AZELASTINE

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C22H24ClN3O
Molecular Weight	381.898
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of AZELASTINE

Structure Search

SMILES

CN1CCCC(CC1)N2N=C(CC3=CC=C(Cl)C=C3)C4=CC=CC=C4C2=O

InChI

InChIKey=MBUVEWMHONZEQD-UHFFFAOYSA-N

InChI=1S/C22H24ClN3O/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16/h2-3,6-11,18H,4-5,12-15H2,1H3

HIDE SMILES / InChI

Molecular Formula	C22H24ClN3O
Molecular Weight	381.898
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:58:21 UTC 2023` Edited by `admin` on `Fri Dec 15 18:58:21 UTC 2023`
Record UNII	ZQI909440X
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

AZELASTINE

Official Name

English

AZELASTINE [VANDF]

Common Name

English

azelastine [INN]

Common Name

English

1(2H)-PHTHALAZINONE, 4-((4-CHLOROPHENYL)METHYL)-2-(HEXAHYDRO-1-METHYL-1H-AZEPIN-4-YL)-

Systematic Name

English

NSC-758971

Code

English

4-(4-CHLOROBENZYL)-2-(1-METHYLAZEPAN-4-YL)PHTHALAZIN-1(2H)-ONE

Systematic Name

English

Azelastine [WHO-DD]

Common Name

English

AZELASTINE [MI]

Common Name

English

Classification Tree Code System Code

NDF-RT

N0000000190

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

WHO-VATC

QS01GX07

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

NCI_THESAURUS

C29578

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

WHO-ATC

S01GX07

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

WHO-ATC

R06AX19

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

WHO-VATC

QR06AX19

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

WHO-ATC

R01AC03

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

WHO-VATC

QR01AC03

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

NDF-RT

N0000175519

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

NDF-RT

N0000175587

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

Code System Code Type Description

MESH

C020976

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

PRIMARY

INN

4074

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

PRIMARY

CHEBI

2951

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

PRIMARY

IUPHAR

7121

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

PRIMARY

NCI_THESAURUS

C61643

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

PRIMARY

HSDB

7991

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

PRIMARY

RXCUI

18603

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

PRIMARY

RxNorm

PUBCHEM

2267

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

PRIMARY

MERCK INDEX

m2169

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

PRIMARY

Merck Index

DAILYMED

ZQI909440X

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

PRIMARY

NSC

758971

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

PRIMARY

DRUG CENTRAL

271

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

PRIMARY

DRUG BANK

DB00972

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

PRIMARY

EPA CompTox

DTXSID6022638

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

PRIMARY

WIKIPEDIA

AZELASTINE

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

PRIMARY

LACTMED

Azelastine

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

PRIMARY

SMS_ID

100000086100

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

PRIMARY

ChEMBL

CHEMBL639

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

PRIMARY

EVMPD

SUB05649MIG

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

PRIMARY

CAS

58581-89-8

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

PRIMARY

CHEBI

2950

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

PRIMARY

FDA UNII

ZQI909440X

Created by admin on Fri Dec 15 18:58:21 UTC 2023 , Edited by admin on Fri Dec 15 18:58:21 UTC 2023

PRIMARY

Related Record Type Details


					434T9969GH

AZELASTINE, (R)-

ENANTIOMER -> RACEMATE


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE

Interaction Type:

MAJOR


					7Y9YE1DOYQ

AZELASTINE, (S)-

ENANTIOMER -> RACEMATE


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					8E4LAA4357

CYTOCHROME P450 2D6

METABOLIC ENZYME -> SUBSTRATE

Interaction Type:

MAJOR


					0L591QR10I

AZELASTINE HYDROCHLORIDE

SALT/SOLVATE -> PARENT


					28XBT591QG

HISTAMINE H1 RECEPTOR

TARGET -> INHIBITOR

Related Record Type Details


					8W9SOB28Q4

DESMETHYLAZELASTINE

METABOLITE ACTIVE -> PARENT

Comments:

Desmethylazelastine, by the cytochrome P450 enzyme system. The specific P450 isoforms responsible for the biotransformation of azelastine have not been identified

Related Record Type Details


					M8VQ6F3WFE

4-((4-CHLOROPHENYL)METHYL)-2-(2-(1-METHYL-2-PYRROLIDINYL)ETHYL)-1(2H)-PHTHALAZINONE

IMPURITY -> PARENT

Amount:

Related Record Type Details


					ZQI909440X

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC

Tmax	PHARMACOKINETIC				SINGLE DOSE INTRANASAL ADMINISTRATION