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Details

Stereochemistry ACHIRAL
Molecular Formula C23H17FN6O
Molecular Weight 412.4191
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CAPMATINIB

SMILES

CNC(=O)C1=CC=C(C=C1F)C2=NN3C(CC4=CC=C5N=CC=CC5=C4)=CN=C3N=C2

InChI

InChIKey=LIOLIMKSCNQPLV-UHFFFAOYSA-N
InChI=1S/C23H17FN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31)

HIDE SMILES / InChI
Molecular Formula C23H17FN6O
Molecular Weight 412.4191
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Sat Dec 16 17:07:57 UTC 2023
Edited
by admin
on Sat Dec 16 17:07:57 UTC 2023
Record UNII
TY34L4F9OZ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CAPMATINIB
INN   USAN   WHO-DD  
USAN   INN  
Official Name English
CAPMATINIB [USAN]
Common Name English
INCB-28060 FREE BASE
Code English
INC280
Code English
NVP-INC280
Code English
INC-280
Code English
Capmatinib [WHO-DD]
Common Name English
capmatinib [INN]
Common Name English
CAPMATINIB [MI]
Common Name English
INCB-28060
Code English
2-FLUORO-N-METHYL-4-(7-(QUINOLIN-6-YLMETHYL)IMIDAZO(1,2-B)(1,2,4)TRIAZIN-2-YL)BENZAMIDE
Systematic Name English
BENZAMIDE, 2-FLUORO-N-METHYL-4-(7-(6-QUINOLINYLMETHYL)IMIDAZO(1,2-B)(1,2,4)TRIAZIN-2-YL)-
Systematic Name English
NVP-INC280-NX
Code English
Classification Tree Code System Code
NCI_THESAURUS C129825
Created by admin on Sat Dec 16 17:08:00 UTC 2023 , Edited by admin on Sat Dec 16 17:08:00 UTC 2023
FDA ORPHAN DRUG 644518
Created by admin on Sat Dec 16 17:08:00 UTC 2023 , Edited by admin on Sat Dec 16 17:08:00 UTC 2023
NCI_THESAURUS C1967
Created by admin on Sat Dec 16 17:08:00 UTC 2023 , Edited by admin on Sat Dec 16 17:08:00 UTC 2023
NCI_THESAURUS C1742
Created by admin on Sat Dec 16 17:08:00 UTC 2023 , Edited by admin on Sat Dec 16 17:08:00 UTC 2023
Code System Code Type Description
NCI_THESAURUS
C90564
Created by admin on Sat Dec 16 17:08:00 UTC 2023 , Edited by admin on Sat Dec 16 17:08:00 UTC 2023
PRIMARY
CAS
1029712-80-8
Created by admin on Sat Dec 16 17:08:00 UTC 2023 , Edited by admin on Sat Dec 16 17:08:00 UTC 2023
PRIMARY
SMS_ID
100000166975
Created by admin on Sat Dec 16 17:08:00 UTC 2023 , Edited by admin on Sat Dec 16 17:08:00 UTC 2023
PRIMARY
FDA UNII
TY34L4F9OZ
Created by admin on Sat Dec 16 17:08:00 UTC 2023 , Edited by admin on Sat Dec 16 17:08:00 UTC 2023
PRIMARY
WIKIPEDIA
Capmatinib
Created by admin on Sat Dec 16 17:08:00 UTC 2023 , Edited by admin on Sat Dec 16 17:08:00 UTC 2023
PRIMARY
MERCK INDEX
m12204
Created by admin on Sat Dec 16 17:08:00 UTC 2023 , Edited by admin on Sat Dec 16 17:08:00 UTC 2023
PRIMARY
EPA CompTox
DTXSID90145595
Created by admin on Sat Dec 16 17:08:00 UTC 2023 , Edited by admin on Sat Dec 16 17:08:00 UTC 2023
PRIMARY
EVMPD
SUB181273
