TIPRANAVIR

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C31H33F3N2O5S
Molecular Weight	602.664
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of TIPRANAVIR

Structure Search

SMILES

CCC[C@@]2(CCC1=CC=CC=C1)CC(O)=C([C@H](CC)C3=CC=CC(NS(=O)(=O)C4=NC=C(C=C4)C(F)(F)F)=C3)C(=O)O2

InChI

InChIKey=SUJUHGSWHZTSEU-FYBSXPHGSA-N

InChI=1S/C31H33F3N2O5S/c1-3-16-30(17-15-21-9-6-5-7-10-21)19-26(37)28(29(38)41-30)25(4-2)22-11-8-12-24(18-22)36-42(39,40)27-14-13-23(20-35-27)31(32,33)34/h5-14,18,20,25,36-37H,3-4,15-17,19H2,1-2H3/t25-,30-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C31H33F3N2O5S
Molecular Weight	602.664
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:26:43 UTC 2023` Edited by `admin` on `Fri Dec 15 16:26:43 UTC 2023`
Record UNII	ZZT404XD09
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

TIPRANAVIR

Official Name

English

3'-((1R)-1-((6R)-5,6-DIHYDRO-4-HYDROXY-2-OXO-6-PHENETHYL-6-PROPYL-2H-PYRAN-3-YL)PROPYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINESULFONANILIDE

Systematic Name

English

TIPRANAVIR [MART.]

Common Name

English

TIPRANAVIR [EMA EPAR]

Common Name

English

TIPRANAVIR [ORANGE BOOK]

Common Name

English

APTIVUS

Brand Name

English

tipranavir [INN]

Common Name

English

Tipranavir [WHO-DD]

Common Name

English

TIPRANAVIR [VANDF]

Common Name

English

TIPRANAVIR [MI]

Common Name

English

Classification Tree Code System Code

NDF-RT

N0000000246

Created by admin on Fri Dec 15 16:26:43 UTC 2023 , Edited by admin on Fri Dec 15 16:26:43 UTC 2023

NCI_THESAURUS

C97366

Created by admin on Fri Dec 15 16:26:43 UTC 2023 , Edited by admin on Fri Dec 15 16:26:43 UTC 2023

EMA ASSESSMENT REPORTS

APTIVUS (AUTHORIZED: HIV INFECTIONS)

Created by admin on Fri Dec 15 16:26:43 UTC 2023 , Edited by admin on Fri Dec 15 16:26:43 UTC 2023

WHO-VATC

QJ05AE09

Created by admin on Fri Dec 15 16:26:43 UTC 2023 , Edited by admin on Fri Dec 15 16:26:43 UTC 2023

LIVERTOX

NBK548389

Created by admin on Fri Dec 15 16:26:43 UTC 2023 , Edited by admin on Fri Dec 15 16:26:43 UTC 2023

WHO-ATC

J05AE09

Created by admin on Fri Dec 15 16:26:43 UTC 2023 , Edited by admin on Fri Dec 15 16:26:43 UTC 2023

NDF-RT

N0000175889

Created by admin on Fri Dec 15 16:26:43 UTC 2023 , Edited by admin on Fri Dec 15 16:26:43 UTC 2023

Code System Code Type Description

RXCUI

190548

Created by admin on Fri Dec 15 16:26:43 UTC 2023 , Edited by admin on Fri Dec 15 16:26:43 UTC 2023

PRIMARY

RxNorm

CHEBI

63628

Created by admin on Fri Dec 15 16:26:43 UTC 2023 , Edited by admin on Fri Dec 15 16:26:43 UTC 2023

PRIMARY

CAS

174484-41-4

Created by admin on Fri Dec 15 16:26:43 UTC 2023 , Edited by admin on Fri Dec 15 16:26:43 UTC 2023

PRIMARY

SMS_ID

100000085237

Created by admin on Fri Dec 15 16:26:43 UTC 2023 , Edited by admin on Fri Dec 15 16:26:43 UTC 2023

PRIMARY

WIKIPEDIA

TIPRANAVIR

Created by admin on Fri Dec 15 16:26:43 UTC 2023 , Edited by admin on Fri Dec 15 16:26:43 UTC 2023

PRIMARY

PUBCHEM

54682461

Created by admin on Fri Dec 15 16:26:43 UTC 2023 , Edited by admin on Fri Dec 15 16:26:43 UTC 2023

