INDOMETHACIN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H16ClNO4
Molecular Weight	357.788
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of INDOMETHACIN

Structure Search

SMILES

COC1=CC=C2N(C(=O)C3=CC=C(Cl)C=C3)C(C)=C(CC(O)=O)C2=C1

InChI

InChIKey=CGIGDMFJXJATDK-UHFFFAOYSA-N

InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)

HIDE SMILES / InChI

Molecular Formula	C19H16ClNO4
Molecular Weight	357.788
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:07:35 UTC 2023` Edited by `admin` on `Fri Dec 15 15:07:35 UTC 2023`
Record UNII	XXE1CET956
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

INDOMETHACIN

Official Name

English

ACONIP

Brand Name

English

INDO-LEMMON

Brand Name

English

1H-INDOLE-3-ACETIC ACID, 1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-

Systematic Name

English

INDOMETACINUM [WHO-IP LATIN]

Common Name

English

1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID

Systematic Name

English

INDOMETACIN [MART.]

Common Name

English

NSC-77541

Code

English

INDOMETACIN

Official Name

English

indometacin [INN]

Common Name

English

INDOMETHACIN [MI]

Common Name

English

(1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOL-3-YL)ACETIC ACID

Systematic Name

English

INDOMETHACIN [ORANGE BOOK]

Common Name

English

INDOMETHACIN [USP MONOGRAPH]

Common Name

English

ACEMETACIN IMPURITY B [EP IMPURITY]

Common Name

English

REUMACIDE

Common Name

English

TIVORBEX

Brand Name

English

INDOMETHACIN [USP-RS]

Common Name

English

INDOMETHACIN [VANDF]

Common Name

English

NSC-757061

Code

English

Indometacin [WHO-DD]

Common Name

English

1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID

Common Name

English

INDOMETACIN [JAN]

Common Name

English

INDOMETHACIN [USAN]

Common Name

English

DURAMETACIN

Common Name

English

INDOMETHACIN [HSDB]

Common Name

English

INDOCIN

Brand Name

English

INDOMETACIN [EP MONOGRAPH]

Common Name

English

INDOMETACIN [WHO-IP]

Common Name

English

Classification Tree Code System Code

NDF-RT

N0000000160

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

NCI_THESAURUS

C1323

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

WHO-VATC

QS01BC01

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

WHO-VATC

QC01EB03

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

NCI_THESAURUS

C54677

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

NDF-RT

N0000175721

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

LIVERTOX

NBK548001

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

WHO-ATC

M02AA23

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

NDF-RT

N0000175722

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

WHO-VATC

QM01AB01

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

WHO-ATC

M01AB01

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

WHO-ATC

S01BC01

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

WHO-VATC

QM02AA23

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

WHO-ATC

S01CC02

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

WHO-VATC

QM01AB51

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

WHO-ATC

M01AB51

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

WHO-ATC

C01EB03

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

Code System Code Type Description

ChEMBL

CHEMBL6

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

PRIMARY

DRUG BANK

DB00328

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

PRIMARY

MERCK INDEX

m6279

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

PRIMARY

Merck Index

RXCUI

5781

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

PRIMARY

RxNorm

MESH

D007213

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

PRIMARY

LACTMED

Indomethacin

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

PRIMARY

DAILYMED

XXE1CET956

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

PRIMARY

EPA CompTox

DTXSID9020740

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

PRIMARY

EVMPD

SUB08180MIG

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

PRIMARY

SMS_ID

100000092758

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

PRIMARY

CHEBI

49662

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

PRIMARY

NSC

757061

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

PRIMARY

FDA UNII

XXE1CET956

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

PRIMARY

INN

1524

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

PRIMARY

NSC

77541

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

PRIMARY

RS_ITEM_NUM

1341001

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

PRIMARY

HSDB

3101

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

PRIMARY

PUBCHEM

3715

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

PRIMARY

WHO INTERNATIONAL PHARMACOPEIA

INDOMETHACIN

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

PRIMARY

Description: A white or a pale yellow, crystalline powder; odourless or almost odourless. Solubility: Practically insoluble in water; sparingly soluble in ethanol (~750 g/l) TS and ether R. Category: Analgesic; anti-inflammatory. Storage: Indometacin should be kept in a well-closed container, protected from light. Additional information: Indometacin exhibits polymorphism. The polymorph specified in the monograph corresponds to the crystal form of indometacin RS.Definition: Indometacin contains not less than 98.0% and not more than 101.0% of C19H16ClNO4, calculated with reference to the dried substance.

