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Details

Stereochemistry ACHIRAL
Molecular Formula C14H20N2O3
Molecular Weight 264.3202
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of VORINOSTAT

SMILES

ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1

InChI

InChIKey=WAEXFXRVDQXREF-UHFFFAOYSA-N
InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)

HIDE SMILES / InChI
Molecular Formula C14H20N2O3
Molecular Weight 264.3202
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Sat Dec 16 15:47:37 UTC 2023
Edited
by admin
on Sat Dec 16 15:47:37 UTC 2023
Record UNII
58IFB293JI
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
VORINOSTAT
INN   JAN   MART.   MI   ORANGE BOOK   USAN   VANDF   WHO-DD  
INN   USAN  
Official Name English
VORINOSTAT [MI]
Common Name English
NSC-759852
Code English
VORINOSTAT [ORANGE BOOK]
Common Name English
NSC-701852
Code English
N-HYDROXY-N'-PHENYLOCTANEDIAMIDE
Systematic Name English
NSC-748799
Code English
ZOLINZA
Brand Name English
MK0683
Code English
VORINOSTAT [MART.]
Common Name English
MK-0683
Code English
VORINOSTAT [USAN]
Common Name English
OCTANEDIAMIDE, N-HYDROXY-N'-PHENYL-
Systematic Name English
vorinostat [INN]
Common Name English
Vorinostat [WHO-DD]
Common Name English
SUBEROYLANILIDE HYDROXAMIC ACID
Common Name English
VORINOSTAT [JAN]
Common Name English
VORINOSTAT [VANDF]
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 177203
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
WHO-VATC QL01XX38
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
EU-Orphan Drug EU/3/11/854
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
LIVERTOX NBK548004
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
NCI_THESAURUS C1946
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
NDF-RT N0000175588
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
FDA ORPHAN DRUG 540116
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
WHO-ATC L01XX38
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
NDF-RT N0000175071
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
FDA ORPHAN DRUG 174203
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
FDA ORPHAN DRUG 169503
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
Code System Code Type Description
ChEMBL
CHEMBL98
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
PRIMARY
SMS_ID
100000088823
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
PRIMARY
DRUG CENTRAL
4124
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
PRIMARY
CAS
149647-78-9
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
PRIMARY
MERCK INDEX
m11502
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
PRIMARY Merck Index
HSDB
7930
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
PRIMARY
PUBCHEM
5311
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
PRIMARY
RXCUI
194337
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
PRIMARY RxNorm
NSC
759852
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
PRIMARY
FDA UNII
58IFB293JI
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
PRIMARY
DAILYMED
58IFB293JI
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
PRIMARY
MESH
C111237
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
PRIMARY
INN
8661
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
PRIMARY
NCI_THESAURUS
C1796
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
PRIMARY
CHEBI
45716
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
PRIMARY
IUPHAR
6852
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
PRIMARY
NSC
701852
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
PRIMARY
NSC
748799
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
PRIMARY
WIKIPEDIA
VORINOSTAT
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
PRIMARY
USAN
RR-09
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
PRIMARY
EPA CompTox
DTXSID6041133
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
PRIMARY
EVMPD
SUB23356
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
PRIMARY
DRUG BANK
DB02546
Created by admin on Sat Dec 16 15:47:41 UTC 2023 , Edited by admin on Sat Dec 16 15:47:41 UTC 2023
PRIMARY
Related Record Type Details
HISTONE DEACETYLASE 1
TARGET -> INHIBITOR
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HISTONE DEACETYLASE 6
TARGET -> INHIBITOR
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URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A1
METABOLIC ENZYME -> SUBSTRATE
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TARGET -> INHIBITOR
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Structure of VORINOSTAT
EXCRETED UNCHANGED
AMOUNT EXCRETED
URINE
HISTONE DEACETYLASE 2
TARGET -> INHIBITOR
BINDING
IC50
HISTONE DEACETYLASE 8
TARGET->WEAK INHIBITOR
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URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 2B17
METABOLIC ENZYME -> SUBSTRATE
HISTONE DEACETYLASE 10
TARGET -> INHIBITOR
Enzymatic Inhibition
IC50
HISTONE DEACETYLASE 5
TARGET->WEAK INHIBITOR
BINDING
IC50
HISTONE DEACETYLASE 8
TARGET -> INHIBITOR
Enzymatic Inhibition
IC50
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A7
METABOLIC ENZYME -> SUBSTRATE
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A9
METABOLIC ENZYME -> SUBSTRATE
HISTONE DEACETYLASE 11
TARGET -> INHIBITOR
Enzymatic Inhibition
IC50
HISTONE DEACETYLASE 3
TARGET -> INHIBITOR
Enzymatic Inhibition
IC50
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A3
METABOLIC ENZYME -> SUBSTRATE
HISTONE DEACETYLASE 2
TARGET -> INHIBITOR
Enzymatic Inhibition
IC50
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
TARGET ORGANISM->INHIBITOR
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A8
METABOLIC ENZYME -> SUBSTRATE
HISTONE DEACETYLASE 3
TARGET -> INHIBITOR
BINDING
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URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 2B7
METABOLIC ENZYME -> SUBSTRATE
HISTONE DEACETYLASE 1
TARGET -> INHIBITOR
Enzymatic Inhibition
IC50
Related Record Type Details
Structure of N-PHENYLOCTANEDIAMIDE
METABOLITE -> PARENT
Structure of SUBERANILIC ACID
METABOLITE -> PARENT
Structure of 4-AMINOPHENYL SULFATE
METABOLITE -> PARENT
Structure of ACETAMINOPHEN SULFATE
METABOLITE -> PARENT
Structure of 2-AMINOPHENYL SULFATE
METABOLITE -> PARENT
Structure of SUCCINANILIC ACID
METABOLITE INACTIVE -> PARENT
PLASMA
Structure of ADIPANILIC ACID
METABOLITE -> PARENT
Structure of VORINOSTAT-O-GLUCURONIDE
METABOLITE INACTIVE -> PARENT
MAJOR
URINE
Structure of ACETANILIDE
METABOLITE -> PARENT
Structure of SUCCINANILIC ACID
METABOLITE INACTIVE -> PARENT
URINE
Structure of ACETAMINOPHEN
METABOLITE -> PARENT
Related Record Type Details
Structure of VORINOSTAT
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
blood-to-plasma ratio PHARMACOKINETIC
Tmax PHARMACOKINETIC FED CONDITION

HIGH-FAT MEAL

Volume of Distribution PHARMACOKINETIC INTRAVENOUS ADMINISTRATION

DOSE

Biological Half-life PHARMACOKINETIC
Tmax PHARMACOKINETIC ORAL ADMINISTRATION

FASTED CONDITION

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