TRAZODONE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H22ClN5O
Molecular Weight	371.864
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of TRAZODONE

Structure Search

SMILES

ClC1=CC=CC(=C1)N2CCN(CCCN3N=C4C=CC=CN4C3=O)CC2

InChI

InChIKey=PHLBKPHSAVXXEF-UHFFFAOYSA-N

InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2

HIDE SMILES / InChI

Molecular Formula	C19H22ClN5O
Molecular Weight	371.864
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:03:21 UTC 2023` Edited by `admin` on `Fri Dec 15 15:03:21 UTC 2023`
Record UNII	YBK48BXK30
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

TRAZODONE

Official Name

English

TRITTICO

Brand Name

English

1,2,4-TRIAZOLO(4,3-A)PYRIDIN-3(2H)-ONE, 2-(3-(4-(3-CHLOROPHENYL)-1-PIPERAZINYL)PROPYL)-

Systematic Name

English

TRAZODONE [VANDF]

Common Name

English

2-(3-(4-(M-CHLOROPHENYL)-1-PIPERAZINYL)PROPYL)-S-TRIAZOLO(4,3-A)PYRIDIN-3(2H)-ONE

Systematic Name

English

TRAZODONE [MI]

Common Name

English

Trazodone [WHO-DD]

Common Name

English

trazodone [INN]

Common Name

English

J10.767K

Code

English

Classification Tree Code System Code

WHO-ATC

N06AX05

Created by admin on Fri Dec 15 15:03:21 UTC 2023 , Edited by admin on Fri Dec 15 15:03:21 UTC 2023

WHO-VATC

QN06AX05

Created by admin on Fri Dec 15 15:03:21 UTC 2023 , Edited by admin on Fri Dec 15 15:03:21 UTC 2023

LIVERTOX

NBK548557

Created by admin on Fri Dec 15 15:03:21 UTC 2023 , Edited by admin on Fri Dec 15 15:03:21 UTC 2023

NDF-RT

N0000175696

Created by admin on Fri Dec 15 15:03:21 UTC 2023 , Edited by admin on Fri Dec 15 15:03:21 UTC 2023

NCI_THESAURUS

C265

Created by admin on Fri Dec 15 15:03:21 UTC 2023 , Edited by admin on Fri Dec 15 15:03:21 UTC 2023

FDA ORPHAN DRUG

593917

Created by admin on Fri Dec 15 15:03:21 UTC 2023 , Edited by admin on Fri Dec 15 15:03:21 UTC 2023

Code System Code Type Description

IUPHAR

213

Created by admin on Fri Dec 15 15:03:21 UTC 2023 , Edited by admin on Fri Dec 15 15:03:21 UTC 2023

PRIMARY

DAILYMED

YBK48BXK30

Created by admin on Fri Dec 15 15:03:21 UTC 2023 , Edited by admin on Fri Dec 15 15:03:21 UTC 2023

PRIMARY

WIKIPEDIA

TRAZODONE

Created by admin on Fri Dec 15 15:03:21 UTC 2023 , Edited by admin on Fri Dec 15 15:03:21 UTC 2023

PRIMARY

EPA CompTox

DTXSID5045043

Created by admin on Fri Dec 15 15:03:21 UTC 2023 , Edited by admin on Fri Dec 15 15:03:21 UTC 2023

PRIMARY

MESH

D014196

Created by admin on Fri Dec 15 15:03:21 UTC 2023 , Edited by admin on Fri Dec 15 15:03:21 UTC 2023

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DRUG CENTRAL

2717

Created by admin on Fri Dec 15 15:03:21 UTC 2023 , Edited by admin on Fri Dec 15 15:03:21 UTC 2023

PRIMARY

DRUG BANK

DB00656

Created by admin on Fri Dec 15 15:03:21 UTC 2023 , Edited by admin on Fri Dec 15 15:03:21 UTC 2023

PRIMARY

CHEBI

9654

Created by admin on Fri Dec 15 15:03:21 UTC 2023 , Edited by admin on Fri Dec 15 15:03:21 UTC 2023

PRIMARY

HSDB

7048

Created by admin on Fri Dec 15 15:03:21 UTC 2023 , Edited by admin on Fri Dec 15 15:03:21 UTC 2023

PRIMARY

ChEMBL

CHEMBL621

Created by admin on Fri Dec 15 15:03:21 UTC 2023 , Edited by admin on Fri Dec 15 15:03:21 UTC 2023

PRIMARY

EVMPD

SUB11224MIG

Created by admin on Fri Dec 15 15:03:21 UTC 2023 , Edited by admin on Fri Dec 15 15:03:21 UTC 2023

PRIMARY

RXCUI

10737

Created by admin on Fri Dec 15 15:03:21 UTC 2023 , Edited by admin on Fri Dec 15 15:03:21 UTC 2023

PRIMARY

RxNorm

CAS

19794-93-5

Created by admin on Fri Dec 15 15:03:21 UTC 2023 , Edited by admin on Fri Dec 15 15:03:21 UTC 2023

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MERCK INDEX

m11010

Created by admin on Fri Dec 15 15:03:21 UTC 2023 , Edited by admin on Fri Dec 15 15:03:21 UTC 2023

PRIMARY

Merck Index

PUBCHEM

5533

Created by admin on Fri Dec 15 15:03:21 UTC 2023 , Edited by admin on Fri Dec 15 15:03:21 UTC 2023

PRIMARY

INN

2878

Created by admin on Fri Dec 15 15:03:21 UTC 2023 , Edited by admin on Fri Dec 15 15:03:21 UTC 2023

PRIMARY

NCI_THESAURUS

C29510

Created by admin on Fri Dec 15 15:03:21 UTC 2023 , Edited by admin on Fri Dec 15 15:03:21 UTC 2023

PRIMARY

SMS_ID

100000077477

Created by admin on Fri Dec 15 15:03:21 UTC 2023 , Edited by admin on Fri Dec 15 15:03:21 UTC 2023

PRIMARY

FDA UNII

YBK48BXK30

Created by admin on Fri Dec 15 15:03:21 UTC 2023 , Edited by admin on Fri Dec 15 15:03:21 UTC 2023

PRIMARY

LACTMED

Trazodone

Created by admin on Fri Dec 15 15:03:21 UTC 2023 , Edited by admin on Fri Dec 15 15:03:21 UTC 2023

PRIMARY

ECHA (EC/EINECS)

243-317-1

Created by admin on Fri Dec 15 15:03:21 UTC 2023 , Edited by admin on Fri Dec 15 15:03:21 UTC 2023

PRIMARY

Related Record Type Details


					8E4LAA4357

CYTOCHROME P450 2D6

METABOLIC ENZYME -> SUBSTRATE


					6E8ZO8LRNM

TRAZODONE HYDROCHLORIDE

SALT/SOLVATE -> PARENT


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE

Related Record Type Details


					WZ2CBY8JCL

2-(3-(4-(3-CHLORO-4-HYDROXY-PHENYL)PIPERAZIN-1-YL)PROPYL)-7,8-DIHYDROXY-7,8-DIHYDRO-(1,2,4)TRIAZOLO(4,3-A)PYRIDIN-3-ONE

METABOLITE -> PARENT


					U3ZBN4W677

4-HYDROXYTRAZODONE

METABOLITE -> PARENT


					R5K2FR3NR5

OXIRENO(C)-1,2,4-TRIAZOLO(4,3-A)PYRIDIN-3(2H)-ONE, 2-(3-(4-(3-CHLORO-4-HYDROXYPHENYL)-1-PIPERAZINYL)PROPYL)-6A,7A-DIHYDRO-

METABOLITE -> PARENT


					REY0CNO998

M-CHLOROPHENYLPIPERAZINE

METABOLITE ACTIVE -> PARENT


					T6S875D8JF

TRIAZOLOPYRIDINONE-PROPIONIC ACID

METABOLITE -> PARENT

Related Record Type Details


					YBK48BXK30

TRAZODONE

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Tmax	PHARMACOKINETIC				EFFECT OF FOOD PHARMACOKINETIC

MAXIMUM TOLERATED DOSE	TOXICITY

ORAL BIOAVAILABILITY	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC				EXTENDED RELEASE PHARMACOKINETIC

Tmax	PHARMACOKINETIC

Volume of Distribution	PHARMACOKINETIC

MAXIMUM TOLERATED DOSE	TOXICITY

PROTEIN BINDING	PHARMACOKINETIC

MAXIMUM TOLERATED DOSE	TOXICITY

Route of Elimination	PHARMACOKINETIC				EXCRETED UNCHANGED PHARMACOKINETIC

Route of Elimination	PHARMACOKINETIC

Route of Elimination	PHARMACOKINETIC