VARENICLINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H13N3
Molecular Weight	211.2624
Optical Activity	NONE
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of VARENICLINE

Structure Search

SMILES

C1[C@H]2CNC[C@@H]1C3=CC4=C(C=C23)N=CC=N4

InChI

InChIKey=JQSHBVHOMNKWFT-DTORHVGOSA-N

InChI=1S/C13H13N3/c1-2-16-13-5-11-9-3-8(6-14-7-9)10(11)4-12(13)15-1/h1-2,4-5,8-9,14H,3,6-7H2/t8-,9+

HIDE SMILES / InChI

Molecular Formula	C13H13N3
Molecular Weight	211.2624
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:38:01 UTC 2023` Edited by `admin` on `Fri Dec 15 15:38:01 UTC 2023`
Record UNII	W6HS99O8ZO
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

VARENICLINE

Official Name

English

VARENICLINE [MI]

Common Name

English

CP-526,555

Code

English

VARENICLINE [EMA EPAR]

Common Name

English

VARENICLINE [HSDB]

Common Name

English

VARENICLINE [VANDF]

Common Name

English

VARENICLINE [MART.]

Common Name

English

CP-526555

Code

English

7,8,9,10-TETRAHYDRO-6H-6,10-METHANOAZEPINO(4,5-G)QUINOXALINE

Systematic Name

English

varenicline [INN]

Common Name

English

Varenicline [WHO-DD]

Common Name

English

Classification Tree Code System Code

NDF-RT

N0000175702

Created by admin on Fri Dec 15 15:38:01 UTC 2023 , Edited by admin on Fri Dec 15 15:38:01 UTC 2023

NDF-RT

N0000175702

Created by admin on Fri Dec 15 15:38:01 UTC 2023 , Edited by admin on Fri Dec 15 15:38:01 UTC 2023

NDF-RT

N0000175705

Created by admin on Fri Dec 15 15:38:01 UTC 2023 , Edited by admin on Fri Dec 15 15:38:01 UTC 2023

LIVERTOX

NBK548100

Created by admin on Fri Dec 15 15:38:01 UTC 2023 , Edited by admin on Fri Dec 15 15:38:01 UTC 2023

NDF-RT

N0000175702

Created by admin on Fri Dec 15 15:38:01 UTC 2023 , Edited by admin on Fri Dec 15 15:38:01 UTC 2023

EMA ASSESSMENT REPORTS

CHAMPIX (AUTHORIZED:TOBACCO USE CESSATION)

Created by admin on Fri Dec 15 15:38:01 UTC 2023 , Edited by admin on Fri Dec 15 15:38:01 UTC 2023

WHO-VATC

QN07BA03

Created by admin on Fri Dec 15 15:38:01 UTC 2023 , Edited by admin on Fri Dec 15 15:38:01 UTC 2023

WHO-ATC

N07BA03

Created by admin on Fri Dec 15 15:38:01 UTC 2023 , Edited by admin on Fri Dec 15 15:38:01 UTC 2023

NCI_THESAURUS

C73579

Created by admin on Fri Dec 15 15:38:01 UTC 2023 , Edited by admin on Fri Dec 15 15:38:01 UTC 2023

Code System Code Type Description

NCI_THESAURUS

C73609

Created by admin on Fri Dec 15 15:38:01 UTC 2023 , Edited by admin on Fri Dec 15 15:38:01 UTC 2023

PRIMARY

IUPHAR

5459

Created by admin on Fri Dec 15 15:38:01 UTC 2023 , Edited by admin on Fri Dec 15 15:38:01 UTC 2023

PRIMARY

FDA UNII

W6HS99O8ZO

Created by admin on Fri Dec 15 15:38:01 UTC 2023 , Edited by admin on Fri Dec 15 15:38:01 UTC 2023

PRIMARY

ChEMBL

CHEMBL1396

Created by admin on Fri Dec 15 15:38:01 UTC 2023 , Edited by admin on Fri Dec 15 15:38:01 UTC 2023

PRIMARY

DAILYMED

W6HS99O8ZO

Created by admin on Fri Dec 15 15:38:01 UTC 2023 , Edited by admin on Fri Dec 15 15:38:01 UTC 2023

PRIMARY

MESH

C500838

Created by admin on Fri Dec 15 15:38:01 UTC 2023 , Edited by admin on Fri Dec 15 15:38:01 UTC 2023

PRIMARY

SMS_ID

100000089154

Created by admin on Fri Dec 15 15:38:01 UTC 2023 , Edited by admin on Fri Dec 15 15:38:01 UTC 2023

