RIFAPENTINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C47H64N4O12
Molecular Weight	877.0307
Optical Activity	UNSPECIFIED
Defined Stereocenters	9 / 9
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure of RIFAPENTINE

Structure Search

SMILES

CO[C@H]1\C=C\O[C@@]2(C)OC3=C(C2=O)C4=C(O)C(\C=N\N5CCN(CC5)C6CCCC6)=C(NC(=O)C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)C(O)=C4C(O)=C3C

InChI

InChIKey=WDZCUPBHRAEYDL-GZAUEHORSA-N

InChI=1S/C47H64N4O12/c1-24-13-12-14-25(2)46(59)49-37-32(23-48-51-20-18-50(19-21-51)31-15-10-11-16-31)41(56)34-35(42(37)57)40(55)29(6)44-36(34)45(58)47(8,63-44)61-22-17-33(60-9)26(3)43(62-30(7)52)28(5)39(54)27(4)38(24)53/h12-14,17,22-24,26-28,31,33,38-39,43,53-57H,10-11,15-16,18-21H2,1-9H3,(H,49,59)/b13-12+,22-17+,25-14-,48-23+/t24-,26+,27+,28+,33-,38-,39+,43+,47-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C47H64N4O12
Molecular Weight	877.0307
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	9 / 9
E/Z Centers	1
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:32:18 UTC 2023` Edited by `admin` on `Sat Dec 16 17:32:18 UTC 2023`
Record UNII	XJM390A33U
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

RIFAPENTINE

Official Name

English

KTC-1

Code

English

RIFAPENTINE [VANDF]

Common Name

English

R-773

Code

English

DL-473

Code

English

R-77-3

Code

English

rifapentine [INN]

Common Name

English

Rifapentine [WHO-DD]

Common Name

English

RIFAPENTINE [MART.]

Common Name

English

RIFAMYCIN AF/ACPP

Common Name

English

MDL 473

Code

English

RIFAPENTINE [MI]

Common Name

English

3-((4-CYCLOPENTYL-1-PIPERAZINYL)IMINO)METHYL)RIFAMYCIN

Common Name

English

RIFAMYCIN, 3-(((4-CYCLOPENTYL-1-PIPERAZINYL)IMINO)METHYL)-

Common Name

English

3-(((4-CYCLOPENTYL-1-PIPERAZINYL)IMINO)METHYL)RIFAMYCIN

Common Name

English

RIFAPENTIN

Common Name

English

RIFAPENTINE [ORANGE BOOK]

Common Name

English

PRIFITIN

Brand Name

English

PRIFTIN

Brand Name

English

ANTIBIOTIC DL-473IT

Code

English

RIFAPENTINE [USAN]

Common Name

English

MDL-473

Code

English

3-[N-(4-Cyclopentyl-1-piperazinyl)formimidoyl]rifamycin

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C280

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

NDF-RT

N0000007911

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

FDA ORPHAN DRUG

89495

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

NDF-RT

N0000007911

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

NDF-RT

N0000007911

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

WHO-VATC

QJ04AB05

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

NDF-RT

N0000175501

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

FDA ORPHAN DRUG

89695

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

LIVERTOX

NBK548547

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

EU-Orphan Drug

EU/3/10/750

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

FDA ORPHAN DRUG

89595

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

WHO-ATC

J04AB05

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

NDF-RT

N0000007911

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

Code System Code Type Description

EVMPD

SUB10311MIG

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

PRIMARY

SMS_ID

100000080562

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

PRIMARY

MERCK INDEX

m9614

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

PRIMARY

Merck Index

NCI_THESAURUS

C66516

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

PRIMARY

WIKIPEDIA

Rifapentine

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

PRIMARY

FDA UNII

XJM390A33U

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

PRIMARY

DRUG BANK

DB01201

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

PRIMARY

DAILYMED

XJM390A33U

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

PRIMARY

INN

4765

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

PRIMARY

LACTMED

Rifapentine

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

PRIMARY

CHEBI

45304

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

PRIMARY

EPA CompTox

DTXSID8041115

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

PRIMARY

RXCUI

35617

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

PRIMARY

RxNorm

USAN

X-15

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

PRIMARY

CAS

61379-65-5

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

PRIMARY

ECHA (EC/EINECS)

262-743-9

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

PRIMARY

DRUG CENTRAL

2378

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

PRIMARY

PUBCHEM

135403821

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

PRIMARY

ChEMBL

CHEMBL1660

Created by admin on Sat Dec 16 17:32:19 UTC 2023 , Edited by admin on Sat Dec 16 17:32:19 UTC 2023

PRIMARY

Related Record Type Details


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Comments:

The bound concentration increased slightly (,2%) as the concentration of 14C-rifapentine increased from 0.5 to 10 mg/ml. At concentrations above 10 mg/ml, protein binding did not appear to vary with increasing concentration.

Interaction Type:

BINDING

Amount:


					805SU96HKF

CYTOCHROME P450 3A5

METABOLIC ENZYME -> INDUCER


					XJM390A33U

EXCRETED UNCHANGED

Qualification:

FECAL

Amount:


					5915QBW8LA

RIFAPENTINE HYDROCHLORIDE

SALT/SOLVATE -> PARENT


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> INDUCER


					XJM390A33U

EXCRETED UNCHANGED

Qualification:

URINE

Amount:

Related Record Type Details


					29A0K44SJO

25-DESACETYLRIFAPENTINE

METABOLITE -> PARENT

Qualification:

URINE

Amount:


					C87UV623UL

3-FORMYLRIFAMYCIN

METABOLITE -> PARENT

Qualification:

FECAL

Amount:


					W23H162QVC

3-FORMYL-25-DESACETYLRIFAMYCIN

METABOLITE -> PARENT

Qualification:

FECAL

Amount:


					29A0K44SJO

25-DESACETYLRIFAPENTINE

METABOLITE -> PARENT

Qualification:

FECAL

Amount:

Related Record Type Details


					XJM390A33U

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC				ORAL ADMINISTRATION

Tmax	PHARMACOKINETIC				ORAL ADMINISTRATION