VARDENAFIL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H32N6O4S
Molecular Weight	488.603
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCC1=NC(C)=C2N1NC(=NC2=O)C3=CC(=CC=C3OCC)S(=O)(=O)N4CCN(CC)CC4

InChI

InChIKey=SECKRCOLJRRGGV-UHFFFAOYSA-N

InChI=1S/C23H32N6O4S/c1-5-8-20-24-16(4)21-23(30)25-22(26-29(20)21)18-15-17(9-10-19(18)33-7-3)34(31,32)28-13-11-27(6-2)12-14-28/h9-10,15H,5-8,11-14H2,1-4H3,(H,25,26,30)

HIDE SMILES / InChI

Molecular Formula	C23H32N6O4S
Molecular Weight	488.603
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:44:26 UTC 2023` Edited by `admin` on `Fri Dec 15 15:44:26 UTC 2023`
Record UNII	UCE6F4125H
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

VARDENAFIL

Official Name

English

VARDENAFIL [USAN]

Common Name

English

VARDENAFIL [EMA EPAR]

Common Name

English

VARDENAFIL [VANDF]

Common Name

English

VARDENAFIL [HSDB]

Common Name

English

vardenafil [INN]

Common Name

English

Vardenafil [WHO-DD]

Common Name

English

VARDENAFIL [MART.]

Common Name

English

1-((3-(3,4-DIHYDRO-5-METHYL-4-OXO-7-PROPYLIMIDAZO(5,1-F)-AS-TRIAZIN-2-YL)-4-ETHOXYPHENYL)SULFONYL)-4-ETHYLPIPERAZINE

Common Name

English

VIVANZA

Brand Name

English

BAY-389456

Code

English

VARDENAFIL [MI]

Common Name

English

BAY38-9456

Code

English

Classification Tree Code System Code

EMA ASSESSMENT REPORTS

LEVITRA (AUTHORIZED: ERECTILE DYSFUNCTIONS)

Created by admin on Fri Dec 15 15:44:27 UTC 2023 , Edited by admin on Fri Dec 15 15:44:27 UTC 2023

NDF-RT

N0000020026

Created by admin on Fri Dec 15 15:44:27 UTC 2023 , Edited by admin on Fri Dec 15 15:44:27 UTC 2023

FDA ORPHAN DRUG

679319

Created by admin on Fri Dec 15 15:44:27 UTC 2023 , Edited by admin on Fri Dec 15 15:44:27 UTC 2023

WHO-ATC

G04BE09

Created by admin on Fri Dec 15 15:44:27 UTC 2023 , Edited by admin on Fri Dec 15 15:44:27 UTC 2023

WHO-VATC

QG04BE09

Created by admin on Fri Dec 15 15:44:27 UTC 2023 , Edited by admin on Fri Dec 15 15:44:27 UTC 2023

LIVERTOX

NBK548920

Created by admin on Fri Dec 15 15:44:27 UTC 2023 , Edited by admin on Fri Dec 15 15:44:27 UTC 2023

NCI_THESAURUS

C2127

Created by admin on Fri Dec 15 15:44:27 UTC 2023 , Edited by admin on Fri Dec 15 15:44:27 UTC 2023

NDF-RT

N0000175599

Created by admin on Fri Dec 15 15:44:27 UTC 2023 , Edited by admin on Fri Dec 15 15:44:27 UTC 2023

EMA ASSESSMENT REPORTS

VIVANZA (AUTHORIZED: ERECTILE DYSFUNCTIONS)

Created by admin on Fri Dec 15 15:44:27 UTC 2023 , Edited by admin on Fri Dec 15 15:44:27 UTC 2023

Code System Code Type Description

DAILYMED

UCE6F4125H

Created by admin on Fri Dec 15 15:44:27 UTC 2023 , Edited by admin on Fri Dec 15 15:44:27 UTC 2023

PRIMARY

INN

7950

Created by admin on Fri Dec 15 15:44:27 UTC 2023 , Edited by admin on Fri Dec 15 15:44:27 UTC 2023

PRIMARY

MESH

C426063

Created by admin on Fri Dec 15 15:44:27 UTC 2023 , Edited by admin on Fri Dec 15 15:44:27 UTC 2023

PRIMARY

USAN

NN-53

Created by admin on Fri Dec 15 15:44:27 UTC 2023 , Edited by admin on Fri Dec 15 15:44:27 UTC 2023

PRIMARY

WIKIPEDIA

VARDENAFIL

Created by admin on Fri Dec 15 15:44:27 UTC 2023 , Edited by admin on Fri Dec 15 15:44:27 UTC 2023

PRIMARY

SMS_ID

100000089525

Created by admin on Fri Dec 15 15:44:27 UTC 2023 , Edited by admin on Fri Dec 15 15:44:27 UTC 2023