PRIMARY

MESH

C107201

Created by admin on Fri Dec 15 16:26:43 UTC 2023 , Edited by admin on Fri Dec 15 16:26:43 UTC 2023

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LACTMED

Tipranavir

Created by admin on Fri Dec 15 16:26:43 UTC 2023 , Edited by admin on Fri Dec 15 16:26:43 UTC 2023

PRIMARY

FDA UNII

ZZT404XD09

Created by admin on Fri Dec 15 16:26:43 UTC 2023 , Edited by admin on Fri Dec 15 16:26:43 UTC 2023

PRIMARY

DAILYMED

ZZT404XD09

Created by admin on Fri Dec 15 16:26:43 UTC 2023 , Edited by admin on Fri Dec 15 16:26:43 UTC 2023

PRIMARY

HSDB

8083

Created by admin on Fri Dec 15 16:26:43 UTC 2023 , Edited by admin on Fri Dec 15 16:26:43 UTC 2023

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MERCK INDEX

m10885

Created by admin on Fri Dec 15 16:26:43 UTC 2023 , Edited by admin on Fri Dec 15 16:26:43 UTC 2023

PRIMARY

Merck Index

ChEMBL

CHEMBL222559

Created by admin on Fri Dec 15 16:26:43 UTC 2023 , Edited by admin on Fri Dec 15 16:26:43 UTC 2023

PRIMARY

EVMPD

SUB04883MIG

Created by admin on Fri Dec 15 16:26:43 UTC 2023 , Edited by admin on Fri Dec 15 16:26:43 UTC 2023

PRIMARY

EPA CompTox

DTXSID6048622

Created by admin on Fri Dec 15 16:26:43 UTC 2023 , Edited by admin on Fri Dec 15 16:26:43 UTC 2023

PRIMARY

NCI_THESAURUS

C66603

Created by admin on Fri Dec 15 16:26:43 UTC 2023 , Edited by admin on Fri Dec 15 16:26:43 UTC 2023

PRIMARY

DRUG BANK

DB00932

Created by admin on Fri Dec 15 16:26:43 UTC 2023 , Edited by admin on Fri Dec 15 16:26:43 UTC 2023

PRIMARY

DRUG CENTRAL

3609

Created by admin on Fri Dec 15 16:26:43 UTC 2023 , Edited by admin on Fri Dec 15 16:26:43 UTC 2023

PRIMARY

INN

7774

Created by admin on Fri Dec 15 16:26:43 UTC 2023 , Edited by admin on Fri Dec 15 16:26:43 UTC 2023

PRIMARY

Related Record Type Details


					9BAN2XG1ZW

TIPRANAVIR DISODIUM

SALT/SOLVATE -> PARENT


					22ES734693

MULTIDRUG RESISTANCE PROTEIN 1

TRANSPORTER -> INDUCER


					859A956UY8

HUMAN IMMUNODEFICIENCY VIRUS TYPE 1

TARGET ORGANISM->INHIBITOR

Comments:

Tipranavir (TPV) is a non-peptidic HIV-1 protease inhibitor that inhibits the virus-specific processing of the viral Gag and Gag-Pol polyproteins in HIV-1 infected cells, thus preventing formation of mature virions.

Amount:


					ZZT404XD09

EXCRETED UNCHANGED

Interaction Type:

MAJOR

Qualification:

FECAL

Amount:


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE

Comments:

COADMINSTERED WITH RITONAVIR TO INCREASE BIOAVAILABILITY


					22ES734693

MULTIDRUG RESISTANCE PROTEIN 1

TRANSPORTER -> SUBSTRATE

Comments:

COADMINSTERED WITH RITONAVIR TO INCREASE BIOAVAILABILITY


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:

Related Record Type Details


					AAY9UHT656

(2R)-3,6-DIHYDRO-6-OXO-2-(2-PHENYLETHYL)-2-PROPYL-5-((1R)-1-(3-(((5-(TRIFLUOROMETHYL)-2-PYRIDINYL)SULFONYL)AMINO)PHENYL)PROPYL)-2H-PYRAN-4-YL .BETA.-D-GLUCOPYRANOSIDURONIC ACID

METABOLITE -> PARENT

Interaction Type:

MINOR

Related Record Type Details


					ZZT404XD09

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Tmax	PHARMACOKINETIC

Biological Half-life