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Details

Stereochemistry ACHIRAL
Molecular Formula C23H28ClN3O5S
Molecular Weight 494.004
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GLYBURIDE

SMILES

COC1=C(C=C(Cl)C=C1)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3

InChI

InChIKey=ZNNLBTZKUZBEKO-UHFFFAOYSA-N
InChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29)

HIDE SMILES / InChI
Molecular Formula C23H28ClN3O5S
Molecular Weight 494.004
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:05:50 UTC 2023
Edited
by admin
on Fri Dec 15 15:05:50 UTC 2023
Record UNII
SX6K58TVWC
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GLYBURIDE
MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF   WHO-IP  
USAN  
Official Name English
U-26452
Code English
CIRARA
Brand Name English
HB-419
Code English
GLIBENCLAMIDE [EP MONOGRAPH]
Common Name English
GLYBURIDE [WHO-IP]
Common Name English
GLYBURIDE [MI]
Common Name English
GLYBENCLAMIDE
Common Name English
U-26,45
Code English
GLYBURIDE [USP MONOGRAPH]
Common Name English
GLUCOVANCE COMPONENT GLYBURIDE
Common Name English
GLYBURIDE COMPONENT OF GLUCOVANCE
Common Name English
MICRONASE
Brand Name English
HB 419
Code English
GLYBURIDE [USAN]
Common Name English
NSC-759618
Code English
GLIBENCLAMIDUM [WHO-IP LATIN]
Common Name English
GLIBENCLAMIDE
EP   INN   MART.   WHO-DD   WHO-IP  
INN  
Official Name English
GLYBURIDE [VANDF]
Common Name English
BENZAMIDE, 5-CHLORO-N-(2-(4-((((CYCLOHEXYLAMINO)CARBONYL)AMINO)SULFONYL)PHENYL)ETHYL)-2-METHOXY-
Systematic Name English
GLIBENCLAMIDE [MART.]
Common Name English
GLIBENCLAMIDE [WHO-IP]
Common Name English
U-26,452
Code English
GLYBURIDE [USP-RS]
Common Name English
glibenclamide [INN]
Common Name English
Glibenclamide [WHO-DD]
Common Name English
GLYNASE
Brand Name English
GLIBENCLAMIDE [JAN]
Common Name English
DIABETA
Brand Name English
1-((P-(2-(5-CHLORO-O-ANISAMIDO)ETHYL)PHENYL)SULFONYL)-3-CYCLOHEXYLUREA
Common Name English
GLYBURIDE [ORANGE BOOK]
Common Name English
Classification Tree Code System Code
NDF-RT N0000008054
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
NDF-RT N0000008054
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
FDA ORPHAN DRUG 502615
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
FDA ORPHAN DRUG 518816
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
LIVERTOX 463
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
WHO-VATC QA10BB01
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
NDF-RT N0000175608
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
FDA ORPHAN DRUG 539316
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
NDF-RT N0000008054
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
FDA ORPHAN DRUG 491215
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
WHO-ESSENTIAL MEDICINES LIST 18.5
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
EU-Orphan Drug EU/3/15/1589
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
NCI_THESAURUS C97936
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
WHO-ATC A10BB01
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
Code System Code Type Description
EVMPD
SUB07916MIG
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
PRIMARY
INN
2386
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
GLYBURIDE
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
PRIMARY Description: A white or almost white, crystalline powder; odourless or almost odourless. Solubility: Practically insoluble in water and ether R; slightly soluble in ethanol (~750 g/l) TS and methanol R. Category: Antidiabetic agent. Storage: Glibenclamide should be kept in a well-closed container. Definition: Glibenclamide contains not less than 98.5% and not more than 101.0% of C23H28ClN3O5S, calculated with reference to the dried substance.
DRUG CENTRAL
1314
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
PRIMARY
NSC
759618
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
PRIMARY
MERCK INDEX
m5784
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
PRIMARY Merck Index
DAILYMED
SX6K58TVWC
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
PRIMARY
CHEBI
5441
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
PRIMARY
LACTMED
Glyburide
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
PRIMARY
PUBCHEM
3488
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
PRIMARY
CAS
10238-21-8
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
PRIMARY
FDA UNII
SX6K58TVWC
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
PRIMARY
ECHA (EC/EINECS)
233-570-6
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
PRIMARY
SMS_ID
100000080403
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
PRIMARY
MESH
D005905
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
PRIMARY
RS_ITEM_NUM
1295505
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
PRIMARY
IUPHAR
2414
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
PRIMARY
WIKIPEDIA
GLIBENCLAMIDE
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
PRIMARY
DRUG BANK
DB01016
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
PRIMARY
RXCUI
4815
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
PRIMARY RxNorm
EPA CompTox
DTXSID0037237
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
PRIMARY
NCI_THESAURUS
C29076
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
PRIMARY
ChEMBL
CHEMBL472
Created by admin on Fri Dec 15 15:05:50 UTC 2023 , Edited by admin on Fri Dec 15 15:05:50 UTC 2023
PRIMARY
Related Record Type Details
OCT-1
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Structure of 4-(2-(5-CHLORO-2-METHOXYBENZAMIDO)ETHYL)PHENYLSULFONAMIDE
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Structure of GLYBURIDE
BASIS OF STRENGTH->SUBSTANCE
ASSAY (HPLC)
USP
ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8
TARGET -> INHIBITOR
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OATP1B1
TRANSPORTER -> INHIBITOR
BSEP
TRANSPORTER -> INHIBITOR
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1/400 as active as the parent in rat
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METABOLITE -> PARENT
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Structure of 3-HYDROXYGLYBURIDE, CIS-
METABOLITE -> PARENT
Structure of 4-HYDROXYGLYBURIDE, TRANS-
METABOLITE -> PARENT
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IMPURITY -> PARENT
Related Record Type Details
Structure of GLYBURIDE
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC
NIH
NCATS
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DISCLAIMER
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