Colchicine

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H25NO6
Molecular Weight	399.437
Optical Activity	( - )
Additional Stereochemistry	Yes
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0
Stereo Comments	M-helix

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC2=C(C(OC)=C1OC)C3=CC=C(OC)C(=O)C=C3[C@H](CC2)NC(C)=O

InChI

InChIKey=IAKHMKGGTNLKSZ-INIZCTEOSA-N

InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C22H25NO6
Molecular Weight	399.437
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:19:06 UTC 2023` Edited by `admin` on `Fri Dec 15 17:19:06 UTC 2023`
Record UNII	SML2Y3J35T
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Colchicine

Official Name

English

NSC-757

Code

English

COLCHICINUM

Common Name

English

ACETAMIDE, N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO(A)HEPTALEN-7-YL)-,(S)-

Common Name

English

COLCHICINE COMPONENT OF PROBEN-C

Common Name

English

COLCHICINE [WHO-IP]

Common Name

English

(S)-N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO(A)HEPTALEN-7-YL)ACETAMIDE

Systematic Name

English

COLCHICINE [USP MONOGRAPH]

Common Name

English

COLBENEMID COMPONENT COLCHICINE

Common Name

English

COLCHICINE COMPONENT OF COLBENEMID

Common Name

English

COLCHICINE COMPONENT OF COL-PROBENECID

Common Name

English

Colchicine [WHO-DD]

Common Name

English

COLCHICINE [USP-RS]

Common Name

English

COLCHICINE [EP IMPURITY]

Common Name

English

COLCHCINE [VANDF]

Common Name

English

LODOCO

Brand Name

English

GLOPERBA

Brand Name

English

(-)-COLCHICINE

Common Name

English

MITIGARE COMPONENT COLCHICINE

Brand Name

English

PROBEN-C COMPONENT COLCHICINE

Common Name

English

COLCHICINUM [WHO-IP LATIN]

Common Name

English

COLCRYS

Brand Name

English

COLCHINEOS

Common Name

English

COLCHICINE [ORANGE BOOK]

Common Name

English

COLCHICINE COMPONENT OF MITIGARE

Brand Name

English

COLCHICINE [MI]

Common Name

English

COLCHICINUM [HPUS]

Common Name

English

COLCHICINE [EP MONOGRAPH]

Common Name

English

COLCHICINE [JAN]

Common Name

English

COLCHICINE [MART.]

Common Name

English

COL-PROBENECID COMPONENT COLCHICINE

Common Name

English

COLCHISOL

Common Name

English

COLCHICINE [HSDB]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QM04AC01

Created by admin on Fri Dec 15 17:19:07 UTC 2023 , Edited by admin on Fri Dec 15 17:19:07 UTC 2023

FDA ORPHAN DRUG

11085

Created by admin on Fri Dec 15 17:19:07 UTC 2023 , Edited by admin on Fri Dec 15 17:19:07 UTC 2023

FDA ORPHAN DRUG

245707

Created by admin on Fri Dec 15 17:19:07 UTC 2023 , Edited by admin on Fri Dec 15 17:19:07 UTC 2023

FDA ORPHAN DRUG

245807

Created by admin on Fri Dec 15 17:19:07 UTC 2023 , Edited by admin on Fri Dec 15 17:19:07 UTC 2023

NCI_THESAURUS

C67421

Created by admin on Fri Dec 15 17:19:07 UTC 2023 , Edited by admin on Fri Dec 15 17:19:07 UTC 2023

WHO-ATC

M04AC01

Created by admin on Fri Dec 15 17:19:06 UTC 2023 , Edited by admin on Fri Dec 15 17:19:06 UTC 2023

LIVERTOX

NBK548068

Created by admin on Fri Dec 15 17:19:07 UTC 2023 , Edited by admin on Fri Dec 15 17:19:07 UTC 2023

Code System Code Type Description

ECHA (EC/EINECS)

200-598-5

Created by admin on Fri Dec 15 17:19:07 UTC 2023 , Edited by admin on Fri Dec 15 17:19:07 UTC 2023

PRIMARY

HSDB

3044

Created by admin on Fri Dec 15 17:19:07 UTC 2023 , Edited by admin on Fri Dec 15 17:19:07 UTC 2023

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WHO INTERNATIONAL PHARMACOPEIA

COLCHICINE

Created by admin on Fri Dec 15 17:19:07 UTC 2023 , Edited by admin on Fri Dec 15 17:19:07 UTC 2023

PRIMARY

Description: Pale yellow to pale greenish yellow crystals, amorphous scales or a powder; odourless or almost odourless.Solubility: Soluble in water; freely soluble in ethanol (~750 g/l) TS; slightly soluble in ether R.Category: Antigout drug.Storage: Colchicine should be kept in a tightly closed container, protected from light.Additional information: Colchicine is an alkaloid obtained from Colchicum autumnale L. (Fam. Liliaceae). It darkens on exposureto light. CAUTION: Colchicine is extremely poisonous and must be handled with care.