Created by admin on Sat Dec 16 17:08:00 UTC 2023 , Edited by admin on Sat Dec 16 17:08:00 UTC 2023
PRIMARY
PUBCHEM
25145656
Created by admin on Sat Dec 16 17:08:00 UTC 2023 , Edited by admin on Sat Dec 16 17:08:00 UTC 2023
PRIMARY
RXCUI
2362165
Created by admin on Sat Dec 16 17:08:00 UTC 2023 , Edited by admin on Sat Dec 16 17:08:00 UTC 2023
PRIMARY
DAILYMED
TY34L4F9OZ
Created by admin on Sat Dec 16 17:08:00 UTC 2023 , Edited by admin on Sat Dec 16 17:08:00 UTC 2023
PRIMARY
USAN
EF-10
Created by admin on Sat Dec 16 17:08:00 UTC 2023 , Edited by admin on Sat Dec 16 17:08:00 UTC 2023
PRIMARY
ChEMBL
CHEMBL3188267
Created by admin on Sat Dec 16 17:08:00 UTC 2023 , Edited by admin on Sat Dec 16 17:08:00 UTC 2023
PRIMARY
INN
9948
Created by admin on Sat Dec 16 17:08:00 UTC 2023 , Edited by admin on Sat Dec 16 17:08:00 UTC 2023
PRIMARY
DRUG BANK
DB11791
Created by admin on Sat Dec 16 17:08:00 UTC 2023 , Edited by admin on Sat Dec 16 17:08:00 UTC 2023
PRIMARY
Related Record Type Details
MULTIDRUG AND TOXIN EXTRUSION PROTEIN 2-K
TRANSPORTER -> INHIBITOR
REVERSIBLE
Structure of CAPMATINIB
EXCRETED UNCHANGED
AMOUNT EXCRETED
FECAL
MULTIDRUG AND TOXIN EXTRUSION PROTEIN 1
TRANSPORTER -> INHIBITOR
REVERSIBLE
HEPATOCYTE GROWTH FACTOR RECEPTOR
TARGET -> INHIBITOR
Structure of CAPMATINIB
EXCRETED UNCHANGED
TRACE AMOUNT
URINE
MULTIDRUG RESISTANCE PROTEIN 1
TRANSPORTER -> SUBSTRATE
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
independent of capmatinib concentration
BINDING
Structure of CAPMATINIB HYDROCHLORIDE
SALT/SOLVATE -> PARENT
CYTOCHROME P450 3A4
METABOLIC ENZYME -> SUBSTRATE
Structure of CAPMATINIB HYDROCHLORIDE ANHYDROUS
SALT/SOLVATE -> PARENT
ALDEHYDE OXIDASE
METABOLIC ENZYME -> SUBSTRATE
Related Record Type Details
Structure of CMN-290
METABOLITE -> PARENT
PLASMA
Structure of CNJ-294
METABOLITE -> PARENT
URINE
Structure of CJH-800
METABOLITE -> PARENT
FECAL; PLASMA; URINE
Structure of CMN-288
METABOLITE -> PARENT
URINE
Structure of CJK-530
METABOLITE -> PARENT
FECAL; PLASMA; URINE
Structure of CMC-583
METABOLITE -> PARENT
PLASMA
Structure of CMN-288
METABOLITE -> PARENT
FECAL
Structure of CMC-583
METABOLITE -> PARENT
MINOR
FECAL; URINE
Structure of CMN-288
METABOLITE -> PARENT
MAJOR
PLASMA
Structure of CNJ-294
METABOLITE -> PARENT
PLASMA
Structure of CNN-019
METABOLITE -> PARENT
Structure of CMN-290
METABOLITE -> PARENT
MINOR
FECAL; URINE
Related Record Type Details
Structure of CAPMATINIB
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Tmax PHARMACOKINETIC IN PATIENTS WITH CANCER

ORAL ADMINISTRATION

blood-to-plasma ratio PHARMACOKINETIC at higher concentrations

blood-to-plasma ratio PHARMACOKINETIC
Biological Half-life PHARMACOKINETIC
Volume of Distribution PHARMACOKINETIC AT STEADY-STATE

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