PALONOSETRON

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C19H24N2O
Molecular Weight	296.4067
Optical Activity	( - )
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of PALONOSETRON

Structure Search

SMILES

[H][C@]12CCCC3=C1C(=CC=C3)C(=O)N(C2)[C@@H]4CN5CCC4CC5

InChI

InChIKey=CPZBLNMUGSZIPR-NVXWUHKLSA-N

InChI=1S/C19H24N2O/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20/h2,4,6,13,15,17H,1,3,5,7-12H2/t15-,17-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C19H24N2O
Molecular Weight	296.4067
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:09:36 UTC 2023` Edited by `admin` on `Sat Dec 16 17:09:36 UTC 2023`
Record UNII	5D06587D6R
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PALONOSETRON

Official Name

English

NSC-743769

Code

English

PALONOSETRON, (3AS, 3S)-

Common Name

English

Palonosetron [WHO-DD]

Common Name

English

PALONOSETRON [VANDF]

Common Name

English

PALONOSETRON [MI]

Common Name

English

palonosetron [INN]

Common Name

English

1H-BENZ(DE)ISOQUINOLIN-1-ONE, 2-(3S)-1-AZABICYCLO(2.2.2)OCT-3-YL-2,3,3A,4,5,6-HEXAHYDRO-, (3AS)-

Systematic Name

English

(-)-PALONOSETRON

Common Name

English

Classification Tree Code System Code

EMA ASSESSMENT REPORTS

PALONOSETRON ACCORD (AUTHORIZED: CANCER, NAUSEA, VOMITING)

Created by admin on Sat Dec 16 17:09:37 UTC 2023 , Edited by admin on Sat Dec 16 17:09:37 UTC 2023

NDF-RT

N0000175818

Created by admin on Sat Dec 16 17:09:37 UTC 2023 , Edited by admin on Sat Dec 16 17:09:37 UTC 2023

NCI_THESAURUS

C267

Created by admin on Sat Dec 16 17:09:37 UTC 2023 , Edited by admin on Sat Dec 16 17:09:37 UTC 2023

WHO-VATC

QA04AA05

Created by admin on Sat Dec 16 17:09:37 UTC 2023 , Edited by admin on Sat Dec 16 17:09:37 UTC 2023

NDF-RT

N0000175817

Created by admin on Sat Dec 16 17:09:37 UTC 2023 , Edited by admin on Sat Dec 16 17:09:37 UTC 2023

WHO-ATC

A04AA05

Created by admin on Sat Dec 16 17:09:37 UTC 2023 , Edited by admin on Sat Dec 16 17:09:37 UTC 2023

WHO-ATC

A04AA55

Created by admin on Sat Dec 16 17:09:37 UTC 2023 , Edited by admin on Sat Dec 16 17:09:37 UTC 2023

LIVERTOX

733

Created by admin on Sat Dec 16 17:09:37 UTC 2023 , Edited by admin on Sat Dec 16 17:09:37 UTC 2023

NCI_THESAURUS

C94726

Created by admin on Sat Dec 16 17:09:37 UTC 2023 , Edited by admin on Sat Dec 16 17:09:37 UTC 2023

Code System Code Type Description

IUPHAR

7486

Created by admin on Sat Dec 16 17:09:37 UTC 2023 , Edited by admin on Sat Dec 16 17:09:37 UTC 2023

PRIMARY

CHEBI

85161

Created by admin on Sat Dec 16 17:09:37 UTC 2023 , Edited by admin on Sat Dec 16 17:09:37 UTC 2023

PRIMARY

PUBCHEM

6337614

Created by admin on Sat Dec 16 17:09:37 UTC 2023 , Edited by admin on Sat Dec 16 17:09:37 UTC 2023

PRIMARY

FDA UNII

5D06587D6R

Created by admin on Sat Dec 16 17:09:37 UTC 2023 , Edited by admin on Sat Dec 16 17:09:37 UTC 2023

PRIMARY

INN

7407

Created by admin on Sat Dec 16 17:09:37 UTC 2023 , Edited by admin on Sat Dec 16 17:09:37 UTC 2023

