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Details

Stereochemistry ABSOLUTE
Molecular Formula C19H20FNO3
Molecular Weight 329.3654
Optical Activity ( - )
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PAROXETINE

SMILES

FC1=CC=C(C=C1)[C@@H]2CCNC[C@H]2COC3=CC=C4OCOC4=C3

InChI

InChIKey=AHOUBRCZNHFOSL-YOEHRIQHSA-N
InChI=1S/C19H20FNO3/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18/h1-6,9,14,17,21H,7-8,10-12H2/t14-,17-/m0/s1

HIDE SMILES / InChI
Molecular Formula C19H20FNO3
Molecular Weight 329.3654
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:31:05 UTC 2023
Edited
by admin
on Fri Dec 15 15:31:05 UTC 2023
Record UNII
41VRH5220H
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PAROXETINE
INN   MART.   MI   USAN   VANDF   WHO-DD  
INN   USAN  
Official Name English
PAROGEN
Common Name English
(-)-TRANS-4-(P-FLUOROPHENYL)-3-((3,4-(METHYLENEDIOXY)PHENOXY)METHYL)PIPERIDINE
Common Name English
paroxetine [INN]
Common Name English
PIPERIDINE, 3-((1,3-BENZODIOXOL-5-YLOXY)METHYL)-4-(4-FLUOROPHENYL)-, (3S-TRANS)-
Systematic Name English
PAROXETINE [VANDF]
Common Name English
MOTIVAN
Common Name English
FROSINOR
Common Name English
(-)-(3S,4R)-4-(P-FLUOROPHENYL)-3-((3,4-METHYLENEDIOXY)PHENOXY)METHYL)PIPERIDINE
Common Name English
(-)3S,4R-PAROXETINE
Common Name English
BESITRAM
Common Name English
ARKETIS
Common Name English
(3S,4R)-3-((1,3-BENZODIOXOL-5-YLOXY)METHYL)-4-(4-FLUOROPHENYL)PIPERIDINE
Systematic Name English
PAROXETINE [MART.]
Common Name English
PAXPAR
Common Name English
CASBOL
Common Name English
DAPAROX
Common Name English
FG-7051
Common Name English
PAROXETINE [USAN]
Common Name English
Paroxetine [WHO-DD]
Common Name English
PAROXETINE [MI]
Common Name English
XETANOR
Common Name English
AROTIN
Common Name English
BRL-29060
Code English
Classification Tree Code System Code
LIVERTOX NBK548306
Created by admin on Fri Dec 15 15:31:05 UTC 2023 , Edited by admin on Fri Dec 15 15:31:05 UTC 2023
NDF-RT N0000000109
Created by admin on Fri Dec 15 15:31:05 UTC 2023 , Edited by admin on Fri Dec 15 15:31:05 UTC 2023
WHO-VATC QN06AB05
Created by admin on Fri Dec 15 15:31:05 UTC 2023 , Edited by admin on Fri Dec 15 15:31:05 UTC 2023
NCI_THESAURUS C94725
Created by admin on Fri Dec 15 15:31:05 UTC 2023 , Edited by admin on Fri Dec 15 15:31:05 UTC 2023
NCI_THESAURUS C265
Created by admin on Fri Dec 15 15:31:05 UTC 2023 , Edited by admin on Fri Dec 15 15:31:05 UTC 2023
NDF-RT N0000175696
Created by admin on Fri Dec 15 15:31:05 UTC 2023 , Edited by admin on Fri Dec 15 15:31:05 UTC 2023
WHO-ATC N06AB05
Created by admin on Fri Dec 15 15:31:05 UTC 2023 , Edited by admin on Fri Dec 15 15:31:05 UTC 2023
Code System Code Type Description
WIKIPEDIA
PAROXETINE
Created by admin on Fri Dec 15 15:31:05 UTC 2023 , Edited by admin on Fri Dec 15 15:31:05 UTC 2023
PRIMARY
EVMPD
SUB09631MIG
Created by admin on Fri Dec 15 15:31:05 UTC 2023 , Edited by admin on Fri Dec 15 15:31:05 UTC 2023
PRIMARY
DAILYMED
41VRH5220H
Created by admin on Fri Dec 15 15:31:05 UTC 2023 , Edited by admin on Fri Dec 15 15:31:05 UTC 2023
PRIMARY
FDA UNII
41VRH5220H
Created by admin on Fri Dec 15 15:31:05 UTC 2023 , Edited by admin on Fri Dec 15 15:31:05 UTC 2023
PRIMARY
MERCK INDEX
m8418
Created by admin on Fri Dec 15 15:31:05 UTC 2023 , Edited by admin on Fri Dec 15 15:31:05 UTC 2023
PRIMARY Merck Index
IUPHAR
4790
Created by admin on Fri Dec 15 15:31:05 UTC 2023 , Edited by admin on Fri Dec 15 15:31:05 UTC 2023
PRIMARY
ChEMBL
CHEMBL490
Created by admin on Fri Dec 15 15:31:05 UTC 2023 , Edited by admin on Fri Dec 15 15:31:05 UTC 2023
PRIMARY
NCI_THESAURUS
C61879
Created by admin on Fri Dec 15 15:31:05 UTC 2023 , Edited by admin on Fri Dec 15 15:31:05 UTC 2023
PRIMARY
LACTMED
Paroxetine
Created by admin on Fri Dec 15 15:31:05 UTC 2023 , Edited by admin on Fri Dec 15 15:31:05 UTC 2023
PRIMARY
INN
4327
Created by admin on Fri Dec 15 15:31:05 UTC 2023 , Edited by admin on Fri Dec 15 15:31:05 UTC 2023
PRIMARY
SMS_ID
100000091962
Created by admin on Fri Dec 15 15:31:05 UTC 2023 , Edited by admin on Fri Dec 15 15:31:05 UTC 2023
PRIMARY
CHEBI
7936
Created by admin on Fri Dec 15 15:31:05 UTC 2023 , Edited by admin on Fri Dec 15 15:31:05 UTC 2023
PRIMARY
DRUG BANK
DB00715
Created by admin on Fri Dec 15 15:31:05 UTC 2023 , Edited by admin on Fri Dec 15 15:31:05 UTC 2023
PRIMARY
EPA CompTox
DTXSID3023425
Created by admin on Fri Dec 15 15:31:05 UTC 2023 , Edited by admin on Fri Dec 15 15:31:05 UTC 2023
PRIMARY
CAS
61869-08-7
Created by admin on Fri Dec 15 15:31:05 UTC 2023 , Edited by admin on Fri Dec 15 15:31:05 UTC 2023
PRIMARY
RXCUI
32937
Created by admin on Fri Dec 15 15:31:05 UTC 2023 , Edited by admin on Fri Dec 15 15:31:05 UTC 2023
PRIMARY RxNorm
PUBCHEM
43815
Created by admin on Fri Dec 15 15:31:05 UTC 2023 , Edited by admin on Fri Dec 15 15:31:05 UTC 2023
PRIMARY
HSDB
7175
Created by admin on Fri Dec 15 15:31:05 UTC 2023 , Edited by admin on Fri Dec 15 15:31:05 UTC 2023
PRIMARY
MESH
D017374
Created by admin on Fri Dec 15 15:31:05 UTC 2023 , Edited by admin on Fri Dec 15 15:31:05 UTC 2023
PRIMARY
DRUG CENTRAL
2068
Created by admin on Fri Dec 15 15:31:05 UTC 2023 , Edited by admin on Fri Dec 15 15:31:05 UTC 2023
PRIMARY
USAN
AA-62
Created by admin on Fri Dec 15 15:31:05 UTC 2023 , Edited by admin on Fri Dec 15 15:31:05 UTC 2023
PRIMARY
Related Record Type Details
Structure of PAROXETINE HYDROCHLORIDE ANHYDROUS
PARENT -> SALT/SOLVATE
Structure of PAROXETINE, (±)-
RACEMATE -> ENANTIOMER
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
CYTOCHROME P450 2D6
METABOLIC ENZYME -> INHIBITOR
STRONG INHIBITOR. Lofexidine exposures were approximately 30% greater with co-administration of paroxetine.
Structure of PAROXETINE MESYLATE
SALT/SOLVATE -> PARENT
Structure of PAROXETINE MALEATE
SALT/SOLVATE -> PARENT
CYTOCHROME P450 2D6
METABOLIC ENZYME -> SUBSTRATE
CYTOCHROME P450 3A4
METABOLIC ENZYME -> INHIBITOR
Structure of CTP-347
LABELED -> NON-LABELED
Structure of PAROXETINE ACETATE
SALT/SOLVATE -> PARENT
Structure of PAROXETINE HYDROCHLORIDE
SALT/SOLVATE -> PARENT
SODIUM-DEPENDENT SEROTONIN TRANSPORTER
TARGET -> INHIBITOR
Related Record Type Details
Structure of PHENOL, 4-((4-(4-FLUOROPHENYL)-3-PIPERIDINYL)METHOXY)-2-METHOXY-, (3S-TRANS)-
METABOLITE INACTIVE -> PARENT
Structure of 4-(((3S,4R)-4-(4-FLUOROPHENYL)-3-PIPERIDINYL)METHOXY)-1,2-BENZENEDIOL
METABOLITE INACTIVE -> PARENT
Structure of PHENOL, 5-((4-(4-FLUOROPHENYL)-3-PIPERIDINYL)METHOXY)-2-METHOXY-, (3S-TRANS)-
METABOLITE INACTIVE -> PARENT
Structure of (3S,4R)-4-(4-FLUOROPHENYL)-3-PIPERIDINEMETHANOL
METABOLITE INACTIVE -> PARENT
Related Record Type Details
Structure of PAROXETINE
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Volume of Distribution PHARMACOKINETIC
Route of Elimination PHARMACOKINETIC EXCRETED UNCHANGED

MAXIMUM TOLERATED DOSE TOXICITY PANIC DISORDER: 75 mg/day (CONTROLLED-RELEASE TABLET)

SOCIAL PHOBIA: 37.5 mg/day (CONTROLLED-RELEASE TABLET)

OBSESSIVE-COMPULSIVE DISORDER: 60 mg/day (FDA DOSAGE) (IMMEDIATE-RELEASE TABLET AND SUSPENSION)

PANIC DISORDER: 60 mg/day (IMMEDIATE-RELEASE TABLET AND SUSPENSION)

MAJOR DEPRESSIVE DISORDER: 62.5 mg/day (CONTROLLED-RELEASE TABLET)

OBSESSIVE-COMPULSIVE DISORDER: 60 -100 mg/day (GUIDELINE DOSAGE) (RAPID METABOLIZERS OR THOSE WITH INADEQUATE RESPONSE AFTER 8 WEEKS)

PROTEIN BINDING PHARMACOKINETIC
Route of Elimination PHARMACOKINETIC EXCRETED UNCHANGED

Tmax PHARMACOKINETIC
Biological Half-life PHARMACOKINETIC
Tmax PHARMACOKINETIC
NIH
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