PRIMARY

DRUG CENTRAL

2808

Created by admin on Fri Dec 15 15:38:01 UTC 2023 , Edited by admin on Fri Dec 15 15:38:01 UTC 2023

PRIMARY

EPA CompTox

DTXSID70891447

Created by admin on Fri Dec 15 15:38:01 UTC 2023 , Edited by admin on Fri Dec 15 15:38:01 UTC 2023

PRIMARY

CAS

249296-44-4

Created by admin on Fri Dec 15 15:38:01 UTC 2023 , Edited by admin on Fri Dec 15 15:38:01 UTC 2023

PRIMARY

LACTMED

Varenicline

Created by admin on Fri Dec 15 15:38:01 UTC 2023 , Edited by admin on Fri Dec 15 15:38:01 UTC 2023

PRIMARY

HSDB

7591

Created by admin on Fri Dec 15 15:38:01 UTC 2023 , Edited by admin on Fri Dec 15 15:38:01 UTC 2023

PRIMARY

MERCK INDEX

m11395

Created by admin on Fri Dec 15 15:38:01 UTC 2023 , Edited by admin on Fri Dec 15 15:38:01 UTC 2023

PRIMARY

Merck Index

RXCUI

591622

Created by admin on Fri Dec 15 15:38:01 UTC 2023 , Edited by admin on Fri Dec 15 15:38:01 UTC 2023

PRIMARY

RxNorm

EVMPD

SUB25195

Created by admin on Fri Dec 15 15:38:01 UTC 2023 , Edited by admin on Fri Dec 15 15:38:01 UTC 2023

PRIMARY

PUBCHEM

5310966

Created by admin on Fri Dec 15 15:38:01 UTC 2023 , Edited by admin on Fri Dec 15 15:38:01 UTC 2023

PRIMARY

DRUG BANK

DB01273

Created by admin on Fri Dec 15 15:38:01 UTC 2023 , Edited by admin on Fri Dec 15 15:38:01 UTC 2023

PRIMARY

INN

8366

Created by admin on Fri Dec 15 15:38:01 UTC 2023 , Edited by admin on Fri Dec 15 15:38:01 UTC 2023

PRIMARY

WIKIPEDIA

VARENICLINE

Created by admin on Fri Dec 15 15:38:01 UTC 2023 , Edited by admin on Fri Dec 15 15:38:01 UTC 2023

PRIMARY

CHEBI

84500

Created by admin on Fri Dec 15 15:38:01 UTC 2023 , Edited by admin on Fri Dec 15 15:38:01 UTC 2023

PRIMARY

Related Record Type Details


					CK3L47ZRJ4

Varenicline salicylate

SALT/SOLVATE -> PARENT

Amount:


					FW5Z3M5N2Y

VARENICLINE DIHYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:


					2KC7KP5BGA

NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4

TARGET->PARTIAL AGONIST

Amount:


					H9NLT16A4C

VARENICLINE OXALATE

SALT/SOLVATE -> PARENT

Amount:


					82269ASB48

VARENICLINE TARTRATE

SALT/SOLVATE -> PARENT

Amount:


					F2PGH5WAQ4

Varenicline oxalate hydrate

SALT/SOLVATE -> PARENT

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					7YY0U1D3O2

NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2

TARGET->PARTIAL AGONIST

Amount:


					P4J7CHY2JV

Varenicline besylate monohydrate

SALT/SOLVATE -> PARENT

Amount:


					BLQ82778XF

Varenicline sesquioxalate

SALT/SOLVATE -> PARENT

Amount:


					G4MC8K7QCJ

VARENICLINE CITRATE

SALT/SOLVATE -> PARENT

Amount:


					0M77ZW789J

URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 2B7

METABOLIC ENZYME -> SUBSTRATE

Amount:


					L9G5JM632V

Varenicline besylate

SALT/SOLVATE -> PARENT

Amount:


					W6HS99O8ZO

EXCRETED UNCHANGED

Interaction Type:

AMOUNT EXCRETED

Qualification:

URINE

Amount:


					P4J1I8C6CX

NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-7

TARGET -> AGONIST

Amount:

Related Record Type Details


					94F6A84Z7Q

VARENICLINE CARBAMOYL GLUCURONIDE

METABOLITE -> PARENT

Amount:


					TXW5M73PU6

VARENICLINE N-GLUCOSIDE

METABOLITE -> PARENT

Amount:


					DCP9JBZ34N

N-FORMYLVARENICLINE

METABOLITE -> PARENT

Amount:

Related Record Type Details


					W6HS99O8ZO

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC

Tmax	PHARMACOKINETIC				ORAL ADMINISTRATION