PRIMARY

EVMPD

SUB09593MIG

Created by admin on Sat Dec 16 17:09:37 UTC 2023 , Edited by admin on Sat Dec 16 17:09:37 UTC 2023

PRIMARY

CAS

135729-61-2

Created by admin on Sat Dec 16 17:09:37 UTC 2023 , Edited by admin on Sat Dec 16 17:09:37 UTC 2023

PRIMARY

DRUG CENTRAL

2046

Created by admin on Sat Dec 16 17:09:37 UTC 2023 , Edited by admin on Sat Dec 16 17:09:37 UTC 2023

PRIMARY

WIKIPEDIA

PALONOSETRON

Created by admin on Sat Dec 16 17:09:37 UTC 2023 , Edited by admin on Sat Dec 16 17:09:37 UTC 2023

PRIMARY

MESH

C083418

Created by admin on Sat Dec 16 17:09:37 UTC 2023 , Edited by admin on Sat Dec 16 17:09:37 UTC 2023

PRIMARY

NCI_THESAURUS

C61874

Created by admin on Sat Dec 16 17:09:37 UTC 2023 , Edited by admin on Sat Dec 16 17:09:37 UTC 2023

PRIMARY

DAILYMED

5D06587D6R

Created by admin on Sat Dec 16 17:09:37 UTC 2023 , Edited by admin on Sat Dec 16 17:09:37 UTC 2023

PRIMARY

DRUG BANK

DB00377

Created by admin on Sat Dec 16 17:09:37 UTC 2023 , Edited by admin on Sat Dec 16 17:09:37 UTC 2023

PRIMARY

ChEMBL

CHEMBL1189679

Created by admin on Sat Dec 16 17:09:37 UTC 2023 , Edited by admin on Sat Dec 16 17:09:37 UTC 2023

PRIMARY

SMS_ID

100000085493

Created by admin on Sat Dec 16 17:09:37 UTC 2023 , Edited by admin on Sat Dec 16 17:09:37 UTC 2023

PRIMARY

MERCK INDEX

m8368

Created by admin on Sat Dec 16 17:09:37 UTC 2023 , Edited by admin on Sat Dec 16 17:09:37 UTC 2023

PRIMARY

NSC

743769

Created by admin on Sat Dec 16 17:09:37 UTC 2023 , Edited by admin on Sat Dec 16 17:09:37 UTC 2023

PRIMARY

RXCUI

70561

Created by admin on Sat Dec 16 17:09:37 UTC 2023 , Edited by admin on Sat Dec 16 17:09:37 UTC 2023

PRIMARY

RxNorm

Related Record Type Details


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE

Amount:


					4KK4DR3MIN

5-HYDROXYTRYPTAMINE RECEPTOR 3B

TARGET -> INHIBITOR

Interaction Type:

BINDING

Amount:


					23310D4I19

PALONOSETRON HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:


					8E4LAA4357

CYTOCHROME P450 2D6

METABOLIC ENZYME -> SUBSTRATE

Interaction Type:

MAJOR

Amount:


					EA9HO2Z7V5

5-HYDROXYTRYPTAMINE RECEPTOR 3A

TARGET -> INHIBITOR

Interaction Type:

BINDING

Amount:


					VK4SQL11C0

CYTOCHROME P450 1A2

METABOLIC ENZYME -> SUBSTRATE

Amount:


					5D06587D6R

EXCRETED UNCHANGED

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					O6P326G4LZ

5-HYDROXYTRYPTAMINE RECEPTOR 3

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					MIV4QW9F6J

PALONOSETRON N-OXIDE

METABOLITE LESS ACTIVE -> PARENT

Comments:

The metabolite has less than 1% of the 5-HT3 receptor antagonist activity of palonosetron.

Amount:


					G5GT4PN0X7

6S-HYDROXY-PALONOSETRON

METABOLITE LESS ACTIVE -> PARENT

Comments:

The metabolite has less than 1% of the 5-HT3 receptor antagonist activity of palonosetron.

Amount:

Related Record Type Details


					5D06587D6R

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Tmax	PHARMACOKINETIC				intravenous administration

Biological Half-life	PHARMACOKINETIC				Population: Children PHARMACOKINETIC

Volume of Distribution	PHARMACOKINETIC