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Details

Stereochemistry ACHIRAL
Molecular Formula C22H23ClN2O2
Molecular Weight 382.883
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LORATADINE

SMILES

CCOC(=O)N1CCC(CC1)=C2C3=C(CCC4=C2N=CC=C4)C=C(Cl)C=C3

InChI

InChIKey=JCCNYMKQOSZNPW-UHFFFAOYSA-N
InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3

HIDE SMILES / InChI
Molecular Formula C22H23ClN2O2
Molecular Weight 382.883
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:33:07 UTC 2023
Edited
by admin
on Fri Dec 15 15:33:07 UTC 2023
Record UNII
7AJO3BO7QN
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LORATADINE
EP   HSDB   INN   JAN   MART.   MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF   WHO-DD  
INN   USAN  
Official Name English
SCH-29851
Code English
Loratadine [WHO-DD]
Common Name English
1-PIPERIDINECARBOXYLIC ACID, 4-(8-CHLORO-5,6-DIHYDRO-11H-BENZO(5,6)CYCLOHEPTA(1,2-B)PYRIDIN-11-YLIDENE)-, ETHYL ESTER
Common Name English
LORATADINE [MART.]
Common Name English
LORATADINE [USP MONOGRAPH]
Common Name English
LORATADINE [EP MONOGRAPH]
Common Name English
LORATADINE [HSDB]
Common Name English
LORATADINE [MI]
Common Name English
LORATADINE COMPONENT OF CLARITIN-D
Common Name English
BAY76-2211
Code English
LORATADINE [USP-RS]
Common Name English
SCH 29851
Code English
LORATADINE [USAN]
Common Name English
ALAVERT
Brand Name English
CLARITIN-D COMPONENT LORATADINE
Common Name English
loratadine [INN]
Common Name English
NSC-758628
Code English
LORATADINE [ORANGE BOOK]
Common Name English
LORATADINE [VANDF]
Common Name English
LORATADINE [JAN]
Common Name English
CLARITIN
Brand Name English
LORATADINE [EP IMPURITY]
Common Name English
Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate
Systematic Name English
Classification Tree Code System Code
WHO-ATC R06AX13
Created by admin on Fri Dec 15 15:33:07 UTC 2023 , Edited by admin on Fri Dec 15 15:33:07 UTC 2023
NCI_THESAURUS C29578
Created by admin on Fri Dec 15 15:33:07 UTC 2023 , Edited by admin on Fri Dec 15 15:33:07 UTC 2023
WHO-VATC QR06AX13
Created by admin on Fri Dec 15 15:33:07 UTC 2023 , Edited by admin on Fri Dec 15 15:33:07 UTC 2023
LIVERTOX NBK548831
Created by admin on Fri Dec 15 15:33:07 UTC 2023 , Edited by admin on Fri Dec 15 15:33:07 UTC 2023
Code System Code Type Description
EPA CompTox
DTXSID2023224
Created by admin on Fri Dec 15 15:33:07 UTC 2023 , Edited by admin on Fri Dec 15 15:33:07 UTC 2023
PRIMARY
IUPHAR
7216
Created by admin on Fri Dec 15 15:33:07 UTC 2023 , Edited by admin on Fri Dec 15 15:33:07 UTC 2023
PRIMARY
NSC
758628
Created by admin on Fri Dec 15 15:33:07 UTC 2023 , Edited by admin on Fri Dec 15 15:33:07 UTC 2023
PRIMARY
SMS_ID
100000092179
Created by admin on Fri Dec 15 15:33:07 UTC 2023 , Edited by admin on Fri Dec 15 15:33:07 UTC 2023
PRIMARY
INN
5864
Created by admin on Fri Dec 15 15:33:07 UTC 2023 , Edited by admin on Fri Dec 15 15:33:07 UTC 2023
PRIMARY
CAS
79794-75-5
Created by admin on Fri Dec 15 15:33:07 UTC 2023 , Edited by admin on Fri Dec 15 15:33:07 UTC 2023
PRIMARY
RS_ITEM_NUM
1370270
Created by admin on Fri Dec 15 15:33:07 UTC 2023 , Edited by admin on Fri Dec 15 15:33:07 UTC 2023
PRIMARY
PUBCHEM
3957
Created by admin on Fri Dec 15 15:33:07 UTC 2023 , Edited by admin on Fri Dec 15 15:33:07 UTC 2023
PRIMARY
MERCK INDEX
m6905
Created by admin on Fri Dec 15 15:33:07 UTC 2023 , Edited by admin on Fri Dec 15 15:33:07 UTC 2023
PRIMARY Merck Index
DRUG CENTRAL
1605
Created by admin on Fri Dec 15 15:33:07 UTC 2023 , Edited by admin on Fri Dec 15 15:33:07 UTC 2023
PRIMARY
MESH
D017336
Created by admin on Fri Dec 15 15:33:07 UTC 2023 , Edited by admin on Fri Dec 15 15:33:07 UTC 2023
PRIMARY
LACTMED
Loratadine
Created by admin on Fri Dec 15 15:33:07 UTC 2023 , Edited by admin on Fri Dec 15 15:33:07 UTC 2023
PRIMARY
FDA UNII
7AJO3BO7QN
Created by admin on Fri Dec 15 15:33:07 UTC 2023 , Edited by admin on Fri Dec 15 15:33:07 UTC 2023
PRIMARY
EVMPD
SUB08581MIG
Created by admin on Fri Dec 15 15:33:07 UTC 2023 , Edited by admin on Fri Dec 15 15:33:07 UTC 2023
PRIMARY
HSDB
3578
Created by admin on Fri Dec 15 15:33:07 UTC 2023 , Edited by admin on Fri Dec 15 15:33:07 UTC 2023
PRIMARY
USAN
W-119
Created by admin on Fri Dec 15 15:33:07 UTC 2023 , Edited by admin on Fri Dec 15 15:33:07 UTC 2023
PRIMARY
RXCUI
28889
Created by admin on Fri Dec 15 15:33:07 UTC 2023 , Edited by admin on Fri Dec 15 15:33:07 UTC 2023
PRIMARY RxNorm
ChEMBL
CHEMBL998
Created by admin on Fri Dec 15 15:33:07 UTC 2023 , Edited by admin on Fri Dec 15 15:33:07 UTC 2023
PRIMARY
DAILYMED
7AJO3BO7QN
Created by admin on Fri Dec 15 15:33:07 UTC 2023 , Edited by admin on Fri Dec 15 15:33:07 UTC 2023
PRIMARY
DRUG BANK
DB00455
Created by admin on Fri Dec 15 15:33:07 UTC 2023 , Edited by admin on Fri Dec 15 15:33:07 UTC 2023
PRIMARY
WIKIPEDIA
LORATADINE
Created by admin on Fri Dec 15 15:33:07 UTC 2023 , Edited by admin on Fri Dec 15 15:33:07 UTC 2023
PRIMARY
NCI_THESAURUS
C29162
Created by admin on Fri Dec 15 15:33:07 UTC 2023 , Edited by admin on Fri Dec 15 15:33:07 UTC 2023
PRIMARY
Related Record Type Details
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
ALDEHYDE OXIDASE
METABOLIC ENZYME -> INHIBITOR
IC50
HISTAMINE H1 RECEPTOR
TARGET -> INHIBITOR
Structure of LORATADINE
BASIS OF STRENGTH->SUBSTANCE
ASSAY (TITRATION)
EP
Structure of LORATADINE HYDROCHLORIDE
PARENT->INNOVATOR
Structure of LORATADINE
BASIS OF STRENGTH->SUBSTANCE
ASSAY (HPLC)
USP
Related Record Type Details
Structure of Desloratadine
METABOLITE ACTIVE -> PARENT
Structure of Desloratadine
METABOLITE ACTIVE -> PARENT
MAJOR
Related Record Type Details
Structure of 11-HYDROXY DIHYDRO LORATADINE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of 4-HYDROXYMETHYL LORATADINE
IMPURITY -> PARENT
Structure of N-METHYLDESLORATADINE
IMPURITY -> PARENT
UNSPECIFIED
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of N-METHYLDESLORATADINE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of ISOLORATADINE
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 1.9
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of Desloratadine
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 4,8-DICHLORO-5,6-DIHYDRO-11H-BENZO(5,6)CYCLOHEPTA(1,2-B)PYRIDIN-11-ONE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of 11-FLUORO DIHYDROLORATADINE
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 1.6
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 8-CHLORO-5,6-DIHYDRO-11H-BENZO(5,6)CYCLOHEPTA(1,2-B)PYRIDIN-11-ONE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of Desloratadine
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of 2-HYDROXYMETHYL LORATADINE
IMPURITY -> PARENT
Structure of Desloratadine
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of 11-FLUORO DIHYDROLORATADINE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of ETHYL 4-OXO-1-PIPERIDINECARBOXYLATE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (GC)
EP
Structure of 4-CHLOROLORATADINE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Related Record Type Details
Structure of LORATADINE
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC
NIH
NCATS
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