DRUG CENTRAL

1440

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

PRIMARY

NCI_THESAURUS

C576

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

PRIMARY

CAS

53-86-1

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

PRIMARY

IUPHAR

1909

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

PRIMARY

ECHA (EC/EINECS)

200-186-5

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

PRIMARY

WIKIPEDIA

INDOMETACIN

Created by admin on Fri Dec 15 15:07:35 UTC 2023 , Edited by admin on Fri Dec 15 15:07:35 UTC 2023

PRIMARY

Related Record Type Details


					ZWJ2Y6JZWY

OAT-3

TRANSPORTER -> INHIBITOR


					4AF605U6JN

MRP-2

TRANSPORTER -> INHIBITOR


					4HZ67LW8L7

OAT-4

TRANSPORTER -> INHIBITOR


					XXE1CET956

BASIS OF STRENGTH->SUBSTANCE

Interaction Type:

ASSAY (HPLC)

Qualification:

USP

Amount:


					XXE1CET956

BASIS OF STRENGTH->SUBSTANCE

Interaction Type:

ASSAY (TITRATION)

Qualification:

EP

Amount:


					5840721PJZ

OAT-2

TRANSPORTER -> INHIBITOR

Qualification:

IC50

Amount:


					Y49M64GZ4Q

MRP-1

TRANSPORTER -> INHIBITOR

Amount:


					I81U7H57XI

OAT-1

TRANSPORTER -> INHIBITOR


					O8CY03FM0A

4-CHLORO-N-(4-METHOXY-2-(1-METHYLENE-2-OXO-PROPYL)PHENYL)BENZAMIDE

DEGRADENT -> PARENT

Amount:


					D8T754TT2I

COX-2

TARGET -> INHIBITOR

Qualification:

IC50

Amount:


					0IMX38M2GG

INDOMETHACIN SODIUM

SALT/SOLVATE -> PARENT

Amount:

1C9D998830

INDOMETHACIN SODIUM ANHYDROUS

SALT/SOLVATE -> PARENT

Amount:


					E6HDG0QI46

COX-1

TARGET -> INHIBITOR

Qualification:

IC50

Amount:

Related Record Type Details


					UYW56F3GVS

2-(5-HYDROXY-2-METHYL-1H-INDOL-3-YL)ACETIC ACID

METABOLITE -> PARENT

Amount:


					MB2386WGG8

INDOMETHACIN FARNESIL

PRODRUG -> METABOLITE ACTIVE

Amount:


					E2JR7DHX5T

.BETA.-D-GLUCOPYRANOSE, 1-(5-HYDROXY-2-METHYL-1H-INDOLE-3-ACETATE)

METABOLITE -> PARENT

Amount:


					K89VS3UAD8

5-HYDROXYINDOMETHACIN

METABOLITE -> PARENT

Amount:


					B7MV2JQJ3W

INDOMETHACIN GLUCURONIDE

METABOLITE -> PARENT

Amount:

Related Record Type Details


					5V141XK28X

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					8AON0U1UBT

INDOMETHACIN ETHYL

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					KY9AD0AQM0

De(chlorobenzoyl)indomethacin

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					KG2PT836RS

INDOMETHACIN DIAMIDE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					IC7888DF4L

P-CHLOROBENZOIC ACID

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:

Related Record Type Details


					XXE1CET956

ACTIVE MOIETY

Amount: