PROMETHAZINE

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H20N2S
Molecular Weight	284.419
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of PROMETHAZINE

Structure Search

SMILES

CC(CN1C2=C(SC3=C1C=CC=C3)C=CC=C2)N(C)C

InChI

InChIKey=PWWVAXIEGOYWEE-UHFFFAOYSA-N

InChI=1S/C17H20N2S/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C17H20N2S
Molecular Weight	284.419
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:28:22 UTC 2023` Edited by `admin` on `Fri Dec 15 15:28:22 UTC 2023`
Record UNII	FF28EJQ494
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PROMETHAZINE

Official Name

English

promethazine [INN]

Common Name

English

FARGAN

Brand Name

English

N-(2'-DIMETHYLAMINO-2'-METHYL)ETHYLPHENOTHIAZINE

Common Name

English

PROMETHAZINE [VANDF]

Common Name

English

PROMETHAZINE [HSDB]

Common Name

English

10-(2-DIMETHYLAMINOPROPYL)PHENOTHIAZINE

Systematic Name

English

PROMETHAZINE [JAN]

Common Name

English

DIMAPP

Brand Name

English

N,N,.ALPHA.-TRIMETHYL-10H-PHENOTHIAZINE-10-ETHANAMINE

Systematic Name

English

10-(2-DIMETHYLAMINO-2-METHYLETHYL)PHENOTHIAZINE

Systematic Name

English

RP-3277

Code

English

DIPHERGAN

Brand Name

English

PROTHAZIN

Brand Name

English

10H-PHENOTHIAZINE-10-ETHANAMINE, N,N,.ALPHA.-TRIMETHYL-

Systematic Name

English

PROMETAZIN

Brand Name

English

PROCIT

Brand Name

English

PROMETHAZINE [MI]

Common Name

English

10H-PHENOTHIAZINE-10-ETHANAMINE, N,N,.ALPHA.-TRIMETHYL-, (±)-

Systematic Name

English

PROMETHAZINE [MART.]

Common Name

English

PROAZAMINE

Common Name

English

PHENOTHIAZINE, 10-(2-(DIMETHYLAMINO)PROPYL)-

Systematic Name

English

Promethazine [WHO-DD]

Common Name

English

NSC-30321

Code

English

PROTAZINE

Brand Name

English

(±)-10-(2-(DIMETHYLAMINO)PROPYL)PHENOTHIAZINE

Systematic Name

English

VALLERGINE

Brand Name

English

Classification Tree Code System Code

WHO-VATC

QR06AD52

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

WHO-ATC

V03AB05

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

WHO-ATC

R06AD52

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

NCI_THESAURUS

C740

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

NDF-RT

N0000007544

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

NDF-RT

N0000175746

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

NDF-RT

N0000007544

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

LIVERTOX

NBK548427

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

WHO-VATC

QD04AA10

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

NDF-RT

N0000007544

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

WHO-ATC

D04AA10

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

WHO-VATC

QR06AD02

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

WHO-ATC

R06AD02

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

WHO-VATC

QV03AB05

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

Code System Code Type Description

CAS

73745-50-3

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

SUPERSEDED

DRUG BANK

DB01069

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

PRIMARY

WIKIPEDIA

PROMETHAZINE

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

PRIMARY

MERCK INDEX

m9171

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

PRIMARY

Merck Index

ECHA (EC/EINECS)

200-489-2

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

PRIMARY

EPA CompTox

DTXSID7023518

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

PRIMARY

EVMPD

SUB10088MIG

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

PRIMARY

NCI_THESAURUS

C779

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

PRIMARY

CAS

60-87-7

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

PRIMARY

CHEBI

8461

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

PRIMARY

DRUG CENTRAL

2286

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

PRIMARY

NSC

30321

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

PRIMARY

HSDB

3173

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

PRIMARY

SMS_ID

100000081146

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

PRIMARY

INN

516

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

PRIMARY

IUPHAR

7282

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

PRIMARY

ChEMBL

CHEMBL643

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

PRIMARY

DAILYMED

FF28EJQ494

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

PRIMARY

MESH

D011398

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

PRIMARY

RXCUI

8745

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

PRIMARY

RxNorm

PUBCHEM

4927

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

PRIMARY

FDA UNII

FF28EJQ494

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

PRIMARY

LACTMED

Promethazine

Created by admin on Fri Dec 15 15:28:22 UTC 2023 , Edited by admin on Fri Dec 15 15:28:22 UTC 2023

PRIMARY

Related Record Type Details


					LR0F81F33L

ALDEHYDE OXIDASE

METABOLIC ENZYME -> INHIBITOR

Qualification:

IC50

Amount:


					27EM8884DE

PROMETHAZINE HIBENZATE

SALT/SOLVATE -> PARENT

Amount:


					S5PUP23U26

PROMETHAZINE TEOCLATE

SALT/SOLVATE -> PARENT

Amount:


					YS4J699MRE

PROMETHAZINE, (R)-

ENANTIOMER -> RACEMATE

Amount:


					28XBT591QG

HISTAMINE H1 RECEPTOR

TARGET -> INHIBITOR

Amount:


					9764B60L6Y

PROMETHAZINE MALEATE

SALT/SOLVATE -> PARENT

Amount:


					8E4LAA4357

CYTOCHROME P450 2D6

METABOLIC ENZYME -> INHIBITOR

Qualification:

Ki

Amount:


					75S19OE56R

PROMETHAZINE METHYLENEDISALICYLATE

SALT/SOLVATE -> PARENT

Amount:


					QC4KTE9PLG

Promethazine Pamoate

SALT/SOLVATE -> PARENT

Amount:


					R61ZEH7I1I

PROMETHAZINE HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:

Related Record Type Details


					7ZM2Q27WD2

MONODESMETHYL PROMETHAZINE SULFOXIDE

METABOLITE -> PARENT

Amount:

Related Record Type Details


					FF28EJQ494

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
LIVER/PLASMA RATIO	PHARMACOKINETIC
Volume of Distribution	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC				Elimination PHARMACOKINETIC Elimination PHARMACOKINETIC Elimination PHARMACOKINETIC Elimination PHARMACOKINETIC

LIVER CONCENTRATION	PHARMACOKINETIC