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Details

Stereochemistry ABSOLUTE
Molecular Formula C22H22F3N
Molecular Weight 357.412
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CINACALCET

SMILES

C[C@@H](NCCCC1=CC(=CC=C1)C(F)(F)F)C2=CC=CC3=CC=CC=C23

InChI

InChIKey=VDHAWDNDOKGFTD-MRXNPFEDSA-N
InChI=1S/C22H22F3N/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3/t16-/m1/s1

HIDE SMILES / InChI
Molecular Formula C22H22F3N
Molecular Weight 357.412
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:45:21 UTC 2023
Edited
by admin
on Fri Dec 15 15:45:21 UTC 2023
Record UNII
UAZ6V7728S
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CINACALCET
EMA EPAR   HSDB   INN   MI   USAN   VANDF   WHO-DD  
USAN   INN  
Official Name English
AMG-073
Code English
Cinacalcet [WHO-DD]
Common Name English
CINACALCET [HSDB]
Common Name English
1-NAPHTHALENEMETHANAMINE, .ALPHA.-METHYL-N-(3-(3-(TRIFLUOROMETHYL)PHENYL)PROPYL)-, (.ALPHA.R)-
Common Name English
CINACALCET [EMA EPAR]
Common Name English
KRN1493
Code English
CINACALCET [MI]
Common Name English
AMG073
Code English
CINACALCET [USAN]
Common Name English
N-[(1R)-1-(Naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine
Systematic Name English
CINACALCET [VANDF]
Common Name English
AMG 073
Code English
KRN-1493
Code English
cinacalcet [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C2136
Created by admin on Fri Dec 15 15:45:21 UTC 2023 , Edited by admin on Fri Dec 15 15:45:21 UTC 2023
WHO-VATC QH05BX01
Created by admin on Fri Dec 15 15:45:21 UTC 2023 , Edited by admin on Fri Dec 15 15:45:21 UTC 2023
WHO-ATC H05BX01
Created by admin on Fri Dec 15 15:45:21 UTC 2023 , Edited by admin on Fri Dec 15 15:45:21 UTC 2023
NDF-RT N0000020081
Created by admin on Fri Dec 15 15:45:21 UTC 2023 , Edited by admin on Fri Dec 15 15:45:21 UTC 2023
NDF-RT N0000175902
Created by admin on Fri Dec 15 15:45:21 UTC 2023 , Edited by admin on Fri Dec 15 15:45:21 UTC 2023
FDA ORPHAN DRUG 163402
Created by admin on Fri Dec 15 15:45:21 UTC 2023 , Edited by admin on Fri Dec 15 15:45:21 UTC 2023
EMA ASSESSMENT REPORTS MIMPARA (AUTHORIZED: HYPERPARATHYROIDISM, PARATHYROID NEOPLASMS, HYPERCALCEMIA)
Created by admin on Fri Dec 15 15:45:21 UTC 2023 , Edited by admin on Fri Dec 15 15:45:21 UTC 2023
FDA ORPHAN DRUG 165102
Created by admin on Fri Dec 15 15:45:21 UTC 2023 , Edited by admin on Fri Dec 15 15:45:21 UTC 2023
FDA ORPHAN DRUG 511315
Created by admin on Fri Dec 15 15:45:21 UTC 2023 , Edited by admin on Fri Dec 15 15:45:21 UTC 2023
EMA ASSESSMENT REPORTS PARAREG (WITHDRAWN: HYPERPARATHYROIDISM, PARATHYROID NEOPLASMS, HYPERCALCEMIA)
Created by admin on Fri Dec 15 15:45:21 UTC 2023 , Edited by admin on Fri Dec 15 15:45:21 UTC 2023
Code System Code Type Description
INN
8287
Created by admin on Fri Dec 15 15:45:21 UTC 2023 , Edited by admin on Fri Dec 15 15:45:21 UTC 2023
PRIMARY
EPA CompTox
DTXSID8048286
Created by admin on Fri Dec 15 15:45:21 UTC 2023 , Edited by admin on Fri Dec 15 15:45:21 UTC 2023
PRIMARY
CHEBI
48390
Created by admin on Fri Dec 15 15:45:21 UTC 2023 , Edited by admin on Fri Dec 15 15:45:21 UTC 2023
PRIMARY
MESH
C476217
Created by admin on Fri Dec 15 15:45:21 UTC 2023 , Edited by admin on Fri Dec 15 15:45:21 UTC 2023
PRIMARY
SMS_ID
100000089455