PRIMARY

NCI_THESAURUS

C66650

Created by admin on Fri Dec 15 15:44:27 UTC 2023 , Edited by admin on Fri Dec 15 15:44:27 UTC 2023

PRIMARY

HSDB

7304

Created by admin on Fri Dec 15 15:44:27 UTC 2023 , Edited by admin on Fri Dec 15 15:44:27 UTC 2023

PRIMARY

IUPHAR

7320

Created by admin on Fri Dec 15 15:44:27 UTC 2023 , Edited by admin on Fri Dec 15 15:44:27 UTC 2023

PRIMARY

LACTMED

Vardenafil

Created by admin on Fri Dec 15 15:44:27 UTC 2023 , Edited by admin on Fri Dec 15 15:44:27 UTC 2023

PRIMARY

RXCUI

306674

Created by admin on Fri Dec 15 15:44:27 UTC 2023 , Edited by admin on Fri Dec 15 15:44:27 UTC 2023

PRIMARY

RxNorm

PUBCHEM

135400189

Created by admin on Fri Dec 15 15:44:27 UTC 2023 , Edited by admin on Fri Dec 15 15:44:27 UTC 2023

PRIMARY

EPA CompTox

DTXSID3048318

Created by admin on Fri Dec 15 15:44:27 UTC 2023 , Edited by admin on Fri Dec 15 15:44:27 UTC 2023

PRIMARY

ChEMBL

CHEMBL1520

Created by admin on Fri Dec 15 15:44:27 UTC 2023 , Edited by admin on Fri Dec 15 15:44:27 UTC 2023

PRIMARY

CAS

224785-90-4

Created by admin on Fri Dec 15 15:44:26 UTC 2023 , Edited by admin on Fri Dec 15 15:44:26 UTC 2023

PRIMARY

DRUG BANK

DB00862

Created by admin on Fri Dec 15 15:44:27 UTC 2023 , Edited by admin on Fri Dec 15 15:44:27 UTC 2023

PRIMARY

FDA UNII

UCE6F4125H

Created by admin on Fri Dec 15 15:44:27 UTC 2023 , Edited by admin on Fri Dec 15 15:44:27 UTC 2023

PRIMARY

DRUG CENTRAL

2809

Created by admin on Fri Dec 15 15:44:27 UTC 2023 , Edited by admin on Fri Dec 15 15:44:27 UTC 2023

PRIMARY

MERCK INDEX

m11394

Created by admin on Fri Dec 15 15:44:27 UTC 2023 , Edited by admin on Fri Dec 15 15:44:27 UTC 2023

PRIMARY

Merck Index

EVMPD

SUB20047

Created by admin on Fri Dec 15 15:44:27 UTC 2023 , Edited by admin on Fri Dec 15 15:44:27 UTC 2023

PRIMARY

Related Record Type Details


					805SU96HKF

CYTOCHROME P450 3A5

METABOLIC ENZYME -> SUBSTRATE


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					5M8S2CU0TS

VARDENAFIL HYDROCHLORIDE

SALT/SOLVATE -> PARENT


					5O8R96XMH7

VARDENAFIL DIHYDROCHLORIDE

SALT/SOLVATE -> PARENT


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE

Interaction Type:

MAJOR


					22ES734693

MULTIDRUG RESISTANCE PROTEIN 1

TRANSPORTER -> INHIBITOR

Amount:


					IF61NL91H3

VARDENAFIL HYDROCHLORIDE ANHYDROUS

SALT/SOLVATE -> PARENT

Related Record Type Details


					3DT5R783ZM

BENZENESULFONAMIDE, N-(2-AMINOETHYL)-3-(1,4-DIHYDRO-5-METHYL-4-OXO-7-PROPYLIMIDAZO(5,1-F)(1,2,4)TRIAZIN-2-YL)-4-ETHOXY-

METABOLITE -> PARENT

Qualification:

FECAL; PLASMA


					5W2L2F6HYQ

4-ETHOXY-N-(2-(ETHYLAMINO)ETHYL)-3-(5-METHYL-4-OXO-7-PROPYL-3H-IMIDAZO(5,1-F)(1,2,4)TRIAZIN-2-YL)BENZENESULFONAMIDE

METABOLITE -> PARENT

Comments:

CYP2C9 also contributes to the metabolism of vardenafil.

Interaction Type:

MINOR

Qualification:

FECAL; PLASMA; URINE

Related Record Type Details


					UCE6F4125H

VARDENAFIL

ACTIVE MOIETY

Name	Property Type	Parameters
Tmax	PHARMACOKINETIC	FASTED STATE

Volume of Distribution	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC