U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C19H19ClN2
Molecular Weight 310.821
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Desloratadine

SMILES

ClC1=CC2=C(C=C1)C(=C3CCNCC3)C4=C(CC2)C=CC=N4

InChI

InChIKey=JAUOIFJMECXRGI-UHFFFAOYSA-N
InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2

HIDE SMILES / InChI
Molecular Formula C19H19ClN2
Molecular Weight 310.821
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Sat Dec 16 15:51:37 UTC 2023
Edited
by admin
on Sat Dec 16 15:51:37 UTC 2023
Record UNII
FVF865388R
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Desloratadine
EMA EPAR   INN   MART.   MI   ORANGE BOOK   USAN   VANDF   WHO-DD  
USAN   INN  
Official Name English
8-Chloro-5,6-dihydro-11-(piperidin-4-ylidene)-11H-benzo[5,6]cyclohepta[1,2-b]pyridine)
Systematic Name English
DESLORATADINE RATIOPHARM (AUTHORIZED: RHINITIS, URTICARIA)
Brand Name English
DESLORATADINE RATIOPHARM
Brand Name English
DENOSIN
Brand Name English
desloratadine [INN]
Common Name English
5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 8-chloro-6,11-dihydro-11-(4-piperidinylidene)-
Systematic Name English
DASSELTA
Brand Name English
NSC-759824
Code English
DESLORATADINE [MART.]
Common Name English
LORATADINE RELATED COMPOUND A [USP IMPURITY]
Common Name English
NEOCLARITYN
Brand Name English
DESLORATADINE ACTAVIS (AUTHORIZED: RHINITIS, URTICARIA)
Brand Name English
DESLORATADINE [MI]
Common Name English
DESLORATADINE [VANDF]
Common Name English
DESLORATADINE [USP-RS]
Common Name English
RUPATADINE FUMARATE IMPURITY B [EP IMPURITY]
Common Name English
DESLORATADINE [USP MONOGRAPH]
Common Name English
CLARINEX
Brand Name English
DESCARBOETHOXYLORATADINE
Common Name English
DESLORATADINE ACTAVIS
Brand Name English
DESLORATADINE TEVA (AUTHORIZED: RHINITIS, URTICARIA)
Brand Name English
DESLORATADINE [ORANGE BOOK]
Common Name English
CLARINEX-D COMPONENT DESLORATADINE
Common Name English
OPULIS
Brand Name English
SCH-34117
Code English
AZOMYR
Brand Name English
ALLEX
Brand Name English
Desloratadine [WHO-DD]
Common Name English
DESLORATADINE TEVA
Brand Name English
LORATADINE IMPURITY D [EP IMPURITY]
Common Name English
AERIUS
Brand Name English
DESLORATADINE [JAN]
Common Name English
LORATADINE RELATED COMPOUND A [USP-RS]
Common Name English
DESLORATADINE [EMA EPAR]
Common Name English
DESLORATADINE [EP MONOGRAPH]
Common Name English
DESLORATADINE [USAN]
Common Name English
DESLORATADINE COMPONENT OF CLARINEX-D
Common Name English
Classification Tree Code System Code
EMA ASSESSMENT REPORTS DESLORATADINE TEVA (AUTHORIZED: RHINITIS, ALLERGIC, SEASONAL)
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
LIVERTOX NBK548831
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
WHO-VATC QR06AX27
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
EMA ASSESSMENT REPORTS OPULIS (WITHDRAWN: RHINITIS, URTICARIA)
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
NCI_THESAURUS C29578
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
NDF-RT N0000175587
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
EMA ASSESSMENT REPORTS ALLEX(WITHDRAWN: RHINITIS, ALLERGIC, SEASONAL)
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
EMA ASSESSMENT REPORTS DASSELTA (AUTHORIZED: RHINITIS, ALLERGIC, SEASONAL)
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
EMA ASSESSMENT REPORTS DESLORATADINE RATIOPHARM (AUTHORIZED: RHINITIS, ALLERGIC, SEASONAL)
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
EMA ASSESSMENT REPORTS DESLORATADINE ACTAVIS (AUTHORIZED: RHINITIS, URTICARIA)
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
EMA ASSESSMENT REPORTS AZOMYR (AUTHORIZED: RHINITIS, ALLERGIC, SEASONAL)
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
WHO-ATC R06AX27
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
EMA ASSESSMENT REPORTS AERINAZE (AUTHORIZED: RHINITIS)
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
EMA ASSESSMENT REPORTS AERIUS(AUTHORIZED: RHINITIS, ALLERGIC, SEASONAL)
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
EMA ASSESSMENT REPORTS NEOCLARITYN (AUTHORIZED: RHINITIS, URTICARIA)
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
NDF-RT N0000000190
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
Code System Code Type Description
ChEMBL
CHEMBL1172
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
PRIMARY
DRUG BANK
DB00967
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
PRIMARY
RS_ITEM_NUM
1370280
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
ALTERNATIVE
MESH
C121345
