U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C24H29NO3.ClH
Molecular Weight 415.953
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DONEPEZIL HYDROCHLORIDE

SMILES

Cl.COC1=CC2=C(C=C1OC)C(=O)C(CC3CCN(CC4=CC=CC=C4)CC3)C2

InChI

InChIKey=XWAIAVWHZJNZQQ-UHFFFAOYSA-N
InChI=1S/C24H29NO3.ClH/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H

HIDE SMILES / InChI
Molecular Formula C24H29NO3
Molecular Weight 379.492
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:31:20 UTC 2023
Edited
by admin
on Fri Dec 15 15:31:20 UTC 2023
Record UNII
3O2T2PJ89D
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DONEPEZIL HYDROCHLORIDE
JAN   MART.   MI   ORANGE BOOK   USAN   VANDF   WHO-DD  
USAN  
Official Name English
BNAG
Common Name English
NAMZARIC COMPONENT DONEPEZIL HYDROCHLORIDE
Brand Name English
Donepezil hydrochloride [WHO-DD]
Common Name English
(±)-2-((1-BENZYL-4-PIPERIDYL)METHYL)-5,6-DIMETHOXY-1-INDANONE HYDROCHLORIDE
Systematic Name English
DONEPEZIL HYDROCHLORIDE [JAN]
Common Name English
DONEPEZIL HYDROCHLORIDE [EP MONOGRAPH]
Common Name English
NSC-737535
Code English
DONEPEZIL HYDROCHLORIDE [ORANGE BOOK]
Common Name English
DONEPEZIL HYDROCHLORIDE [USP-RS]
Common Name English
DONEPEZIL HYDROCHLORIDE [MART.]
Common Name English
E2020
Code English
DONEPEZIL HYDROCHLORIDE [USP MONOGRAPH]
Common Name English
E-2020
Code English
NSC-758882
Code English
DONEPEZIL HYDROCHLORIDE COMPONENT OF NAMZARIC
Brand Name English
DONEPEZIL HCL
Common Name English
DONEPEZIL HYDROCHLORIDE [MI]
Common Name English
DONEPEZIL HYDROCHLORIDE [VANDF]
Common Name English
ARICEPT
Brand Name English
DONEPEZIL HYDROCHLORIDE [USAN]
Common Name English
ADLARITY
Brand Name English
Classification Tree Code System Code
EMA ASSESSMENT REPORTS BALAXUR (REFUSED: ALZHEIMER DISEASE)
Created by admin on Fri Dec 15 15:31:20 UTC 2023 , Edited by admin on Fri Dec 15 15:31:20 UTC 2023
EMA ASSESSMENT REPORTS ACRESCENT (REFUSED: ALZHEIMER DISEASE)
Created by admin on Fri Dec 15 15:31:20 UTC 2023 , Edited by admin on Fri Dec 15 15:31:20 UTC 2023
NCI_THESAURUS C47792
Created by admin on Fri Dec 15 15:31:20 UTC 2023 , Edited by admin on Fri Dec 15 15:31:20 UTC 2023
Code System Code Type Description
NSC
737535
Created by admin on Fri Dec 15 15:31:20 UTC 2023 , Edited by admin on Fri Dec 15 15:31:20 UTC 2023
PRIMARY
DAILYMED
3O2T2PJ89D
Created by admin on Fri Dec 15 15:31:20 UTC 2023 , Edited by admin on Fri Dec 15 15:31:20 UTC 2023
PRIMARY
FDA UNII
3O2T2PJ89D
Created by admin on Fri Dec 15 15:31:20 UTC 2023 , Edited by admin on Fri Dec 15 15:31:20 UTC 2023
PRIMARY
CHEBI
4696
Created by admin on Fri Dec 15 15:31:20 UTC 2023 , Edited by admin on Fri Dec 15 15:31:20 UTC 2023
PRIMARY
ChEMBL
CHEMBL502
Created by admin on Fri Dec 15 15:31:20 UTC 2023 , Edited by admin on Fri Dec 15 15:31:20 UTC 2023
PRIMARY
PUBCHEM
5741
Created by admin on Fri Dec 15 15:31:20 UTC 2023 , Edited by admin on Fri Dec 15 15:31:20 UTC 2023
PRIMARY
SMS_ID
