MEMANTINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H21N
Molecular Weight	179.3018
Optical Activity	NONE
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of MEMANTINE

Structure Search

SMILES

CC12CC3CC(C)(C1)CC(N)(C3)C2

InChI

InChIKey=BUGYDGFZZOZRHP-UHFFFAOYSA-N

InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C12H21N
Molecular Weight	179.3018
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:59:40 UTC 2023` Edited by `admin` on `Fri Dec 15 15:59:40 UTC 2023`
Record UNII	W8O17SJF3T
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MEMANTINE

Official Name

English

3,5-DIMETHYL-1-ADAMANTANAMINE

Systematic Name

English

D-145

Code

English

MEMANTINE [VANDF]

Common Name

English

MEMANTINE [MI]

Common Name

English

TRICYCLO(3.3.1.1(SUP 3,7))DECAN-1-AMINE, 3,5-DIMETHYL-

Common Name

English

1-AMINO-3,5-DIMETHYLADAMANTANE

Systematic Name

English

NEMDATINE

Brand Name

English

Memantine [WHO-DD]

Common Name

English

NSC-757843

Code

English

memantine [INN]

Common Name

English

DRG-0267

Code

English

3,5-DIMETHYLTRICYCLO(3.3.1.1(SUP 3,7))DECAN-1-AMINE

Systematic Name

English

MEMANTINE [HSDB]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1509

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

NDF-RT

N0000020015

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

NCI_THESAURUS

C38149

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

WHO-ATC

N06DX01

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

WHO-ATC

N06DA52

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

WHO-VATC

QN06DA52

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

NDF-RT

N0000175745

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

WHO-VATC

QN06DX01

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

LIVERTOX

NBK547981

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

WHO-ATC

N06DA53

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

NDF-RT

N0000020015

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

EMA ASSESSMENT REPORTS

NEMDATINE (AUTHORIZED: ALZHEIMER DISEASE)

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

Code System Code Type Description

FDA UNII

W8O17SJF3T

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

PRIMARY

SMS_ID

100000085447

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

PRIMARY

RXCUI

6719

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

PRIMARY

RxNorm

INN

3952

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

PRIMARY

CAS

19982-08-2

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

PRIMARY

EPA CompTox

DTXSID5045174

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

PRIMARY

HSDB

7327

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

PRIMARY

IUPHAR

4253

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

PRIMARY

NCI_THESAURUS

C73269

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

PRIMARY

CLINICAL_TRIALS.GOV

NCT03527472

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

PRIMARY

Memantine for the Treatment of Cognitive Impairment in Systemic Lupus Erythematosus (ClearMEMory)

PUBCHEM

4054

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

PRIMARY

DRUG CENTRAL

1679

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

PRIMARY

NSC

757843

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

PRIMARY

EVMPD

SUB08731MIG

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

PRIMARY

DAILYMED

W8O17SJF3T

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

PRIMARY

DRUG BANK

DB01043

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

PRIMARY

WIKIPEDIA

MEMANTINE

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

PRIMARY

MERCK INDEX

m7167

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

PRIMARY

Merck Index

MESH

D008559

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

PRIMARY

ChEMBL

CHEMBL807

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

PRIMARY

CHEBI

64312

Created by admin on Fri Dec 15 15:59:40 UTC 2023 , Edited by admin on Fri Dec 15 15:59:40 UTC 2023

PRIMARY

Related Record Type Details


					4007E25Z4Z

OCT-3

TRANSPORTER -> INHIBITOR


					482M00274D

OCT-2

TRANSPORTER -> SUBSTRATE


					P4J1I8C6CX

NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-7

TARGET -> INHIBITOR

Comments:

ALZHEIMERS DISEASE DRUG ANTAGONIZING NMDA RECEPTOR, ANTAGONISM OF .ALPHA.7 NACHR IS A SIDE PATHWAY.

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					W8O17SJF3T

MEMANTINE

EXCRETED UNCHANGED

Interaction Type:

AMOUNT EXCRETED

Qualification:

URINE

Amount:


					ONY583280Z

OCT-1

TRANSPORTER -> INHIBITOR


					JY0WD0UA60

MEMANTINE HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:


					482M00274D

OCT-2

TRANSPORTER -> INHIBITOR

Related Record Type Details


					BTI71S2X1M

1-NITROSO-3,5-DIMETHYLADAMANTANE

METABOLITE INACTIVE -> PARENT

Amount:

Related Record Type Details


					W8O17SJF3T

MEMANTINE

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Tmax	PHARMACOKINETIC				ORAL ADMINISTRATION

Biological Half-life	PHARMACOKINETIC				Elimination PHARMACOKINETIC

Volume of Distribution	PHARMACOKINETIC