Created by admin on Fri Dec 15 15:45:21 UTC 2023 , Edited by admin on Fri Dec 15 15:45:21 UTC 2023
PRIMARY
DAILYMED
UAZ6V7728S
Created by admin on Fri Dec 15 15:45:21 UTC 2023 , Edited by admin on Fri Dec 15 15:45:21 UTC 2023
PRIMARY
PUBCHEM
156419
Created by admin on Fri Dec 15 15:45:21 UTC 2023 , Edited by admin on Fri Dec 15 15:45:21 UTC 2023
PRIMARY
WIKIPEDIA
Cinacalcet
Created by admin on Fri Dec 15 15:45:21 UTC 2023 , Edited by admin on Fri Dec 15 15:45:21 UTC 2023
PRIMARY
USAN
QQ-71
Created by admin on Fri Dec 15 15:45:21 UTC 2023 , Edited by admin on Fri Dec 15 15:45:21 UTC 2023
PRIMARY
NCI_THESAURUS
C74100
Created by admin on Fri Dec 15 15:45:21 UTC 2023 , Edited by admin on Fri Dec 15 15:45:21 UTC 2023
PRIMARY
EVMPD
SUB25416
Created by admin on Fri Dec 15 15:45:21 UTC 2023 , Edited by admin on Fri Dec 15 15:45:21 UTC 2023
PRIMARY
HSDB
7318
Created by admin on Fri Dec 15 15:45:21 UTC 2023 , Edited by admin on Fri Dec 15 15:45:21 UTC 2023
PRIMARY
ChEMBL
CHEMBL1201284
Created by admin on Fri Dec 15 15:45:21 UTC 2023 , Edited by admin on Fri Dec 15 15:45:21 UTC 2023
PRIMARY
IUPHAR
3308
Created by admin on Fri Dec 15 15:45:21 UTC 2023 , Edited by admin on Fri Dec 15 15:45:21 UTC 2023
PRIMARY
RXCUI
407990
Created by admin on Fri Dec 15 15:45:21 UTC 2023 , Edited by admin on Fri Dec 15 15:45:21 UTC 2023
PRIMARY RxNorm
DRUG CENTRAL
647
Created by admin on Fri Dec 15 15:45:21 UTC 2023 , Edited by admin on Fri Dec 15 15:45:21 UTC 2023
PRIMARY
MERCK INDEX
m3555
Created by admin on Fri Dec 15 15:45:21 UTC 2023 , Edited by admin on Fri Dec 15 15:45:21 UTC 2023
PRIMARY Merck Index
FDA UNII
UAZ6V7728S
Created by admin on Fri Dec 15 15:45:21 UTC 2023 , Edited by admin on Fri Dec 15 15:45:21 UTC 2023
PRIMARY
CAS
226256-56-0
Created by admin on Fri Dec 15 15:45:21 UTC 2023 , Edited by admin on Fri Dec 15 15:45:21 UTC 2023
PRIMARY
DRUG BANK
DB01012
Created by admin on Fri Dec 15 15:45:21 UTC 2023 , Edited by admin on Fri Dec 15 15:45:21 UTC 2023
PRIMARY
Related Record Type Details
Structure of CINACALCET HYDROCHLORIDE
SALT/SOLVATE -> PARENT
CYTOCHROME P450 2D6
METABOLIC ENZYME -> SUBSTRATE
MAJOR
EXTRACELLULAR CALCIUM-SENSING RECEPTOR
TARGET -> AGONIST
CYTOCHROME P450 1A2
METABOLIC ENZYME -> SUBSTRATE
MAJOR
CYTOCHROME P450 3A4
METABOLIC ENZYME -> SUBSTRATE
MAJOR
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
Related Record Type Details
Structure of M-(TRIFLUOROMETHYL)CINNAMIC ACID
METABOLITE -> PARENT
Structure of M-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID
METABOLITE -> PARENT
Structure of 1,2-DIHYDRO-2-HYDROXY-4-((1R)-1-((3-(3-(TRIFLUOROMETHYL)PHENYL)PROPYL)AMINO)ETHYL)-1-NAPHTHALENYL-.BETA.-D-GLUCOPYRANOSIDURONIC ACID, (1R,2R)-
METABOLITE -> PARENT
Structure of M-TRIFLUOROMETHYLHIPPURIC ACID
METABOLITE -> PARENT
Structure of GLYCINYL M-(TRIFLUOROMETHYL)CINNAMATE
METABOLITE -> PARENT
Structure of 3-(TRIFLUOROMETHYL)BENZOIC ACID
METABOLITE -> PARENT
Structure of 3-HYDROXY-3-(3-(TRIFLUOROMETHYL)PHENYL)PROPANOIC ACID
METABOLITE -> PARENT
MINOR
Related Record Type Details
Structure of CINACALCET
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Volume of Distribution PHARMACOKINETIC
Tmax PHARMACOKINETIC ORAL ADMINISTRATION

Biological Half-life PHARMACOKINETIC
NIH
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