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
PRIMARY
CHEBI
291342
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
PRIMARY
INN
7817
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
PRIMARY
RXCUI
275635
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
PRIMARY RxNorm
SMS_ID
100000089395
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
PRIMARY
EPA CompTox
DTXSID1044196
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
PRIMARY
LACTMED
Desloratadine
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
PRIMARY
NCI_THESAURUS
C47474
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
PRIMARY
NSC
759824
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
PRIMARY
PUBCHEM
124087
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
PRIMARY
USAN
KK-46
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
PRIMARY
DRUG CENTRAL
814
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
PRIMARY
FDA UNII
FVF865388R
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
PRIMARY
DAILYMED
FVF865388R
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
PRIMARY
WIKIPEDIA
Desloratadine
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
PRIMARY
RS_ITEM_NUM
1173042
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
PRIMARY
IUPHAR
7157
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
PRIMARY
MERCK INDEX
m4193
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
PRIMARY Merck Index
EVMPD
SUB01596MIG
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
PRIMARY
CAS
100643-71-8
Created by admin on Sat Dec 16 15:51:41 UTC 2023 , Edited by admin on Sat Dec 16 15:51:41 UTC 2023
PRIMARY
Related Record Type Details
CYTOCHROME P450 3A4
METABOLIC ENZYME -> SUBSTRATE
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A3
METABOLIC ENZYME -> SUBSTRATE
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 2B10
TRANSPORTER -> INHIBITOR
Ki
CYTOCHROME P450 2C9
METABOLIC ENZYME -> NON-INHIBITOR
CYTOCHROME P450 2C8
METABOLIC ENZYME -> NON-INHIBITOR
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
HISTAMINE H1 RECEPTOR
TARGET -> INHIBITOR
Desloratadine bound to membranes expressing the recombinant human histamine H1 receptor in Chinese hamster ovary cells (CHO-H1).
Kd
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
CYTOCHROME P450 2C19
METABOLIC ENZYME -> NON-INHIBITOR
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 2B10
METABOLIC ENZYME -> SUBSTRATE
CYTOCHROME P450 3A4
METABOLIC ENZYME -> INHIBITOR
WEAK
CYTOCHROME P450 2C19
METABOLIC ENZYME -> SUBSTRATE
CYTOCHROME P450 2D6
METABOLIC ENZYME -> SUBSTRATE
Structure of DESLORATADINE HEMISULFATE
SALT/SOLVATE -> PARENT
CYTOCHROME P450 2B6
METABOLIC ENZYME -> INHIBITOR
WEAK
HISTAMINE H1 RECEPTOR
TARGET -> INHIBITOR
Kd
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A1
METABOLIC ENZYME -> SUBSTRATE
Structure of DESLORATADINE CITRATE DISODIUM
SALT/SOLVATE -> PARENT
CYTOCHROME P450 2C8
METABOLIC ENZYME -> SUBSTRATE
OCT-2
TRANSPORTER -> INHIBITOR
CYTOCHROME P450 2D6
METABOLIC ENZYME -> INHIBITOR
WEAK
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 2B15
METABOLIC ENZYME -> SUBSTRATE
CYTOCHROME P450 1A2
METABOLIC ENZYME -> NON-INHIBITOR
Related Record Type Details
Structure of 6-HYDROXYDESLORATADINE
METABOLITE -> PARENT
IN VITRO
Structure of 5-HYDROXYDESLORATADINE
METABOLITE -> PARENT
IN VITRO
Structure of LORATADINE
PARENT -> METABOLITE ACTIVE
MAJOR
Structure of 3-HYDROXYDESLORATADINE O-GLUCURONIDE
METABOLITE -> PARENT
IN VITRO
Related Record Type Details
Structure of DECHLORO DESLORATADINE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of 5H-BENZO(5,6)CYCLOHEPTA(1,2-B)PYRIDINE, 8-CHLORO-6,11-DIHYDRO-11-(1,2,3,6-TETRAHYDRO-4-PYRIDINYL)-
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of LORATADINE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of DEHYDRO DESLORATADINE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of FLUORODESLORATADINE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of LORATADINE
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of LORATADINE
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of DESLORATADINE RELATED COMPOUND F [USP-RS]
IMPURITY -> PARENT
Structure of 8-BROMO-DESLORATADINE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of RUPATADINE FUMARATE
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
Structure of Desloratadine
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Tmax PHARMACOKINETIC DOSE

ONCE DAILY

ORAL ADMINISTRATION

Biological Half-life PHARMACOKINETIC
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966