LACTMED

Colchicine

Created by admin on Fri Dec 15 17:19:07 UTC 2023 , Edited by admin on Fri Dec 15 17:19:07 UTC 2023

PRIMARY

MERCK INDEX

m3725

Created by admin on Fri Dec 15 17:19:07 UTC 2023 , Edited by admin on Fri Dec 15 17:19:07 UTC 2023

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Merck Index

FDA UNII

SML2Y3J35T

Created by admin on Fri Dec 15 17:19:07 UTC 2023 , Edited by admin on Fri Dec 15 17:19:07 UTC 2023

PRIMARY

MESH

D003078

Created by admin on Fri Dec 15 17:19:07 UTC 2023 , Edited by admin on Fri Dec 15 17:19:07 UTC 2023

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ChEMBL

CHEMBL107

Created by admin on Fri Dec 15 17:19:06 UTC 2023 , Edited by admin on Fri Dec 15 17:19:06 UTC 2023

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PUBCHEM

6167

Created by admin on Fri Dec 15 17:19:07 UTC 2023 , Edited by admin on Fri Dec 15 17:19:07 UTC 2023

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NDF-RT

N0000000239

Created by admin on Fri Dec 15 17:19:07 UTC 2023 , Edited by admin on Fri Dec 15 17:19:07 UTC 2023

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P-Glycoprotein Interactions [MoA]

NDF-RT

N0000182141

Created by admin on Fri Dec 15 17:19:07 UTC 2023 , Edited by admin on Fri Dec 15 17:19:07 UTC 2023

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Cytochrome P450 3A4 Inhibitors [MoA]

DAILYMED

SML2Y3J35T

Created by admin on Fri Dec 15 17:19:06 UTC 2023 , Edited by admin on Fri Dec 15 17:19:06 UTC 2023

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CAS

64-86-8

Created by admin on Fri Dec 15 17:19:06 UTC 2023 , Edited by admin on Fri Dec 15 17:19:06 UTC 2023

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NCI_THESAURUS

C385

Created by admin on Fri Dec 15 17:19:07 UTC 2023 , Edited by admin on Fri Dec 15 17:19:07 UTC 2023

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CHEBI

27882

Created by admin on Fri Dec 15 17:19:06 UTC 2023 , Edited by admin on Fri Dec 15 17:19:06 UTC 2023

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EPA CompTox

DTXSID5024845

Created by admin on Fri Dec 15 17:19:07 UTC 2023 , Edited by admin on Fri Dec 15 17:19:07 UTC 2023

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DRUG CENTRAL

726

Created by admin on Fri Dec 15 17:19:06 UTC 2023 , Edited by admin on Fri Dec 15 17:19:06 UTC 2023

PRIMARY

IUPHAR

2367

Created by admin on Fri Dec 15 17:19:07 UTC 2023 , Edited by admin on Fri Dec 15 17:19:07 UTC 2023

PRIMARY

NSC

757

Created by admin on Fri Dec 15 17:19:07 UTC 2023 , Edited by admin on Fri Dec 15 17:19:07 UTC 2023

PRIMARY

RS_ITEM_NUM

1146006

Created by admin on Fri Dec 15 17:19:07 UTC 2023 , Edited by admin on Fri Dec 15 17:19:07 UTC 2023

PRIMARY

RXCUI

2683

Created by admin on Fri Dec 15 17:19:07 UTC 2023 , Edited by admin on Fri Dec 15 17:19:07 UTC 2023

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RxNorm

WIKIPEDIA

COLCHICINE

Created by admin on Fri Dec 15 17:19:07 UTC 2023 , Edited by admin on Fri Dec 15 17:19:07 UTC 2023

PRIMARY

EVMPD

SUB01420MIG

Created by admin on Fri Dec 15 17:19:06 UTC 2023 , Edited by admin on Fri Dec 15 17:19:06 UTC 2023

PRIMARY

SMS_ID

100000090556

Created by admin on Fri Dec 15 17:19:07 UTC 2023 , Edited by admin on Fri Dec 15 17:19:07 UTC 2023

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DRUG BANK

DB01394

Created by admin on Fri Dec 15 17:19:06 UTC 2023 , Edited by admin on Fri Dec 15 17:19:06 UTC 2023

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Related Record Type Details


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					22ES734693

MULTIDRUG RESISTANCE PROTEIN 1

TRANSPORTER -> SUBSTRATE


					74UG0EWZ60

TUBULIN BETA CHAIN

TARGET->INHIBITOR OF AGGREGATION

Comments:

DESTABILIZES TUBULIN POLYMERS

Amount:


					96U5LG549X

MIVOBULIN

DERIVATIVE -> PARENT

Amount:


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE

Qualification:

APICAL

Amount:


					I59XKK41WY

COLCHICINE SALICYLATE

SALT/SOLVATE -> PARENT

Amount:

Related Record Type Details


					V9U19L3N0J

2-DEMETHYLCOLCHICINE

METABOLITE LESS ACTIVE -> PARENT

Qualification:

URINE

Amount:


					C939KS8QEL

3-DESMETHYLCOLCHICINE

METABOLITE LESS ACTIVE -> PARENT

Qualification:

URINE

Amount:

Related Record Type Details


					DYD0I854K7

COLCHICOSIDE

IMPURITY -> PARENT

Amount:


					7JX9WZ3SJ5

Colchicine conformational isomer

IMPURITY -> PARENT

Amount:


					U02803H7OJ

GLORIOSINE

IMPURITY -> PARENT

Amount:


					HJ30158L57

COLCHICEINE

IMPURITY -> PARENT

Amount:


					C939KS8QEL

3-DESMETHYLCOLCHICINE

IMPURITY -> PARENT

Amount:

Related Record Type Details


					SML2Y3J35T

Colchicine

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC