ALFUZOSIN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H27N5O4
Molecular Weight	389.4488
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ALFUZOSIN

Structure Search

SMILES

COC1=CC2=NC(=NC(N)=C2C=C1OC)N(C)CCCNC(=O)C3CCCO3

InChI

InChIKey=WNMJYKCGWZFFKR-UHFFFAOYSA-N

InChI=1S/C19H27N5O4/c1-24(8-5-7-21-18(25)14-6-4-9-28-14)19-22-13-11-16(27-3)15(26-2)10-12(13)17(20)23-19/h10-11,14H,4-9H2,1-3H3,(H,21,25)(H2,20,22,23)

HIDE SMILES / InChI

Molecular Formula	C19H27N5O4
Molecular Weight	389.4488
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:16:53 UTC 2023` Edited by `admin` on `Sat Dec 16 17:16:53 UTC 2023`
Record UNII	90347YTW5F
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ALFUZOSIN

Official Name

English

ALFUZOSIN [VANDF]

Common Name

English

XATRAL

Brand Name

English

ALFUZOSIN [HSDB]

Common Name

English

2-FURANCARBOXAMIDE, (±)-N-(3-((4-AMINO-6,7-DIMETHOXY-2-QUINAZOLINYL)METHYLAMINO)PROPYL)TETRAHYDRO-

Systematic Name

English

alfuzosin [INN]

Common Name

English

ALFUZOSIN [MI]

Common Name

English

Alfuzosin [WHO-DD]

Common Name

English

(±)-N-(3-((4-AMINO-6,7-DIMETHOXYQUINAZOLIN-2-YL)(METHYL)AMINO)PROPYL)TETRAHYDROFURAN-2-CARBOXAMIDE

Systematic Name

English

NSC-760065

Code

English

Classification Tree Code System Code

WHO-ATC

G04CA51

Created by admin on Sat Dec 16 17:16:56 UTC 2023 , Edited by admin on Sat Dec 16 17:16:56 UTC 2023

WHO-VATC

QG04CA51

Created by admin on Sat Dec 16 17:16:56 UTC 2023 , Edited by admin on Sat Dec 16 17:16:56 UTC 2023

WHO-VATC

QG04CA01

Created by admin on Sat Dec 16 17:16:56 UTC 2023 , Edited by admin on Sat Dec 16 17:16:56 UTC 2023

LIVERTOX

NBK548748

Created by admin on Sat Dec 16 17:16:56 UTC 2023 , Edited by admin on Sat Dec 16 17:16:56 UTC 2023

NDF-RT

N0000175553

Created by admin on Sat Dec 16 17:16:56 UTC 2023 , Edited by admin on Sat Dec 16 17:16:56 UTC 2023

NDF-RT

N0000000099

Created by admin on Sat Dec 16 17:16:56 UTC 2023 , Edited by admin on Sat Dec 16 17:16:56 UTC 2023

NCI_THESAURUS

C29713

Created by admin on Sat Dec 16 17:16:56 UTC 2023 , Edited by admin on Sat Dec 16 17:16:56 UTC 2023

WHO-ATC

G04CA01

Created by admin on Sat Dec 16 17:16:56 UTC 2023 , Edited by admin on Sat Dec 16 17:16:56 UTC 2023

Code System Code Type Description

NSC

760065

Created by admin on Sat Dec 16 17:16:56 UTC 2023 , Edited by admin on Sat Dec 16 17:16:56 UTC 2023

PRIMARY

DRUG BANK

DB00346

Created by admin on Sat Dec 16 17:16:56 UTC 2023 , Edited by admin on Sat Dec 16 17:16:56 UTC 2023

PRIMARY

RXCUI

17300

Created by admin on Sat Dec 16 17:16:56 UTC 2023 , Edited by admin on Sat Dec 16 17:16:56 UTC 2023

PRIMARY

RxNorm

INN

5357

Created by admin on Sat Dec 16 17:16:56 UTC 2023 , Edited by admin on Sat Dec 16 17:16:56 UTC 2023

PRIMARY

FDA UNII

90347YTW5F

Created by admin on Sat Dec 16 17:16:56 UTC 2023 , Edited by admin on Sat Dec 16 17:16:56 UTC 2023

PRIMARY

EVMPD

SUB05319MIG

Created by admin on Sat Dec 16 17:16:56 UTC 2023 , Edited by admin on Sat Dec 16 17:16:56 UTC 2023

PRIMARY

MERCK INDEX

m1501

Created by admin on Sat Dec 16 17:16:56 UTC 2023 , Edited by admin on Sat Dec 16 17:16:56 UTC 2023

PRIMARY

Merck Index

DAILYMED

90347YTW5F

Created by admin on Sat Dec 16 17:16:56 UTC 2023 , Edited by admin on Sat Dec 16 17:16:56 UTC 2023

PRIMARY

WIKIPEDIA

ALFUZOSIN

Created by admin on Sat Dec 16 17:16:56 UTC 2023 , Edited by admin on Sat Dec 16 17:16:56 UTC 2023

PRIMARY

PUBCHEM

2092

Created by admin on Sat Dec 16 17:16:56 UTC 2023 , Edited by admin on Sat Dec 16 17:16:56 UTC 2023

PRIMARY

IUPHAR

7109

Created by admin on Sat Dec 16 17:16:56 UTC 2023 , Edited by admin on Sat Dec 16 17:16:56 UTC 2023

PRIMARY

CAS

81403-80-7

Created by admin on Sat Dec 16 17:16:56 UTC 2023 , Edited by admin on Sat Dec 16 17:16:56 UTC 2023

PRIMARY

EPA CompTox

DTXSID6048549

Created by admin on Sat Dec 16 17:16:56 UTC 2023 , Edited by admin on Sat Dec 16 17:16:56 UTC 2023

PRIMARY

SMS_ID

100000087894

Created by admin on Sat Dec 16 17:16:56 UTC 2023 , Edited by admin on Sat Dec 16 17:16:56 UTC 2023

PRIMARY

HSDB

7290

Created by admin on Sat Dec 16 17:16:56 UTC 2023 , Edited by admin on Sat Dec 16 17:16:56 UTC 2023

PRIMARY

DRUG CENTRAL

115

Created by admin on Sat Dec 16 17:16:56 UTC 2023 , Edited by admin on Sat Dec 16 17:16:56 UTC 2023

PRIMARY

NCI_THESAURUS

C61627

Created by admin on Sat Dec 16 17:16:56 UTC 2023 , Edited by admin on Sat Dec 16 17:16:56 UTC 2023

PRIMARY

ChEMBL

CHEMBL709

Created by admin on Sat Dec 16 17:16:56 UTC 2023 , Edited by admin on Sat Dec 16 17:16:56 UTC 2023

PRIMARY

CHEBI

51141

Created by admin on Sat Dec 16 17:16:56 UTC 2023 , Edited by admin on Sat Dec 16 17:16:56 UTC 2023

PRIMARY

MESH

C047638

Created by admin on Sat Dec 16 17:16:56 UTC 2023 , Edited by admin on Sat Dec 16 17:16:56 UTC 2023

PRIMARY

Related Record Type Details


					GAT158X947

ALFUZOSIN, (S)-

ENANTIOMER -> RACEMATE


					H9XPE51RF2

ALFUZOSIN, (R)-

ENANTIOMER -> RACEMATE


					3T7136LE8K

ALPHA-1A ADRENERGIC RECEPTOR

TARGET -> INHIBITOR


					Q7A4S7HOP4

ALPHA-1B ADRENERGIC RECEPTOR

TARGET -> AGONIST


					75046A1XTN

ALFUZOSIN HYDROCHLORIDE

SALT/SOLVATE -> PARENT


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE

Interaction Type:

MAJOR


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					P5O3A2DHB2

ALPHA-1D ADRENERGIC RECEPTOR

TARGET -> INHIBITOR


					90347YTW5F

ALFUZOSIN

EXCRETED UNCHANGED

Interaction Type:

AMOUNT EXCRETED

Qualification:

URINE

Amount:


					Q7A4S7HOP4

ALPHA-1B ADRENERGIC RECEPTOR

TARGET -> INHIBITOR

Related Record Type Details


					J6OW6Z5KAD

N-(3-((4-AMINO-6,7-DIMETHOXY-QUINAZOLIN-2-YL)AMINO)PROPYL)TETRAHYDROFURAN-2-CARBOXAMIDE

METABOLITE INACTIVE -> PARENT

Comments:

in vitro


					18FS87G8N6

ALFUZOSIN LACTONE

METABOLITE INACTIVE -> PARENT

Qualification:

URINE

Amount:


					R8W7HP2RIJ

N-(3-((4-AMINO-6-HYDROXY-7-METHOXY-QUINAZOLIN-2-YL)-METHYL-AMINO)PROPYL)TETRAHYDROFURAN-2-CARBOXAMIDE

METABOLITE INACTIVE -> PARENT

Qualification:

FECAL

Amount:


					LHE12Y00R8

ALFUZOSIN HYDROXY ACID

METABOLITE INACTIVE -> PARENT

Qualification:

URINE

Amount:


					LHE12Y00R8

ALFUZOSIN HYDROXY ACID

METABOLITE INACTIVE -> PARENT

Qualification:

FECAL

Amount:


					15C8G1FF78

6,7-DIMETHOXY-N2-METHYL-2,4-QUINAZOLINEDIAMINE

METABOLITE INACTIVE -> PARENT


					X8C5VTG33W

2,4-DIAMINO-6,7-DIMETHOXYQUINAZOLINE

METABOLITE INACTIVE -> PARENT

Qualification:

URINE

Amount:


					R8W7HP2RIJ

N-(3-((4-AMINO-6-HYDROXY-7-METHOXY-QUINAZOLIN-2-YL)-METHYL-AMINO)PROPYL)TETRAHYDROFURAN-2-CARBOXAMIDE

METABOLITE INACTIVE -> PARENT

Qualification:

URINE

Amount:


					TC9X82IR3X

N-(3-((4-AMINO-7-HYDROXY-6-METHOXY-QUINAZOLIN-2-YL)-METHYL-AMINO)PROPYL)TETRAHYDROFURAN-2-CARBOXAMIDE

METABOLITE INACTIVE -> PARENT

Qualification:

FECAL

Amount:


					TC9X82IR3X

N-(3-((4-AMINO-7-HYDROXY-6-METHOXY-QUINAZOLIN-2-YL)-METHYL-AMINO)PROPYL)TETRAHYDROFURAN-2-CARBOXAMIDE

METABOLITE INACTIVE -> PARENT

Qualification:

URINE

Amount:

Related Record Type Details


					90347YTW5F

ALFUZOSIN

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC

Tmax	PHARMACOKINETIC

Volume of Distribution	PHARMACOKINETIC