16 18:57:25 UTC 2023 , Edited by admin on Sat Dec 16 18:57:25 UTC 2023

WHO-ATC

L01XC14

Created by admin on Sat Dec 16 18:57:25 UTC 2023 , Edited by admin on Sat Dec 16 18:57:25 UTC 2023

EMA ASSESSMENT REPORTS

KADCYLA (AUTHORIZED: BREAST NEOLPLASMA)

Created by admin on Sat Dec 16 18:57:25 UTC 2023 , Edited by admin on Sat Dec 16 18:57:25 UTC 2023

Code System Code Type Description

IUPHAR

6928

Created by admin on Sat Dec 16 18:57:25 UTC 2023 , Edited by admin on Sat Dec 16 18:57:25 UTC 2023

PRIMARY

DRUG BANK

DB05773

Created by admin on Sat Dec 16 18:57:25 UTC 2023 , Edited by admin on Sat Dec 16 18:57:25 UTC 2023

PRIMARY

EVMPD

SUB35467

Created by admin on Sat Dec 16 18:57:25 UTC 2023 , Edited by admin on Sat Dec 16 18:57:25 UTC 2023

PRIMARY

LACTMED

Ado-Trastuzumab Emtansine

Created by admin on Sat Dec 16 18:57:25 UTC 2023 , Edited by admin on Sat Dec 16 18:57:25 UTC 2023

PRIMARY

ChEMBL

CHEMBL1743082

Created by admin on Sat Dec 16 18:57:25 UTC 2023 , Edited by admin on Sat Dec 16 18:57:25 UTC 2023

PRIMARY

NCI_THESAURUS

C82492

Created by admin on Sat Dec 16 18:57:25 UTC 2023 , Edited by admin on Sat Dec 16 18:57:25 UTC 2023

PRIMARY

CAS

1018448-65-1

Created by admin on Sat Dec 16 18:57:25 UTC 2023 , Edited by admin on Sat Dec 16 18:57:25 UTC 2023

PRIMARY

MERCK INDEX

m11006

Created by admin on Sat Dec 16 18:57:25 UTC 2023 , Edited by admin on Sat Dec 16 18:57:25 UTC 2023

PRIMARY

Merck Index

SMS_ID

100000128434

Created by admin on Sat Dec 16 18:57:25 UTC 2023 , Edited by admin on Sat Dec 16 18:57:25 UTC 2023

PRIMARY

DRUG CENTRAL

4990

Created by admin on Sat Dec 16 18:57:25 UTC 2023 , Edited by admin on Sat Dec 16 18:57:25 UTC 2023

PRIMARY

RXCUI

1371041

Created by admin on Sat Dec 16 18:57:25 UTC 2023 , Edited by admin on Sat Dec 16 18:57:25 UTC 2023

PRIMARY

RxNorm

WIKIPEDIA

TRASTUZUMAB EMTANSINE

Created by admin on Sat Dec 16 18:57:25 UTC 2023 , Edited by admin on Sat Dec 16 18:57:25 UTC 2023

PRIMARY

FDA UNII

SE2KH7T06F

Created by admin on Sat Dec 16 18:57:25 UTC 2023 , Edited by admin on Sat Dec 16 18:57:25 UTC 2023

PRIMARY

USAN

WW-66

Created by admin on Sat Dec 16 18:57:25 UTC 2023 , Edited by admin on Sat Dec 16 18:57:25 UTC 2023

PRIMARY

JAPANESE REVIEW

KADCYLA

Created by admin on Sat Dec 16 18:57:25 UTC 2023 , Edited by admin on Sat Dec 16 18:57:25 UTC 2023

PRIMARY

APPROVED SEPTEMBER 2013

INN

9295

Created by admin on Sat Dec 16 18:57:25 UTC 2023 , Edited by admin on Sat Dec 16 18:57:25 UTC 2023

PRIMARY

LACTMED

Trastuzumab Emtansine

Created by admin on Sat Dec 16 18:57:25 UTC 2023 , Edited by admin on Sat Dec 16 18:57:25 UTC 2023

PRIMARY

DAILYMED

SE2KH7T06F

Created by admin on Sat Dec 16 18:57:25 UTC 2023 , Edited by admin on Sat Dec 16 18:57:25 UTC 2023

PRIMARY

ChEMBL

CHEMBL2109399

Created by admin on Sat Dec 16 18:57:25 UTC 2023 , Edited by admin on Sat Dec 16 18:57:25 UTC 2023

PRIMARY

From	To
1_22	1_96
1_147	1_203
1_223	3_214
1_229	2_229
1_232	2_232
1_264	1_324
1_370	1_428
2_22	2_96
2_147	2_203
2_223	4_214
2_264	2_324
2_370	2_428
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_300
N	2_300

Related Record Type Details


					P188ANX8CK

PARENT -> CONJUGATE

Amount:

Related Record Type Details


					6E9CC1P9UA

LYSINE-EMTANSINE

METABOLITE ACTIVE -> PARENT

Comments:

INTERNALIZATION FOLLOWED BY PROTEOLYTIC DIGESTION FORMS ACTIVE METABOLITE WHICH IS UNABLE TO MIGRATE OUT OF CELL LEADING TO AN ENHANCED SAFETY PROFILE

Amount:

Related Record Type Details


					SE2KH7T06F

TRASTUZUMAB EMTANSINE

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
Volume of Distribution	PHARMACOKINETIC

MOL_WEIGHT:ESTIMATED(SDS-PAGE)	CHEMICAL