100000091200
Created by admin on Fri Dec 15 15:31:20 UTC 2023 , Edited by admin on Fri Dec 15 15:31:20 UTC 2023
PRIMARY
MERCK INDEX
m4738
Created by admin on Fri Dec 15 15:31:20 UTC 2023 , Edited by admin on Fri Dec 15 15:31:20 UTC 2023
PRIMARY Merck Index
DRUG BANK
DBSALT000938
Created by admin on Fri Dec 15 15:31:20 UTC 2023 , Edited by admin on Fri Dec 15 15:31:20 UTC 2023
PRIMARY
NSC
758882
Created by admin on Fri Dec 15 15:31:20 UTC 2023 , Edited by admin on Fri Dec 15 15:31:20 UTC 2023
PRIMARY
EVMPD
SUB13647MIG
Created by admin on Fri Dec 15 15:31:20 UTC 2023 , Edited by admin on Fri Dec 15 15:31:20 UTC 2023
PRIMARY
USAN
HH-52
Created by admin on Fri Dec 15 15:31:20 UTC 2023 , Edited by admin on Fri Dec 15 15:31:20 UTC 2023
PRIMARY
RS_ITEM_NUM
1224981
Created by admin on Fri Dec 15 15:31:20 UTC 2023 , Edited by admin on Fri Dec 15 15:31:20 UTC 2023
PRIMARY
NCI_THESAURUS
C2603
Created by admin on Fri Dec 15 15:31:20 UTC 2023 , Edited by admin on Fri Dec 15 15:31:20 UTC 2023
PRIMARY
CAS
120011-70-3
Created by admin on Fri Dec 15 15:31:20 UTC 2023 , Edited by admin on Fri Dec 15 15:31:20 UTC 2023
PRIMARY
RXCUI
236559
Created by admin on Fri Dec 15 15:31:20 UTC 2023 , Edited by admin on Fri Dec 15 15:31:20 UTC 2023
PRIMARY RxNorm
EPA CompTox
DTXSID0046698
Created by admin on Fri Dec 15 15:31:20 UTC 2023 , Edited by admin on Fri Dec 15 15:31:20 UTC 2023
PRIMARY
Related Record Type Details
Structure of DONEPEZIL HYDROCHLORIDE MONOHYDRATE
SOLVATE->ANHYDROUS
Structure of DONEPEZIL HYDROCHLORIDE
BASIS OF STRENGTH->SUBSTANCE
ASSAY (HPLC)
USP
Structure of DONEPEZIL
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of 2-((1-BENZYL-1,2,3,4-TETRAHYDROPYRIDIN-4-YL)METHYL)-5,6-DIMETHOXY-2,3-DIHYDRO-1H-INDEN-1-ONE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of DONEPEZILBENZYL CATION
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of DONEPEZILBENZYL BROMIDE
IMPURITY -> PARENT
Procedure 2
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of DEOXYDONEPEZIL
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of 5,6-DIMETHOXY-2-(PYRIDIN-4-YLMETHYL)INDAN-1-ONE
IMPURITY -> PARENT
Structure of DONEPEZIL ALKENE PYRIDINE N-OXIDE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of DESBENZYL DONEPEZIL
IMPURITY -> PARENT
Procedure 2
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of DEHYDRODEOXY DONEPEZIL
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
DONEPEZIL N-OXIDE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of HYDROXYDONEPEZIL
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of 2-((1-BENZYLPIPERIDIN-4-YL)METHYLENE)-5,6-DIMETHOXYINDAN-1-ONE, (E)-
IMPURITY -> PARENT
Structure of 4-((2,3-DIHYDRO-5,6-DIMETHOXY-1-OXO-1H-INDEN-2-YL)METHYL)-1-(PHENYLMETHYL)PYRIDINIUM
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 5,6-DIMETHOXY-1-INDANONE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
Structure of DONEPEZIL
ACTIVE MOIETY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966