ONDANSETRON

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C18H19N3O
Molecular Weight	293.363
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ONDANSETRON

Structure Search

SMILES

CN1C2=C(C3=C1C=CC=C3)C(=O)C(CN4C=CN=C4C)CC2

InChI

InChIKey=FELGMEQIXOGIFQ-UHFFFAOYSA-N

InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C18H19N3O
Molecular Weight	293.363
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:13:09 UTC 2023` Edited by `admin` on `Fri Dec 15 19:13:09 UTC 2023`
Record UNII	4AF302ESOS
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ONDANSETRON

Official Name

English

ONDANSETRON [MI]

Common Name

English

(±)-2,3-DIHYDRO-9-METHYL-3-((2-METHYLIMIDAZOL-1-YL)METHYL)CARBAZOL-4(1H)-ONE

Systematic Name

English

A04AA01

Code

English

ONDANSETRON [MART.]

Common Name

English

EUR-1025

Code

English

ondansetron [INN]

Common Name

English

4H-CARBAZOL-4-ONE, 1,2,3,9-TETRAHYDRO-9-METHYL-3-((2-METHYL-1H-IMIDAZOL-1-YL)METHYL)- (±)-

Systematic Name

English

NSC-757870

Code

English

ONDANSETRON [VANDF]

Common Name

English

ONDANSETRON [USP MONOGRAPH]

Common Name

English

ZOFRAN ODT

Brand Name

English

ONDANSETRON [ORANGE BOOK]

Common Name

English

ONDANSETRON [JAN]

Common Name

English

Ondansetron [WHO-DD]

Common Name

English

ONDANSETRON [USP-RS]

Common Name

English

Classification Tree Code System Code

WHO-ESSENTIAL MEDICINES LIST

17.2

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

WHO-ESSENTIAL MEDICINES LIST

8.4

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

LIVERTOX

711

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

NCI_THESAURUS

C267

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

NDF-RT

N0000175818

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

NDF-RT

N0000175817

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

WHO-VATC

QA04AA01

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

WHO-ATC

A04AA01

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

NCI_THESAURUS

C94726

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

FDA ORPHAN DRUG

491115

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

Code System Code Type Description

FDA UNII

4AF302ESOS

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

PRIMARY

MESH

D017294

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

PRIMARY

NSC

757870

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

PRIMARY

DRUG CENTRAL

1992

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

PRIMARY

HSDB

8304

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

PRIMARY

MERCK INDEX

m8213

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

PRIMARY

Merck Index

LACTMED

Ondansetron

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

PRIMARY

INN

5965

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

PRIMARY

WIKIPEDIA

ONDANSETRON

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

PRIMARY

EVMPD

SUB09445MIG

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

PRIMARY

RXCUI

26225

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

PRIMARY

RxNorm

RS_ITEM_NUM

1478571

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

PRIMARY

CAS

99614-02-5

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

SUPERSEDED

PUBCHEM

4595

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

PRIMARY

IUPHAR

2290

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

PRIMARY

EPA CompTox

DTXSID8023393

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

PRIMARY

ChEMBL

CHEMBL46

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

PRIMARY

NCI_THESAURUS

C1119

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

PRIMARY

DRUG BANK

DB00904

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

PRIMARY

DAILYMED

4AF302ESOS

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

PRIMARY

CAS

99614-02-5

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

PRIMARY

SMS_ID

100000092334

Created by admin on Fri Dec 15 19:13:09 UTC 2023 , Edited by admin on Fri Dec 15 19:13:09 UTC 2023

PRIMARY

Related Record Type Details


					O6P326G4LZ

5-HYDROXYTRYPTAMINE RECEPTOR 3

TARGET -> INHIBITOR


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE


					NMH84OZK2B

ONDANSETRON HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:


					4AF302ESOS

BASIS OF STRENGTH->SUBSTANCE

Interaction Type:

ASSAY (HPLC)

Qualification:

USP

Amount:


					LR0F81F33L

ALDEHYDE OXIDASE

METABOLIC ENZYME -> INHIBITOR

Qualification:

IC50

Amount:


					8E4LAA4357

CYTOCHROME P450 2D6

METABOLIC ENZYME -> SUBSTRATE


					EA9HO2Z7V5

5-HYDROXYTRYPTAMINE RECEPTOR 3A

TARGET -> INHIBITOR

Qualification:

IC50

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					22ES734693

MULTIDRUG RESISTANCE PROTEIN 1

TRANSPORTER -> SUBSTRATE

Related Record Type Details


					59D7QNM478

ONDANSETRON 8-SULFATE

METABOLITE INACTIVE -> PARENT


					33NAL20TBU

ONDANSETRON 8-D-GLUCURONIDE

METABOLITE -> PARENT


					20UA9420EZ

8-HYDROXYONDANSETRON

METABOLITE ACTIVE -> PARENT

Comments:

Multiple P450 isoforms; Not found in plasma at concentrations likely to significantly contribute to the biological activity of ondansetron

Amount:


					31S56S12GI

N-DESMETHYLONDANSETRON

METABOLITE -> PARENT

Comments:

multiple CYP isoforms


					FA93J3KSIH

7-HYDROXYONDANSETRON

METABOLITE -> PARENT

Comments:

Multiple CYP isoforms


					3C5DG1282Q

6-HYDROXYONDANSETRON

METABOLITE -> PARENT

Comments:

Multiple CYP isoenzymes

Related Record Type Details


					098F00IT8F

1,2,3,9-TETRAHYDRO-9-METHYL-3-METHYLENE-4H-CARBAZOL-4-ONE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:

Related Record Type Details


					4AF302ESOS

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC				Children <15 Years PHARMACOKINETIC