ZILEUTON

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C11H12N2O2S
Molecular Weight	236.29
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ZILEUTON

Structure Search

SMILES

CC(N(O)C(N)=O)C1=CC2=C(S1)C=CC=C2

InChI

InChIKey=MWLSOWXNZPKENC-UHFFFAOYSA-N

InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14)

HIDE SMILES / InChI

Molecular Formula	C11H12N2O2S
Molecular Weight	236.29
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:53:14 UTC 2023` Edited by `admin` on `Fri Dec 15 15:53:14 UTC 2023`
Record UNII	V1L22WVE2S
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ZILEUTON

Official Name

English

NSC-730712

Code

English

(±)-1-(1-BENZO(B)THIEN-2-YLETHYL)-1-HYDROXYUREA

Systematic Name

English

UREA, N-(1-BENZO(B)THIEN-2-YLETHYL)-N-HYDROXY-, (±)-

Systematic Name

English

ZILEUTON [USAN]

Common Name

English

NSC-759277

Code

English

ZILEUTON [USP-RS]

Common Name

English

zileuton [INN]

Common Name

English

ZILEUTON [MI]

Common Name

English

ZYFLO

Brand Name

English

A-64077

Code

English

ZILEUTON [USP MONOGRAPH]

Common Name

English

ABBOTT-64077

Code

English

ZILEUTON [ORANGE BOOK]

Common Name

English

ZILEUTON [MART.]

Common Name

English

Zileuton [WHO-DD]

Common Name

English

ZILEUTON [VANDF]

Common Name

English

Classification Tree Code System Code

NDF-RT

N0000008683

Created by admin on Fri Dec 15 15:53:14 UTC 2023 , Edited by admin on Fri Dec 15 15:53:14 UTC 2023

NDF-RT

N0000175956

Created by admin on Fri Dec 15 15:53:14 UTC 2023 , Edited by admin on Fri Dec 15 15:53:14 UTC 2023

LIVERTOX

NBK548397

Created by admin on Fri Dec 15 15:53:14 UTC 2023 , Edited by admin on Fri Dec 15 15:53:14 UTC 2023

NCI_THESAURUS

C1322

Created by admin on Fri Dec 15 15:53:14 UTC 2023 , Edited by admin on Fri Dec 15 15:53:14 UTC 2023

NDF-RT

N0000175955

Created by admin on Fri Dec 15 15:53:14 UTC 2023 , Edited by admin on Fri Dec 15 15:53:14 UTC 2023

NDF-RT

N0000008683

Created by admin on Fri Dec 15 15:53:14 UTC 2023 , Edited by admin on Fri Dec 15 15:53:14 UTC 2023

Code System Code Type Description

NSC

759277

Created by admin on Fri Dec 15 15:53:14 UTC 2023 , Edited by admin on Fri Dec 15 15:53:14 UTC 2023

PRIMARY

DRUG BANK

DB00744

Created by admin on Fri Dec 15 15:53:14 UTC 2023 , Edited by admin on Fri Dec 15 15:53:14 UTC 2023

PRIMARY

NSC

730712

Created by admin on Fri Dec 15 15:53:14 UTC 2023 , Edited by admin on Fri Dec 15 15:53:14 UTC 2023

PRIMARY

ChEMBL

CHEMBL93

Created by admin on Fri Dec 15 15:53:14 UTC 2023 , Edited by admin on Fri Dec 15 15:53:14 UTC 2023

PRIMARY

SMS_ID

100000079065

Created by admin on Fri Dec 15 15:53:14 UTC 2023 , Edited by admin on Fri Dec 15 15:53:14 UTC 2023

PRIMARY

CHEBI

10112

Created by admin on Fri Dec 15 15:53:14 UTC 2023 , Edited by admin on Fri Dec 15 15:53:14 UTC 2023

PRIMARY

USAN

AA-18

Created by admin on Fri Dec 15 15:53:14 UTC 2023 , Edited by admin on Fri Dec 15 15:53:14 UTC 2023

PRIMARY

CAS

111406-87-2

Created by admin on Fri Dec 15 15:53:14 UTC 2023 , Edited by admin on Fri Dec 15 15:53:14 UTC 2023

PRIMARY

INN

6595

Created by admin on Fri Dec 15 15:53:14 UTC 2023 , Edited by admin on Fri Dec 15 15:53:14 UTC 2023

PRIMARY

NCI_THESAURUS

C26667

Created by admin on Fri Dec 15 15:53:14 UTC 2023 , Edited by admin on Fri Dec 15 15:53:14 UTC 2023

PRIMARY

DAILYMED

V1L22WVE2S

Created by admin on Fri Dec 15 15:53:14 UTC 2023 , Edited by admin on Fri Dec 15 15:53:14 UTC 2023

PRIMARY

LACTMED

Zileuton

Created by admin on Fri Dec 15 15:53:14 UTC 2023 , Edited by admin on Fri Dec 15 15:53:14 UTC 2023

PRIMARY

MESH

C063449

Created by admin on Fri Dec 15 15:53:14 UTC 2023 , Edited by admin on Fri Dec 15 15:53:14 UTC 2023

PRIMARY

RS_ITEM_NUM

1724656

Created by admin on Fri Dec 15 15:53:14 UTC 2023 , Edited by admin on Fri Dec 15 15:53:14 UTC 2023

PRIMARY

WIKIPEDIA

ZILEUTON

Created by admin on Fri Dec 15 15:53:14 UTC 2023 , Edited by admin on Fri Dec 15 15:53:14 UTC 2023

PRIMARY

PUBCHEM

60490

Created by admin on Fri Dec 15 15:53:14 UTC 2023 , Edited by admin on Fri Dec 15 15:53:14 UTC 2023

PRIMARY

EVMPD

SUB00157MIG

Created by admin on Fri Dec 15 15:53:14 UTC 2023 , Edited by admin on Fri Dec 15 15:53:14 UTC 2023

PRIMARY

EPA CompTox

DTXSID9023752

Created by admin on Fri Dec 15 15:53:14 UTC 2023 , Edited by admin on Fri Dec 15 15:53:14 UTC 2023

PRIMARY

RXCUI

40575

Created by admin on Fri Dec 15 15:53:14 UTC 2023 , Edited by admin on Fri Dec 15 15:53:14 UTC 2023

PRIMARY

RxNorm

FDA UNII

V1L22WVE2S

Created by admin on Fri Dec 15 15:53:14 UTC 2023 , Edited by admin on Fri Dec 15 15:53:14 UTC 2023

PRIMARY

MERCK INDEX

m11593

Created by admin on Fri Dec 15 15:53:14 UTC 2023 , Edited by admin on Fri Dec 15 15:53:14 UTC 2023

PRIMARY

Merck Index

IUPHAR

5297

Created by admin on Fri Dec 15 15:53:14 UTC 2023 , Edited by admin on Fri Dec 15 15:53:14 UTC 2023

PRIMARY

DRUG CENTRAL

2862

Created by admin on Fri Dec 15 15:53:14 UTC 2023 , Edited by admin on Fri Dec 15 15:53:14 UTC 2023

PRIMARY

Related Record Type Details


					V1L22WVE2S

ZILEUTON

EXCRETED UNCHANGED

Qualification:

FECAL; URINE

Amount:


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE


					8POY3UMU73

ENANTIOMER -> RACEMATE


					0CG9649AC6

ENANTIOMER -> RACEMATE


					L9DP834D1P

CYTOCHROME P450 2C9

METABOLIC ENZYME -> SUBSTRATE


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					VK5307M28Q

ARACHIDONATE 5-LIPOXYGENASE

TARGET -> INHIBITOR


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					VK4SQL11C0

CYTOCHROME P450 1A2

METABOLIC ENZYME -> SUBSTRATE

Related Record Type Details


					N5BK7P9ENT

(S)-N-DEHYDROXYZILEUTON (R)-SULFOXIDE

METABOLITE -> PARENT

Interaction Type:

IN-VITRO

Amount:


					AA5Z9B64VD

(R)-N-DEHYDROXYZILEUTON (R)-SULFOXIDE

METABOLITE -> PARENT

Amount:


					38DF69S4KY

(S)-ZILEUTON (R)-SULFOXIDE

METABOLITE -> PARENT

Interaction Type:

IN-VITRO

Amount:


					LDE6PT2VKH

ZILEUTON N-GLUCURONIDE

METABOLITE -> PARENT

Related Record Type Details


					3U9B73C27C

METHANONE, BIS(BENZO(B)THIEN-2-YL)-

IMPURITY -> PARENT

Related Record Type Details


					V1L22WVE2S

ZILEUTON

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC

Route of Elimination	PHARMACOKINETIC

Tmax	PHARMACOKINETIC				ORAL ADMINISTRATION

Volume of Distribution	PHARMACOKINETIC

Tmax	PHARMACOKINETIC				ORAL ADMINISTRATION FED CONDITION

Route of Elimination	PHARMACOKINETIC